1. Department of Psychiatry
  2. Center for Understanding Biology using Imaging Technology (CUBIT)
  3. CUBIT Datasets

CUBIT Datasets

Raphe Nuclei, PRF, & OLFS ROIs

Raphe Nuclei Raphe Nuclei

Schematic of individual raphe nuclei, adapted from Son et al. (2012). DRN: dorsal raphe nucleus; MRN: median raphe nucleus; RPo: raphe pontis; RMg: raphe magnus; ROb: raphe obscurus; RPa: raphe pallidus. Caudal linear nucleus is not shown

Source: Pillai et al. 2018

Delineation of individual raphe nuclei from a [11 C]WAY100635 image.

(a) High-resolution template brain (Holmes et al., 1998) in Montreal Neurological Institute space.

(b) Voxel [11 C]WAY100635 average BPF image over 52 HV overlaid on MRI with ROIs labeled. DRN: dorsal raphe nucleus, MRN: median raphe nucleus, RMg: raphe magnus

Source: Pillai et al. 2018
Non-raphe regions 

PRF & OLFS

Molecular VOIs labeled in sagittal (a), coronal (b), and oblique views (c) as a 3D image projection of an averaged [11 C]-WAY100635 image. OLFS: olfactory sulcus; PRF: piriform cortex. (d) Molecular VOIs show greater binding potential than nearby structurally defined regions. ACN: anterior cingulate; HIP: hippocampus.

Source: Pillai et al. 2018

  

Relevant Studies

  • Rajapillai L.I. Pillai, Chuan Huang, Andrew LaBella, Mengru Zhang, Jie Yang, Madhukar Trivedi, Myrna Weissman, Patrick McGrath, Maurizio Fava, Benji Kurian, Crystal Cooper, Melvin McInnis, Maria A. Oquendo, Diego A. Pizzagalli, Ramin V. Parsey, Christine DeLorenzo
    Examining raphe-amygdala structural connectivity as a biological predictor of SSRI response, Journal of Affective Disorders, Volume 256, 2019, Pages 8-16, ISSN 0165-0327
    https://doi.org/10.1016/j.jad.2019.05.055
  • Pillai, R. L. I., Zhang, M., Yang, J., Boldrini, M., Mann, J. J., Oquendo, M. A., … DeLorenzo, C. (2018). Will imaging individual raphe nuclei in males with major depressive disorder enhance diagnostic sensitivity and specificity? Depression and Anxiety, 35(5), 411–420. https://doi.org/10.1002/da.22721
  • Pillai, R. L., Zhang, M., Yang, J., Mann, J. J., Oquendo, M. A., Parsey, R. V., & DeLorenzo, C. (2019). Molecular connectivity disruptions in males with major depressive disorder. Journal of Cerebral Blood Flow & Metabolism, 39(8), 1623–1634. https://doi.org/10.1177/0271678x18764053