1R01CA2203667-01 (coPI’s: T. Rosenquist, R. Turesky)
Stony Brook University, University of Minnesota
DNA Adductomics of the Urinary System
This research program is designed to establish targeted, data-dependent (DDA) and data-independent acquisition (DIA) methods to screen for DNA adducts in human tissues, focusing on genetoxic chemicals found in the environment, diet, and herbal medicines, and on mutagens produced endogenously. This study characterizes DNA adducts found in renal and urothelial tissues and in exfoliated urinary cells of cancer patients, using DDA and DIA MS scanning methods to correlate DNA adduct signatures with mutational signatures.
06/20/2017 – 06/30/2022
ES0188092 (PI: R. Turesky)
University of Minnesota, Stony Brook University
New Biomonitoring Methodologies to Measure DNA Adducts in Human Tissue
DNA adducts formed in the urinary bladder by exposure to hazardous chemicals in the environment, medicines, tobacco smoke, diet, or endogenously produced electrophiles will be screened by ion trap mass spectrometry. We will establish a robust assay employing exfoliated urinary cells as a noninvasive biospecimen to screen for DNA adducts. These biomonitoring approaches may help us to identify the chemicals that damage DNA and contribute to the etiology of bladder cancer.
08/01/2016 – 07/31/2021
R21 ES028539-01 (PI: Rosenquist)
Stony Brook University
DNA Adduct Genomics
The goal of this project is to immune-purify and sequence genomic DNA fragments containing DNA adducts.
07/01/2017 – 06/31/2021
R56ES029514 (PI: V. Sidorenko)
Stony Brook University
The Molecular and Cellular Mechanisms Underlying the Carcinogenicity and of Aristolochic Acid: Hallmarks of a Global Environmental Disease
The goal of this research is to identify molecular mechanisms responsible for toxicities, biotransformation and transport of aristolochic acids. These studies will enable detection of individuals sensitive to aristolochic acid-induced disease.
09/1/2019 - 08/31/2021
Marsha & Henry Laufer Foundation (PI: Grollman)
Stony Brook University
Toxicogenomics of Aristolochic Acid Nephropathy and Associated Cancers
Unrestricted funding for studies of populations worldwide in which the signature mutation for aristolochic acid has been established as a proximate cause of renal cell, hepatocellular and other human cancers.
09/01/2012 – 08/31/2023
Zickler Family Foundation (PI: Grollman)
Stony Brook University
Funding to support a fifth Zickler Translational Scholar and a clinical trial for a novel drug treatment for Covid 19
06/01/2021—06/01/2024
Acknowledgement: The Director gratefully acknowledges funding from Dr. Marsha Laufer to support the Grollman-Gombo Scholarship in Public Health.
