Virology/Extracellular Vesicles:
Long-Term Low-Dose Delta-9-Tetrahydrocannbinol (THC) Administration to Simian Immunodeficiency Virus (SIV) Infected Rhesus Macaques Stimulates the Release of Bioactive Blood Extracellular Vesicles (EVs) that Induce Divergent Structural Adaptations and Signaling Cues. Lyu Y, Kopcho S, Mohan M, Okeoma CM. Cells. 2020 Oct 6;9(10):2243 doi: 10.3390/cells9102243. PMID: 33036231.
Electrostatic Surface Properties of Blood and Semen Extracellular Vesicles: Implications of Sialylation and HIV-Induced Changes on EV Internalization. Kaddour H, Panzner TD, Welch JL, Shouman N, Mohan M, Stapleton JT, Okeoma CM. Viruses. 2020 Oct 1;12(10):1117. doi: 10.3390/v12101117. PMID: 33019624.
Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies. Mohan M, Okeoma CM, Sestak K. Int J Mol Sci. 2020 Jul 29;21(15):5407. doi: 10.3390/ijms21155407. PMID: 32751379.
Development of Novel High-Resolution Size-Guided Turbidimetry-Enabled Particle Purification Liquid Chromatography (PPLC): Extracellular Vesicles and Membraneless Condensates in Focus. Kaddour H, Lyu Y, Shouman N, Mohan M, Okeoma CM. Int J Mol Sci. 2020 Jul 28;21(15)5361. doi: 10.3390/ijms21155361. PMID: 32731547.
Glycerol Monolaurate, an Analogue to a Factor Secreted by Lactobacillus, Is Virucidal against Enveloped Viruses, Including HIV-1. Welch JL, Xiang J, Okeoma CM, Schlievert PM, Stapleton JT. mBio. 2020 May 5;11(3); e00686-20. doi: 10.1128/mBio.00686-20. PMID: 32371599.
Semen Extracellular Vesicles From HIV-1-Infected Individuals Inhibit HIV-1 Replication In Vitro, and Extracellular Vesicles Carry Antiretroviral Drugs In Vivo. Welch JL, Kaddour H, Winchester L, Fletcher CV, Stapleton JT, Okeoma CM. J Acquir Immune Defic Syndr. 2020 Jan 1; 83(1): 90-98. doi: 10.1097/QAI.0000000000002233 PMID: 31809364
Proteomics profiling of autologous blood and semen exosomes from HIV-infected and uninfected individuals reveals compositional and functional variabilities. Kaddour H, Lyu Y, Welch JL, Paromov V, Mandape SN, Sakhare SS, Pandhare J, Stapleton JT, Pratap S, Dash C, Okeoma CM. Mol Cell Proteomics. 2019 Nov 1. pii: mcp.RA119.001594. doi: 10.1074/mcp.RA119.001594. PMID: 31676584
Semen exosomes inhibit HIV infection and HIV-induced proinflammatory cytokine production independently of the activation state of primary lymphocytes. Welch JL, Kaufman TM, Stapleton JT, Okeoma CM. FEBS Lett. 2019 Oct 30. doi: 10.1002/1873-3468.13653. PMID: 31665815
Human Immunodeficiency Virus (HIV) Infection and Use of Illicit Substances Promote Secretion of Semen Exosomes that Enhance Monocyte Adhesion and Induce Actin Reorganization and Chemotactic Migration. Lyu Y, Kaddour H, Kopcho S, Panzner TD, Shouman N, Kim EY, Martinson J, McKay H, Martinez-Maza O, Margolick JB, Stapleton JT, Okeoma CM. Cells. 2019 Sep 3;8(9). pii: E1027. doi: 10.3390/cells8091027
Semen exosomes promote transcriptional silencing of HIV-1 by disrupting NF-kB/Sp1/Tat circuitry. Welch JL, Kaddour H, Schlievert PM, Stapleton JT, Okeoma CM. J Virol. 2018 Aug 15. pii: JVI.00731-18. doi: 10.1128/JVI.00731-18. [Epub ahead of print]. PMID: 30111566
Effect of prolonged freezing of semen on exosome recovery and biologic activity. Welch JL, Madison MN, Margolick JB, Galvin S, Gupta P, Martínez-Maza O, Dash C, Okeoma CM. Sci Rep. 2017 Mar 24;7:45034. doi: 10.1038/srep45034. PMID: 28338013
Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex. Madison MN, Jones PH, Okeoma CM. Virology. 2015 Aug;482:189-201. doi: 10.1016/j.virol.2015.03.040. Epub 2015 Apr 13. PMID: 25880110
Human semen contains exosomes with potent anti-HIV-1 activity. Madison MN, Roller RJ, Okeoma CM. Retrovirology. 2014 Nov 19;11:102. doi: 10.1186/s12977-014-0102-z. PMID: 25407601
Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection. Mahauad-Fernandez WD, Jones PH, Okeoma CM. J Gen Virol. 2014 Nov;95(Pt 11):2450-61. doi: 10.1099/vir.0.068643-0. Epub 2014 Jul 22. PMID: 25053563
BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). Jones PH, Maric M, Madison MN, Maury W, Roller RJ, Okeoma CM. Virology. 2013 Mar 30;438(1):37-49. doi: 10.1016/j.virol.2013.01.010. Epub 2013 Feb 12. PMID: 23411007
IFN-α and lipopolysaccharide upregulate APOBEC3 mRNA through different signaling pathways. Mehta HV, Jones PH, Weiss JP, Okeoma CM. J Immunol. 2012 Oct 15;189(8):4088-103. doi: 10.4049/jimmunol.1200777. Epub 2012 Sep 12. PMID: 22972924
A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice. Jones PH, Mehta HV, Okeoma CM. Retrovirology. 2012 Jun 12;9:50. doi: 10.1186/1742-4690-9-50. PMID: 22691411
Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo. Jones PH, Mehta HV, Maric M, Roller RJ, Okeoma CM. Retrovirology. 2012 Jan 27;9:10. doi: 10.1186/1742-4690-9-10. PMID: 22284121
Cancer:
Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) as a Novel Anti-Cancer Drug Lead. Lyu Y, Kopcho S, Alvarez FA, Okeoma BC, Okeoma CM. Cancers 2020 Aug 28, 12(9), 2448
Development and Characterization of the Shortest Anti-Adhesion Peptide Analogue of B49Mod1. Lyu Y, Mahauad-Fernandez WD, Okeoma CM. Molecules. 2020 Mar 6;25(5):1188. doi: 10.3390/molecules25051188. PMID: 32155736
BST-2 promotes survival in circulation and pulmonary metastatic seeding of breast cancer cells. Mahauad-Fernandez WD, Naushad W, Panzner TD, Bashir A, Lal G, Okeoma CM. Sci Rep. 2018 Dec 4;8(1):17608. doi: 10.1038/s41598-018-35710-y. PMID: 30514852
B49, a BST-2-based peptide, inhibits adhesion and growth of breast cancer cells. Mahauad-Fernandez WD, Okeoma CM. Sci Rep. 2018 Mar 9;8(1):4305. doi: 10.1038/s41598-018-22364-z. PMID: 29523843
Structural determinant of BST-2-mediated regulation of breast cancer cell motility: a role for cytoplasmic tail tyrosine residues. Naushad W, Mahauad-Fernandez WD, Okeoma CM. Oncotarget. 2017 Nov 29;8(66):110221-110233. doi: 10.18632/oncotarget.22753. eCollection 2017 Dec 15. PMID: 29299143
Cysteine-linked dimerization of BST-2 confers anoikis resistance to breast cancer cells by negating proapoptotic activities to promote tumor cell survival and growth. Mahauad-Fernandez WD, Okeoma CM. Cell Death Dis. 2017 Mar 16;8(3):e2687. doi: 10.1038/cddis.2017.68. PMID: 28300825
Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells. Mahauad-Fernandez WD, Borcherding NC, Zhang W, Okeoma CM. PLoS One. 2015 Apr 10;10(4):e0123931. doi: 10.1371/journal.pone.0123931. eCollection 2015. PMID: 25860442
Bone marrow stromal antigen 2 expressed in cancer cells promotes mammary tumor growth and metastasis. Mahauad-Fernandez WD, DeMali KA, Olivier AK, Okeoma CM. Breast Cancer Res. 2014 Dec 13;16(6):493. doi: 10.1186/s13058-014-0493-8. PMID: 25499888
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated BST-2/tetherin regulation. Jones PH, Okeoma CM. Cell Signal. 2013 Dec;25(12):2752-61. doi: 10.1016/j.cellsig.2013.08.042. Epub 2013 Sep 13. PMID: 24036213
BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer. Jones PH, Mahauad-Fernandez WD, Madison MN, Okeoma CM. Virology. 2013 Sep;444(1-2):124-39. doi: 10.1016/j.virol.2013.05.042. Epub 2013 Jun 25. PMID: 23806386
Review Articles:
Vehicles of intercellular communication: exosomes and HIV-1. Welch JL, Stapleton JT, Okeoma CM. J Gen Virol. 2019 Mar;100(3):350-366. doi: 10.1099/jgv.0.001193. Epub 2019 Jan 31. PMID: 30702421
BST-2: at the crossroads of viral pathogenesis and oncogenesis Mahauad-Fernandez WD, Okeoma CM. Future Virology. 2016 Feb 01. 11(2):127-140 https://doi.org/10.2217/fvl.15.113
The role of BST-2/Tetherin in host protection and disease manifestation. Mahauad-Fernandez WD, Okeoma CM. Immun Inflamm Dis. 2015 Dec 7;4(1):4-23. doi: 10.1002/iid3.92. eCollection 2016 Mar. Review. PMID: 27042298
Exosomes: Implications in HIV-1 Pathogenesis. Madison MN, Okeoma CM. Viruses. 2015 Jul 20;7(7):4093-118. doi: 10.3390/v7072810. Review. PMID: 26205405
Methods Articles:
Isolation of Exosomes from Semen for in vitro Uptake and HIV-1 Infection Assays. Madison MN, Welch JL, Okeoma CM. Bio Protoc. 2017 Apr 5;7(7). pii: e2216. doi: 10.21769/BioProtoc.2216. PMID: 28660234
Journal Covers:
Elsevier – Virology Volume 438, Issue 1, 30 March 2013, Pages 1-50 https://www.sciencedirect.com/journal/virology/vol/438/issue/1
Book Chapters:
Mahauad-Fernandez W.D. and Okeoma CM. Restriction Factors and Chikungunya virus. In Chikungunya virus: Advances in Biology, Pathogenesis, and Treatment, Okeoma C.M. Ed., Springer Science and Business Media: N.Y., USA. 2016. Pages 185-197 https://www.springer.com/us/book/9783319429564
Books Edited:
Chikungunya virus: Advances in Biology, Pathogenesis, and Treatment: Okeoma CM. Ed.; Springer Science and Business Media: N.Y., USA 2016. https://www.springer.com/us/book/9783319429564
Editorials:
Viruses and Extracellular Vesicles: Special Issue, 2020, with Thirteen Articles by Chioma M. Okeoma. Okeoma CM. Viruses. 2020 Nov 6;12(11):1265. doi: 10.3390/v12111265. PMID: 33172073
