|Rajeev Rohatgi MD
Associate Professor of Medicine
Visiting Associate Professor of Medicine, Stony Brook University School of Medicine
Chief, Renal Section, Northport VAMC
Associate Professor of Medicine, Icahn School of Medicine at Mount Sinai
Essential hypertension affects millions of adults in the U.S. and contributes to end organ damage including congestive heart failure, stroke and kidney failure. The mechanisms underlying essential hypertension are unknown; however, dysregulated sodium absorption by the kidney is a critical contributor to the development of hypertension. The goals of our research program are to identify the mechanisms underlying renal sodium avidity in hypertension and develop novel therapeutics that targets these mechanisms.
The collecting duct is the final renal site of sodium regulation/transport and is the focus our investigations. We and others have shown that tubular flow regulates cation transport in the collecting duct and this response is, in part, related to changes in tubular flow rate. Flow can directly influence channel activity, but also induces multiple autocrine/paracrine factors that modulate transepithelial sodium transport. We hypothesize that altering the plasma membrane’s biophysical properties, specifically, the lipid composition, affects flow mediated paracrine signaling that enhances Na transport and contributes to hypertension.