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B.S., 2009, Portland State University, Portland, Oregon Ph.D. 2017, Stony Brook University Advisor: Patrick Hearing |
| Research Interests | Our lab studies Adenovirus (Ad), a human DNA tumor virus which serves as an excellent model to study the molecular mechanisms of viral infection. My thesis work focuses on the small viral protein, E4-ORF3, which is critical for counteracting several innate antiviral responses elicited during Ad infection. Understanding exactly how E4-ORF3 functions to promote virus infection will not only provide clues into Ad pathogenesis, but may also prove useful in our understanding of cellular responses to viral infection. |
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Honors and Awards |
Sigma Xi Travel Award, Stony Brook University, 2016. Outstanding poster Award, Annual Retreat, Department of Molecular Genetics and Microbiology, 2016 Distinguished Service Award, Department of Molecular Genetics and Microbiology, Stony Brook University, 2015 ASM 115th Student Travel Award, American Society for Microbiology, 2015 Molecular and Cell Biology of Infectious Diseases Training Program, Department of Molecular Genetics and Microbiology, Stony Brook University, 2014-present Cancer Biochemistry and Cell Biology Training Program, Department of Molecular Genetics and Microbiology, Stony Brook University, 2013-2014 Excellence in Teaching Award, Department of Molecular Genetics and Microbiology, Stony Brook University, 2013 |
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Publications |
Bridges, R.G., Sohn, S.-Y., Wright, J., Leppard, K.N., Hearing, P. (2016). The adenovirus E4-ORF3 protein stimulates SUMOylation of general transcription factor TFII-I to direct proteasomal degradation. mBio 7(1):e02184-15. PMID: 26814176 Sohn, S.-Y., Bridges, R.G., and Hearing, P. (2014). Proteomic analysis of ubiquitin-Like posttranslational modifications induced by the adenovirus E4-ORF3 protein. Journal of Virology 89(3):1744-55. 2015. PMID: 25410875 Liu, Y., Bridges, R., Wortham, A., and Kulesz-Martin, M. (2012). NF-κB repression by PIAS3 mediated RelA SUMOylation. PLoS One 7(5):e37636. PMID: 22649547 |
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Presentations |
Bridges, R.G., Sohn, S.-Y., Wright, J., Leppard, K.N., and Hearing, P. The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of the General Transcription Factor TFII-I to Direct Proteasomal Degradation. DNA Tumor Virus Meeting 2016. July 18-23, Montreal, Canada. Bridges, R., Sohn, S.-Y., and Hearing, P. (2015). Identification of Ubiquitin-like Post-translational Modifications Induced by the Adenovirus E4-orf3 Protein. 115th General Meeting of the American Society for Microbiology. May 30 - June 2, New Orleans, LA. |
