Publications

Iron

Leftin A, Ben-Chetrit N, Joyce JA, Koutcher JA. Imaging Endogenous Macrophage iron Deposits Reveals a Metabolic Biomarker of Polarized Tumor Macrophage Infiltration and Response to CSF1R Breast Cancer Immunotherapy. Sci. Rep. 2019, 9, 857. Pubmed PMID: 30696910.

Leftin A, Koutcher JA.   (2018) Quantification of Nanoparticle Enhancement in Polarized Breast Tumor Macrophage Deposits by Spatial Analysis of MRI and Histological Iron Contrast using Computer Vision. Contrast Med. Mol. Imaging, 2018, Article 3526438. Pubmed PMID 30510494.

Leftin A, Ben-Chetrit N, Klemm, F, Joyce JA, Koutcher JA. Iron imaging reveals tumor and metastasis macrophage hemosiderin deposits in breast cancer. PLOS ONE, 2017 Sep 12;12(9):e0184765. Pubmed PMID 28898277.

Leftin A, Zhao H, Turkekul M, de Stanchina E, Manova K, Koutcher JA. Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer. Sci Rep. 2017 Sep 14;7(1):11632. Pubmed PMID: 28912459.

Lipids

Leftin A, Job C, Beyer K, Brown MF. Solid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-Synuclein. J Mol Biol. 2013 Aug 23;425(16):2973-87. PubMed PMID: 23583776.
 

Leftin A, Molugu TR, Job C, Beyer K, Brown MF. Area per lipid and cholesterol interactions in membranes from separated local-field (13)C NMR spectroscopy. Biophys J. 2014 Nov 18;107(10):2274-86. PubMed PMID: 25418296; PubMed Central PMCID: PMC4241443.

Leftin A, Brown MF. An NMR database for simulations of membrane dynamics. Biochim Biophys Acta. 2011 Mar;1808(3):818-39. PubMed PMID: 21134351.

Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K. The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophys J. 2010 Oct 6;99(7):2116-24. PubMed PMID: 20923645; PubMed Central PMCID: PMC3042581.

Magnetic Resonance

Leftin A, Degani H, Frydman L. In vivo magnetic resonance of hyperpolarized [(13)C1]pyruvate: metabolic dynamics in stimulated muscle. Am J. Physiol. Endocrinol. Metab. 2013 Nov 1;305(9):E1165-71. PubMed PMID: 24022866.

Leftin A, Roussel T, Frydman L. Hyperpolarized functional magnetic resonance of murine skeletal muscle enabled by multiple tracer-paradigm synchronizations. PLoS One. 2014 9(4):e96399. PubMed PMID: 24769864; PubMed Central PMCID: PMC4000219.

Leftin A, Rosenberg JT, Solomon E, Calixto Bejarano F, Grant SC, Frydman L. Ultrafast in vivo diffusion imaging of stroke at 21.1 T by spatiotemporal encoding. Magn Reson Med. 2015 Apr;73(4):1483-9. PubMed PMID: 24845125.

Seginer A, Schmidt R, Leftin A, Solomon E, Frydman L. Referenceless reconstruction of spatiotemporally encoded imaging data: principles and applications to real-time MRI. Magn Reson Med. 2014 Dec;72(6):1687-95. PubMed PMID: 24420445.

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