SBMS Trainee: Xiaofei Li
Graduate Advisor: Yi-Xian Qin
Clinical Advisor: Prof. Marie Gelato
Graduate Program: Biomedical Engineering
Email: xiaofei.li@stonybrook.edu
I am currently a PhD candidate in Biomedical Engineering Department in Stony Brook University. My research area is mainly related with the application of noninvasive ultrasound for diagnosis and therapy in musculoskeletal disorders, such as osteoarthritis (OA). OA is a major health concern in adults and elderly people in United State. The treatment for OA remains serious challenges. Existing therapies, such as injection of drug in synovial space, joint disuse, moderate exercise, joint replacement surgery and arthroscopic surgical intervention, could only alleviate joint pain and mitigate deformity, but could not slow cartilage degradation and OA progression. Ultrasound is a form of mechanical wave, and has obvious advantages in achievement and maintenance of bone and cartilage health. Because ultrasound is noninvasive, nonradiative, and less expensive, and can be transmitted into biological tissue as mechanical pressure wave, and acoustic energy is regarded as an anabolic stimulator for tissue healing. Therefore, I will use low intensity pulse ultrasound to mitigate cartilage degeneration and subchondral bone sclerosis in knee osteoarthritis in murine model, and will evaluate the ultrasound treatment on cartilage and subchondral bone for patients with knee osteoarthritis. The final goal of this project is to take our noninvasive and less expensive therapeutic ultrasound device to clinical treatment.
