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Michael P Motley

B.S., 2012, Biological Sciences, Cornell University, Ithaca, NY
Advisor: Bettina Fries
Email: Michael.Motley@stonybrook.edu

Research Interests

Pathogen-host interactions are a constant arms race, and for years humans held the advantage against infectious organisms thanks to drugs that could support our natural defenses. With the recent proliferation of antibiotic-resistant bacteria however, the tide of battle is turning, and new means to combat infection must be found. Monoclonal antibodies against conserved traits are one such weapon. In the Fries Lab, we are designing antibodies against the polysaccharide capsule of carbapenem-resistant Klebsiella pneumoniae strains, and examining their ability to assist the host immune system in clearing infection. We hope that these antibodies will provide protection against those elderly and hospitalized patients these bacteria have become a mortal threat to. In addition to my research, I also enjoy SCUBA Diving, running, playing kickball, and karaoke.

Honors and Awards

Medical Scientist Training Program fellowship, 2012

Motley, M.P. (2019). National Institutes of Health F30 Pre-doctoral Fellowship, “Studying the Role of the Anti-capsular Antibodies in Mediating Pathogenesis of Carbapenem-resistant Klebsiella pneumoniae”.

Publications

Diago-Navarro, E., Motley, M.P., Ruiz-Perez, G., Yu, W., Austin, J., Seco, B.M.S., Xiao, G., Chikhalya, A., Seeberger, P.H., and Fries, B.C. (2018). Novel, broadly reactive anticapsular antibodies against carbapenem-resistant Klebsiella pneumoniae protect from infection. MBio 9(2): e00091.

Motley, M.P., and Fries, B.C. (2017). A new take on an old remedy: generating antibodies against multidrug-resistant Gram-negative bacteria in a postantibiotic world. mSpere 2(4): e00397.

Motley, M.P.§, Madsen, D.H.§, Jürgensen, H.J., Spencer, D.E., Szabo, R., Holmbeck, K., Flick, M.J., Lawrence, D.A., Castellino, F.J., Weigert, R., and Bugge, T.H. (2016). A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood 127(9):1085-96. PMCID: 4778161. §Equal contribution

Hagarman, J.A., Motley, M.P., Kristjansdottir, K., and Soloway, P.D. (2013). Coordinate Regulation of DNA Methylation and H3K27me3 in Mouse Embryonic Stem Cells. PLoS One 8(1) e53880. PMCID: 3543269.

Presentations

Motley, M.P., Diago-Navarro, E., Yu, W., Ruiz-Perez, G., Chikhalya, A.Y., and Fries, B.C. Characterizating Monoclonal Antibodies Generated Against the Capsular Polysaccharide of ST258 Carbapenem-Resistant Klebsiella pneumoniae. June 1-5, 2017. ASM Microbe, New Orleans, LA.