Lab Publications

Bartko JC, Li Y, Sun G, Halterman MW. Phosphorylation within the bipartite NLS alters the localization and toxicity of the ER stress response factor DDIT3/CHOP. Cell Signal. 2020 Oct;74:109713. doi: 10.1016/j.cellsig.2020.109713. Epub 2020 Jul 14. PubMed PMID: 32673756; PubMed Central PMCID: PMC7484389.

Simpkins AN, Busl KM, Amorim E, Barnett-Tapia C, Cervenka MC, Dhakar MB, Etherton MR, Fung C, Griggs R, Holloway RG, Kelly AG, Khan IR, Lizarraga KJ, Madagan HG, Onweni CL, Mestre H, Rabinstein AA, Rubinos C, Dionisio-Santos DA, Youn TS, Merck LH, Maciel CB. Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care. Neurocrit Care. 2020 Sep 21;. doi: 10.1007/s12028-020-01085-0. [Epub ahead of print] PubMed PMID: 32959201.

Mai N, Prifti V, Lim K, O'Reilly MA, Kim M, Halterman MW. Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia. J Stroke Cerebrovasc Dis. 2020 Sep;29(9):104942. doi: 10.1016/j.jstrokecerebrovasdis.2020.104942. Epub 2020 May 14. PubMed PMID: 32807413; PubMed Central PMCID: PMC7438610.

Mai N, Prifti V, Kim M, Halterman MW. Characterization of neutrophil-neuronal co-cultures to investigate mechanisms of post-ischemic immune-mediated neurotoxicity. J Neurosci Methods. 2020 Jul 15;341:108782. doi: 10.1016/j.jneumeth.2020.108782. Epub 2020 May 20. PubMed PMID: 32445795; PubMed Central PMCID: PMC7372713.

Trzeciak A, Lerman YV, Kim TH, Kim MR, Mai N, Halterman MW, Kim M. Long-Term Microgliosis Driven by Acute Systemic Inflammation. J Immunol. 2019 Dec 1;203(11):2979-2989. doi: 10.4049/jimmunol.1900317. Epub 2019 Oct 16. PubMed PMID: 31619539; PubMed Central PMCID: PMC6868345.

Sims MH, Hodges Shaw M, Gilbertson S, Storch J, Halterman MW. Legal and ethical issues surrounding the use of crowdsourcing among healthcare providers. Health Informatics J. 2019 Dec;25(4):1618-1630. doi: 10.1177/1460458218796599. Epub 2018 Sep 7. PubMed PMID: 30192688.

Mai N, Miller-Rhodes K, Knowlden S, Halterman MW. The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection. J Cereb Blood Flow Metab. 2019 Jun;39(6):939-958. doi: 10.1177/0271678X19835552. Epub 2019 Mar 13. Review. PubMed PMID: 30866740; PubMed Central PMCID: PMC6547189.

Mai N, Miller-Rhodes K, Prifti V, Kim M, O'Reilly MA, Halterman MW. Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia. J Am Heart Assoc. 2019 May 7;8(9):e011801. doi: 10.1161/JAHA.118.011801. PubMed PMID: 31030600; PubMed Central PMCID: PMC6512081.

Buczynski BW, Mai N, Yee M, Allen JL, Prifti L, Cory-Slechta DA, Halterman MW, O'Reilly MA. Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia. Front Med (Lausanne). 2018;5:334. doi: 10.3389/fmed.2018.00334. eCollection 2018. PubMed PMID: 30619855; PubMed Central PMCID: PMC6295554.

Mills BN, Albert GP, Halterman MW. Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer Microenviron. 2017 Dec;10(1-3):57-68. doi: 10.1007/s12307-017-0197-6. Epub 2017 Aug 18. PubMed PMID: 28822081; PubMed Central PMCID: PMC5750201.

Mai N, Prifti L, Rininger A, Bazarian H, Halterman MW. Endotoxemia induces lung-brain coupling and multi-organ injury following cerebral ischemia-reperfusion. Exp Neurol. 2017 Nov;297:82-91. doi: 10.1016/j.expneurol.2017.07.016. Epub 2017 Jul 28. PubMed PMID: 28757259; PubMed Central PMCID: PMC5612886.

Pröschel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, Halterman MW, Paciorkowski AR. Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology. Eur J Hum Genet. 2017 Feb;25(2):216-221. doi: 10.1038/ejhg.2016.145. Epub 2016 Dec 14. PubMed PMID: 27966542; PubMed Central PMCID: PMC5255945.

