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Qingping Yao, MD, PhD Professor, Department of Medicine Chief, Division of Rheumatology, Allergy and Immunology Stony Brook University Clinical Phone: (631) 444-0580 Schedule an Appointment |
Dr. Yao graduated and earned his MD from Inner Mongolia Medical College, China in 1984. He trained in Internal Medicine and Rheumatology and obtained his Ph.D at Peking Union Medical College (PUMC) in 1993 and then served as attending rheumatologist and Associate Professor of Medicine in PUMC Hospital, one of the most prestigious medical institutions in China.
Dr. Yao came to America as a visiting scholar in the Division of Rheumatology at Columbia University in 1997. He then served as a research associate and performed research on gene therapy for arthritis in Dr. Paul Robbins' laboratory at the University of Pittsburgh for five years. He retrained in American hospitals, including residency training in Capital Health System, New Jersey and rheumatology fellowship training at University of California, Los Angeles (UCLA) from 2006 to 2008.
Dr. Yao joined the Cleveland Clinic in Ohio and served as a senior rheumatologist in the top-ranked Department of Rheumatic and Immunologic Disease from 2008 to 2015, where he was inaugural Director of the Clinic for Adult Autoinflammatory Diseases. At the Cleveland Clinic, he identified the disease, Yao syndrome (OMIM617321), formerly designated as NOD2-associated autoinflammatory disease.
Dr. Yao joined the Department of Medicine, Stony Brook University in August 2015. He is Professor, Department of Medicine and serves as Chief of the Division of Rheumatology, Allergy and Immunology. He has continued providing specialized care for patients with autoinflammatory diseases/periodic fever syndromes, as well as pursuing clinical and translational study of autoinflammatory diseases. Dr. Yao’s subspecialty interests also include systemic lupus erythematosus, Sjὅgren's syndrome and paraneoplastic rheumatic diseases.
Selected Publications
Niewold T, Aksentijevich I, Gorevic P, Gibson G, Yao Q. Genetically transitional disease: conceptual understanding and applicability to rheumatic disease. Nat Rev Rheumatol. 2024, Feb 28. doi: 10.1038/s41584-024-01086-9. Online ahead of print.
Yun M, Navetta-Modrov B, Nomani H, Xin B, Yang J, Aroniadis O, Gorevic PD, Yao Q. Genetic variations in NLRP3 and NLRP12 genes in adult-onset patients with autoinflammatory diseases: a comparative study. Front Immunol 2024 Jan 26;14:1321370. doi: 10.3389/fimmu.2023.1321370. eCollection 2023.
Nomani H, Deng Z, Navetta-Modrov B, Yang J, Yun M, Aroniadis O, Aksentijevich I, Gorevic P, Yao Q. Implications of combined NOD2 and other gene mutations in autoinflammatory diseases. Front Immunol. 2023 Oct 19;14:1265404. doi: 10.3389/fimmu.2023.1265404. eCollection 2023.
Williamson KA, Yun M, Koster MJ, Arment C, Patnaik A, Chang TW, Bledsoe AC, Sae-Tia S, Shah AS, Samuels J, Davis Iii JM, Yao Q. Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease. Rheumatology (Oxford). 2023 Jul 19: kead372. doi: 10.1093/rheumatology/kead372. Online ahead of print.
Yao Q, Gorevic P, Shen B, Gibson G. Genetically transitional disease: a new concept in genomic medicine. Trends Genet. 2023 Feb;39(2):98-108
Yao Syndrome by Yao Q: Pathophysiology, Diagnosis, and Management. Book: Autoinflammatory Syndromes edited by Petros Efthimiou, Springer, 2019.
Autoinflammatory diseases by Shen M, Wu D and Yao Q. Book: Absolute Rheumatology edited by Petros Efthimiou, Springer, 2020.
Autoinflammatory diseases by Navetta-Modrov B, Kontzias A and Yao Q. Book: Rheumatology for Primary Care Providers edited by Yusaf Ali, Springer, 2021.
Rivera EG, Patnaik A, Salvemini J, Jain S, Lee K, Lozeau D, Yao Q.
SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitination. Clin Immunol. 2022 May;238:109027. doi: 10.1016/j.clim.2022.109027. Epub 2022 May 2.
