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B.A., Biology, Hofstra University M.S., Biotechnology, New York University Ph.D., 2021 Advisor: Brian S. Sheridan |
| Research Interests | The immune system has a natural capacity to detect and eliminate infected and/or abnormal cells, however diseases often find ways to evade detection whether is it through dysfunctional T-cells, an altered stromal microenvironment, or other mechanisms. My current research interests are immunotherapies and methods to re-engineer the immune system for treatment. |
| Presentations |
Chu, T.H., Khairallah, C., Cho, R., Zhang, Y., Lin, X., Bliska, J.B., and Sheridan, B.S. (2019). Yersinia pseudotuberculosis Outer Proteins Inhibit Adaptive gamma delta T Cell Functions. Institute of Chemical Biology & Drug Discovery 13th Annual Symposium, Oct 10, Stony Brook University, Stony Brook, NY. Chu, T.H., Khairallah, C., Zhang, Y., Lin, X., Bliska, J.B., and Sheridan, B.S. (2019). Yersinia pseudotuberculosis Outer Proteins Inhibit Adaptive gd T Cell Functions. 2019 Symposium on Harnessing Immunity to Combat Infection and Disease, April 29, Stony Brook University, Stony Brook, NY. Shieh, J., Chu, T.H., Liu, Y., Kim, J.M., Ruiz de Sabando, A., Sheridan, B.S., Bialkowska, A.B., and Yang, V.W. (2020). Disruption of Intestinal Epithelium with the Deletion of Kruppel-like Factor 5 (KLF5) Resembles the Inflammatory Response in Human Inflammatory Bowel Disease. Annual Digestive Disease Week (DDW) Meeting 2020, May 2-5, Chicago, IL. |
| Publications |
Qiu, Z., Khairallah, C., Chu, T.H., Imperato, J.N., Lei, X., Romanov, G., Atakilit, A., Puddington, L., and Sheridan, B.S. (2023). Retinoic acid signaling during priming licenses intestinal CD103+ CD8+ TRM cell differentiation. Journal of Experimental Medicine 220(5): e2021923.Chu, T.H., Qiu, Z., and Sheridan, B.S. (2022). The use of foodborne infection to evaluate bacterial pathogenesis and host response. Methods in Cell Biology 168: 299-314. Normile, T.G., Chu, T.H., Sheridan, B.S., and Del Poeta, M. (2022). Vaccine protection by Cryptococcus neoformans ∆sgl1 is mediated by γδ T cells via TLR2 signaling. Mucosal Immunology 15(6): 1416-1430. Lin, X., Gaudino, S.J., Jang, K.K., Bahadur, T., Singh, A., Banerjee, A., Beaupre, M., Chu, T., Wong, H.T., Kim, C.-K., Kempen, C., Axelrad, J., Huang, H, Khalid, S., Shah, Vyom, Eskiocak, O., Parks, O.B., Berisha, A., McAleer, J.P., Good, M., Hoshino, M., Blumberg, R., Bialkowska, A.B., Gaffen, S.L., Kolls, J.K., Yang, V.W., Beyaz, S., Cadwell, K., and Kumar, P. (2022). IL-17RA-signaling in Lgr5+ intestinal epithelial cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity 55(2): 237-253. Shieh, J., Chu, T.H., Liu, Y., Kim, J., Ruiz de Sabando, A., Kobayashi, S., Zee, S.Y., Sheridan, B.S., Bialkowska, A.B., and Yang, V.W. (2022). KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model. JCI Insight 7(7): e153488. Chu, T.H., Khairallah, C., Shieh, J., Cho, R, Qiu, Z., Zhang, Y., Eskiocak, O., Thanassi, D.G., Kaplan, M.H., Beyaz, S., Yang, V.W., Bliska, J.B., and Sheridan, B.S. (2021). γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans. PLos Pathogens 17(12): e1010103. Khairallah, C., Bettke, J.A., Gorbatsevych, O., Qiu, Z., Zhang, Y., Cho, K., Kim, K.S., Chu, T.H., Imperato, J.N., Hatano, S., Romanov, G., Yoshikai, Y., Puddington, L., Surh, C.D., Bliska, J.B., van der Velden, A.W.M, and Sheridan, B.S. (2021). A blend of broadly-reactive and pathogen-selected Vγ4Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells. Mucosal Immunology, doi: 10.1038/s41385-021-00447-x. Qiu, Z., Qiu, Z., Chu, T.H., and Sheridan, B.S. (2021). TGF-B: Many paths to CD103+ T cell residency. Cells 10(5): 989. Khairallah, C., Chu, T.H., and Sheridan, B.S. (2018). Tissue adaptations of memory and tissue-resident gamma delta T cells. Frontiers in Immunology 9: 2636.
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