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B.S., 2013, Macaulay Honors College at the City College of New York |
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Research Interests |
Undergraduate research was focused on studying the mechanisms underlying hematopoietic cancer and inflammation using Drosophila molecular genetics. Current work revolves around the role host sphingolipids in fungal infections. More specifically, the goal of the current research is to define a role for sphingomyelin and cholesterol, known constituents of lipid rafts, in the phagocytic response to Cryptococcus neoformans. |
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Honors and Awards |
Travel Award, Gordon Research Conference in Glycolipid and Sphingolipid Biology, 2018 Teresa Haire Award, Department of Molecular Genetics and Microbiology, 2016 Award for Excellence in In Vivo Research by the Molecular Mycology of Pathogenic Fungi (MOMY) at Marine Biological Laboratories (MBL), 2016 Appointment to T32AI007539 Institutional Training Grant NIAID, 2015 Travel Award from Medical Mycological Society of the Americas (MMSA), 2014 Outstanding Student Poster from American Society for Microbiology (ASM) General Meeting, 2014 |
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Publications |
Bryan, A.M., You, J.K., Li, G., Kim, J., Singh, A., Morstein, J., Trauner, D., Pereira de Sa, N., Normile, T.G., Farnoud, A.M, London, E., and Del Poeta, M. (2021). Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages. Journal of Biological Chemistry 297(6): 101411. Normile, T.G., Bryan, A.M., and Del Poeta, M. (2020). Animal models of Cryptococcus neoformans in identifying immune parameters associated with primary infection and reactivation of latent infection. Frontiers in Immunology 11: 581750. Bryan, A.M., You, J.K., McQuiston, T., Lazzarini, C., Qiu, Z., Sheridan, B.S., Nuesslein-Hildesheim, B., and Del Poeta, M. (2020). FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages. Journal of Clinical Investigation. doi: 10.1172/JCI136068. Bryan, A.M., and Del Poeta, M. Lipid Metabolism in Model Fungi: The Achilles Heel of Fungal Pathogens. in Reference Module in Life Sciences (Elsevier, 2018). doi:10.1016/B978-0-12-809633- Bryan, A.M., and Del Poeta, M. (2018). Sphingosine-1-phosphate receptors and innate immunity. Cell Microbiology 20(5): e12836. Bryan, A.M., and Del Poeta, M. (2016). Secretory aspartyl proteinases induce neutrophil chemotaxis in vivo. Virulence 30: 1-3. PMID: 27362660 Bryan, A.M., Del Poeta M., and Luberto, C. (2015). Sphingolipids as regulators of the phagocytic response to fungal infections. Mediators of Inflammation. Article ID 640540. PMID:26688618. de Oliveira, H.C., Joffe, L.S., Simon, K.S., Castelli, R.F., Reis, F.C.G., Bryan, A.M., Borges, B.S., Soares Medeiros, L.C., Bocca, A.L., Del Poeta, M., and Rodrigues, M.L. (2020). Fenbendazole controls in vitro growth, virulence potential, and animal infection in the Cryptococcus model. Antimicrobial Agents and Chemotherapy 64(6): e00286-20. Mor, V., Rella, A., Farnoud, A.M., Singh, A., Munshi, M., Bryan, A.M...and Del Poeta, M. (2015). Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids. mBio. 6(3):e00647. PMID:26106079. Farnoud, A.M., Bryan, A.M., Kechichian, T., Luberto, C., and Del Poeta, M. (2015). The granuloma response controlling cryptococcosis in mice depends on the SK1-S1P pathway. Infection and Immunity. 83(7):2705-13. PMID:25895971. Bryan, A. M., Farnoud, A.M., Mor, V., and Del Poeta, M. (2014). Macrophage cholesterol depletion and its effect on the phagocytosis of Cryptococcus neoformans, Journal of Visualized Experiments, PMID: 25549203. |
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Select Presentations |
McEvoy, K., Normile, T., Byran, A., and Del Poeta, M. (2019). Sphingosine Kinase 1 Regulated Clearance of Cryptococcus neoformans sgl1 Mutant. 2019 Symposium on Harnessing Immunity to Combat Infection and Disease, April 29, Stony Brook University, Stony Brook, NY. Normile, T.G., Colombo, A.C., Rella, A., Bryan, A., and Del Poeta, M. (2019). Unraveling the Immunological basis of Protection Elicited by Cryptococcus neoformans sgl1. 2019 Symposium on Harnessing Immunity to Combat Infection and Disease, April 29, Stony Brook University, Stony Brook, NY. Bryan, A. M., and Del Poeta, M. (2018). Role of sphingosine-1-phosphate signaling in the granulomatous response to Cryptococcus neoformans, Gordon Research Conference in Glycolipid and Sphingolipid Biology 11-16 February 16, 2018 Galveston, TX United States. (Poster presentation) Bryan, A. M., Farnoud, A.M., and Del Poeta, M. 2014. Cholesterol depletion from alveolar macrophages affects their infectivity with Cryptococcus neoformans, 114th General Meeting of The American Society for Microbiology (ASM), Boston, MA (Oral presentation) |