Sims MH, Fagnano M, Halterman JS, Halterman MW. Provider impressions of the use of a mobile crowdsourcing app in medical practice. Health Informatics J. 2016 Jun;22(2):221-31. doi: 10.1177/1460458214545896. Epub 2014 Aug 28. PubMed PMID: 25167866.

Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR. De novo mutations in SIK1 cause a spectrum of developmental epilepsies. Am J Hum Genet. 2015 Apr 2;96(4):682-90. doi: 10.1016/j.ajhg.2015.02.013. PubMed PMID: 25839329; PubMed Central PMCID: PMC4385182.

Sims MH, Bigham J, Kautz H, Halterman MW. Crowdsourcing medical expertise in near real time. J Hosp Med. 2014 Jul;9(7):451-6. doi: 10.1002/jhm.2204. Epub 2014 Apr 17. PubMed PMID: 24740747.

Matthews TA, Abel A, Demme C, Sherman T, Pan PW, Halterman MW, Parkkila S, Nehrke K. Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia. Brain Res. 2014 Jan 16;1543:28-37. doi: 10.1016/j.brainres.2013.11.018. Epub 2013 Nov 23. PubMed PMID: 24275196; PubMed Central PMCID: PMC3888505.

Rininger A, Dejesus C, Totten A, Wayland A, Halterman MW. MKP-1 antagonizes C/EBPβ activity and lowers the apoptotic threshold after ischemic injury. Cell Death Differ. 2012 Oct;19(10):1634-43. doi: 10.1038/cdd.2012.41. Epub 2012 Apr 20. PubMed PMID: 22522596; PubMed Central PMCID: PMC3438493.

Rininger A, Wayland A, Prifti V, Halterman MW. Assessment of CA1 injury after global ischemia using supervised 2D analyses of nuclear pyknosis. J Neurosci Methods. 2012 Jun 15;207(2):181-8. doi: 10.1016/j.jneumeth.2012.04.010. Epub 2012 Apr 21. PubMed PMID: 22542732; PubMed Central PMCID: PMC4224947.

Qazi A, Halterman MW, Mi Z, Zhang T, Schor NF. Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress. Oxid Med Cell Longev. 2011;2011:391659. doi: 10.1155/2011/391659. Epub 2011 Sep 5. PubMed PMID: 21904642; PubMed Central PMCID: PMC3166776.

Segel GB, Halterman MW, Lichtman MA. The paradox of the neutrophil's role in tissue injury. J Leukoc Biol. 2011 Mar;89(3):359-72. doi: 10.1189/jlb.0910538. Epub 2010 Nov 19. Review. PubMed PMID: 21097697; PubMed Central PMCID: PMC6608002.

Halterman MW. An improved method for the study of apoptosis-related genes using the tet-on system. J Biomol Screen. 2011 Mar;16(3):332-7. doi: 10.1177/1087057110397355. Epub 2011 Feb 18. PubMed PMID: 21335597.

Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. J Biol Chem. 2010 Jul 9;285(28):21329-40. doi: 10.1074/jbc.M109.095299. Epub 2010 May 6. PubMed PMID: 20448044; PubMed Central PMCID: PMC2898390.

Halterman MW, Giuliano R, Dejesus C, Schor NF. In-tube transfection improves the efficiency of gene transfer in primary neuronal cultures. J Neurosci Methods. 2009 Mar 15;177(2):348-54. doi: 10.1016/j.jneumeth.2008.10.023. Epub 2008 Oct 30. PubMed PMID: 19014969; PubMed Central PMCID: PMC2652259.

Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci. 2008 Jun;38(2):125-37. doi: 10.1016/j.mcn.2008.01.014. Epub 2008 Feb 13. PubMed PMID: 18439838; PubMed Central PMCID: PMC2652244.

Halterman MW, Vates GE, Riggs G. Teaching NeuroImage: tremor in aqueductal stenosis and response to endoscopic third ventriculostomy. Neurology. 2007 May 8;68(19):E29-31. doi: 10.1212/01.wnl.0000260971.91440.48. PubMed PMID: 17485639.

Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. J Gene Med. 2006 Nov;8(11):1320-8. doi: 10.1002/jgm.972. PubMed PMID: 16989006; NIHMSID:NIHMS261478.

Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004 Feb;149(1):1-10. doi: 10.1016/S0165-4608(03)00234-6. PubMed PMID: 15104276; NIHMSID:NIHMS261477.

Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep;236(3):337-42; discussion 342-3. doi: 10.1097/00000658-200209000-00010. PubMed PMID: 12192320; PubMed Central PMCID: PMC1422587.

Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Mol Ther. 2002 Jun;5(6):723-30. doi: 10.1006/mthe.2002.0609. PubMed PMID: 12027556; NIHMSID:NIHMS261475.

Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Mol Ther. 2001 Sep;4(3):250-6. doi: 10.1006/mthe.2001.0448. PubMed PMID: 11545616; NIHMSID:NIHMS261473.

Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol Med. 2001 Aug;7(8):561-8. PubMed PMID: 11591892; PubMed Central PMCID: PMC1950059.

Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 2001 Jul 15;98(2):287-95. doi: 10.1182/blood.v98.2.287. PubMed PMID: 11435295; NIHMSID:NIHMS261472.

Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Ther. 2001 Jan;8(2):111-20. doi: 10.1038/sj.gt.3301340. PubMed PMID: 11313780; NIHMSID:NIHMS261471.

Bennett JJ, Kooby DA, Delman K, McAuliffe P, Halterman MW, Federoff H, Fong Y. Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer. J Mol Med (Berl). 2000;78(3):166-74. doi: 10.1007/s001090000092. PubMed PMID: 10868479.

Van de Water TR, Staecker H, Halterman MW, Federoff HJ. Gene therapy in the inner ear. Mechanisms and clinical implications. Ann N Y Acad Sci. 1999 Nov 28;884:345-60. doi: 10.1111/j.1749-6632.1999.tb08653.x. Review. PubMed PMID: 10842605; NIHMSID:NIHMS261470.

D'Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity. Mol Med. 1999 Sep;5(9):606-16. PubMed PMID: 10551902; PubMed Central PMCID: PMC2230459.

Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol. 1999 Sep;159(1):65-72. doi: 10.1006/exnr.1999.7160. Review. PubMed PMID: 10486175; NIHMSID:NIHMS261468.

Halterman MW, Miller CC, Federoff HJ. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci. 1999 Aug 15;19(16):6818-24. PubMed PMID: 10436039; PubMed Central PMCID: PMC6782875.

Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). FASEB J. 1999 Aug;13(11):1325-34. doi: 10.1096/fasebj.13.11.1325. PubMed PMID: 10428757; NIHMSID:NIHMS261488.

Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Hum Gene Ther. 1999 Jul 1;10(10):1599-606. doi: 10.1089/10430349950017608. PubMed PMID: 10428205; NIHMSID:NIHMS261467.

White SM, Renda M, Nam NY, Klimatcheva E, Zhu Y, Fisk J, Halterman M, Rimel BJ, Federoff H, Pandya S, Rosenblatt JD, Planelles V. Lentivirus vectors using human and simian immunodeficiency virus elements. J Virol. 1999 Apr;73(4):2832-40. doi: 10.1128/JVI.73.4.2832-2840.1999. PubMed PMID: 10074131; PubMed Central PMCID: PMC104041.

Brooks AI, Halterman MW, Federoff HJ. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 1999 Feb 5;10(2):337-44. doi: 10.1097/00001756-199902050-00024. PubMed PMID: 10203332; NIHMSID:NIHMS261487.

Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 1999 Jan 15;93(2):643-54. PubMed PMID: 9885227; NIHMSID:NIHMS261465.

D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y. In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors. Cancer Immunol Immunother. 1999 Jan;47(5):265-71. doi: 10.1007/s002620050530. PubMed PMID: 10022470; NIHMSID:NIHMS261466.

Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y. Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. Am J Surg. 1998 Nov;176(5):404-8. doi: 10.1016/s0002-9610(98)00231-1. PubMed PMID: 9874422; NIHMSID:NIHMS261485.

Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF 3rd. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Am J Pathol. 1998 Jun;152(6):1521-9. PubMed PMID: 9626056; PubMed Central PMCID: PMC1858445.

Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ. Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. J Neurosci Methods. 1998 Apr 30;80(2):137-47. doi: 10.1016/s0165-0270(97)00207-0. PubMed PMID: 9667386; NIHMSID:NIHMS261484.

Federoff HJ, Halterman MW, Brooks AI. Use of the herpes amplicon system as a vehicle for somatic gene transfer. Adv Drug Deliv Rev. 1997 Aug 11;27(1):29-39. doi: 10.1016/s0169-409x(97)00020-3. PubMed PMID: 10837549; NIHMSID:NIHMS261490.