Xun Lin

B.S., Biosciences, University of Science and Technology of China
Ph.D., Molecular Genetics and Microbiology
Advisor: Pawan Kumar

Research Interests

The immune system is able to recognize and eliminate pathogens in infection. If the immune system is exposed to foreign pathogens, it may generate long-lasting immunity, which is called immunological memory. However, it still remains something unknown in the process. My current research interest is to investigate the mechanism on immunological memory.
 

Publications

Lin, X., Gaudino, S.J., