|The Center for Understanding Biology using Imaging Technology (CUBIT) uses advanced imaging modalities to investigate neuropsychiatric disorders and their treatment. The group makes important discoveries related to psychiatric disorders as well as developing new radioligands and techniques for quantification and analysis.|
|Pathophysiology and Treatment of Bipolar Disorder||Characterization of a New Metabotropic Glutamate Receptor Subtype 5 PET Ligand||Biosignature of Antidepressant Response|
CUBIT is conducting a multi-site study of the underlying causes of bipolar disorder using advanced brain scanning techniques.
CUBIT is characterizing a novel PET radioligand, an antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), in humans.
The CUBIT participates in a multi-site research project seeking biosignatures for the personalized treatment of depression.
|Biomarkers of Major Depressive Disorder||Reference region approaches in PET||CUBIT Datasets|
CUBIT combines several imaging modalities, using advanced machine learning and statistical classification techniques to develop a deeper understanding of the pathophysiology of depression.
CUBIT develops reference region approaches for positron emission tomography (PET) brain studies in order to obtain full quantification without arterial input function sampling, an invasive and costly procedure.
|Download CUBIT datasets|
Director of CUBIT
Christine DeLorenzo, PhD, earned her doctoral degree in Biomedical Engineering at Yale University. After completing a Postdoctoral research fellowship in the Division of Molecular Imaging and Neuropathology at Columbia University, Dr. DeLorenzo was appointed Assistant Professor of Clinical Neurobiology at Columbia University. In 2012 she was appointed Assistant Professor of Psychiatry and Assistant Professor of Biomedical Engineering at Stony Brook University. In 2016 she was promoted to Associate Professor.
Stephanie Brown, PhD
Kenneth Gadow, PhD
Doreen Olvet, PhD
Francesca Zanderigo, PhD
Post-Doctoral Research Fellow
Zafer Işcan, PhD
Nehal Vadhan, PhD
Sunia Choudhury, MA
Kalynn Gruenfelder, BA
Ryan Patterson, BA
George Wright, MS
Programmer/AnalystStephen Huysman, BS
John Gardus, MEng
Ananth Narayanan, PhD
M. Çağdaş Eker, PhD