Yao, Qingping. "Systemic autoinflammatory disease and genetic testing" Rheumatology and Immunology Research, vol. 2, no. 4, 2021, pp. 209-211. https://doi.org/10.2478/rir-2021-0028
Wu, Di, Shen, Min and Yao, Qingping. "Cutaneous manifestations of autoinflammatory diseases" Rheumatology and Immunology Research, vol. 2, no. 4, 2021, pp. 217-225. https://doi.org/10.2478/rir-2021-0030
Navetta-Modrov, Brianne and Yao, Qingping. "Macroglobulinemia and autoinflammatory disease" Rheumatology and Immunology Research, vol. 2, no. 4, 2021, pp. 227-232. https://doi.org/10.2478/rir-2021-0031
Yao, Qingping, Shen, Min and Gorevic, Peter. "NOD2 versus MEFV: Differential diagnosis of Yao syndrome and familial Mediterranean fever" Rheumatology and Immunology Research, vol. 2, no. 4, 2021, pp. 233-239. https://doi.org/10.2478/rir-2021-0032
Yao Q, Apostolos Kontzias. Expansion of phenotypic and genotypic spectrum of YAO syndrome: a case series. J Clin Rheumatol Dec 24, 2020
Yao Q. Research letter: Effectiveness of canakinumab for the treatment of Yao syndrome. J Am Acad Dermatol. 2019 Sep 18. pii: S0190-9622(19)32757-4. doi: 10.1016/j.jaad.2019.09.020
Yao Q, Li E, Shen B. Autoinflammatory disease with focus on NOD2-associated disease in the era of genomic medicine. Autoimmunity. 2019 May 13:1-9. doi: 10.1080/08916934.2019.1613382
McDonald C, Shen M, Johnson EE, Kabi A, Yao Q. Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome. Autoimmunity. 2018;51(2):53-61
Li H, Abramova I, Chesoni S, Yao Q. Molecular genetic analysis for periodic fever syndromes: a supplemental role for the diagnosis of adult-onset Still's disease. Clin Rheumatol. 2018 Jun 17. doi: 10.1007/s10067-018-4178-z. [Epub ahead of print]
Hua Y, Shen M, McDonald C, Yao Q. Autophagy dysfunction in autoinflammatory diseases. J Autoimmun. 2018;88:11-20.
Yao Q, Shen B. A Systematic Analysis of Treatment and Outcomes of NOD2-Associated Autoinflammatory Disease. Am J Med. 2016 Oct 28. pii: S0002-9343(16)31063-4. doi: 10.1016/j.amjmed.2016.09.028. [Epub ahead of print
Yao Q, Lacbawan F, Li J. Adult autoinflammatory disease frequency and our diagnostic experience in an adult autoinflammatory clinic. Semin Arthritis Rheum. 2016; 45(5):633-7
Yao Q, Furst DE. Autoinflammatory diseases: an update of clinical and genetic aspects.
Rheumatology (Oxford). 2008; 47(7):946-51.
Yao Q, Shen M, McDonald C, Lacbawan F, Moran R, Shen B. NOD2-associated autoinflammatory disease: a large cohort study. Rheumatology (Oxford). 2015; 54(10):1904-12
Yao Q. Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases. Semin Arthritis Rheum. 2013; 43(1):125-30.
Yao Q, Su LC, Tomecki KJ, Zhou L, Jayakar B, Shen B. Dermatitis as a characteristic phenotype of a new autoinflammatory disease associated with NOD2 mutations.
J Am Acad Dermatol. 2013; 68(4):624-31.
Yao Q, Shen M, Fernandez J. NOD2-associated autoinflammatory disease and immune deficiency. J Allergy Clin Immunol Pract. 2016; 4(4):780-2.
Estephan M, Yao Q, Springer J. Case of NOD2-Associated Autoinflammatory Disease Successfully Treated With Sulfasalazine. J Clin Rheumatol. 2017; 23(1):58-59. doi: 10.1097/RHU.0000000000000468.
Shen M, Tang L, Shi X, Zeng X, Yao Q. NLRP12 autoinflammatory disease: a Chinese case series and literature review. Clin Rheumatol. 2016 Sep 16. [Epub ahead of print]
Yao Q, Zhou L, Cusumano P, Bose N, Piliang M, Jayakar B, Su LC, Shen B.
A new category of autoinflammatory disease associated with NOD2 gene mutations.
Arthritis Res Ther. 2011; 13(5):R148.
Lenert A, Yao Q. Macrophage activation syndrome complicating adult onset Still's disease: A single center case series and comparison with literature. Semin Arthritis Rheum. 2016; 45(6):711-6
Yao Q, Myles J, Shen B, McDonald C. NOD2-associated autoinflammatory disease: an exploratory study of its pathogenesis. Rheumatology (Oxford). 2014; 53(5):958-60.
Yao Q, Ruggieri P, Lowder C. Ocular myositis occurring with NOD2-associated autoinflammatory disease. J Rheumatol. 2013; 40(10):1768-9.
Yao Q, Schils J. Distal lower extremity swelling as a prominent phenotype of NOD2-associated autoinflammatory disease. Rheumatology (Oxford). 2013; 52(11):2095-7.
Yao Q, Piliang M, Nicolacakis K, Arrossi A.Granulomatous pneumonitis associated with adult-onset Blau-like syndrome. Am J Respir Crit Care Med. 2012; 186(5):465-6.
Shen M, Moran R, Tomecki KJ, Yao Q. Granulomatous disease associated with NOD2 sequence variants and familial camptodactyly: An intermediate form of NOD2-associated diseases? Semin Arthritis Rheum. 2015; 45(3):357-60.
Yao Q, Englund KA, Hayden SP, Tomecki KJ.Tumor necrosis factor receptor associated periodic fever syndrome with photographic evidence of various skin disease and unusual phenotypes: case report and literature review. Semin Arthritis Rheum. 2012; 41(4):611-7.
Yao Q, Yerian L, Shen B. Missense mutation V20A in the tumor necrosis factor receptor superfamily 1A (TNFRSF1A) gene is associated with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) presenting with periodic gastrointestinal symptoms. Inflamm Bowel Dis. 2011; 17(6):1445-6.
https://www.omim.org/entry/617321
https://ghr.nlm.nih.gov/condition/yao-syndrome
https://www.the-rheumatologist.org/?s=yao+syndrome
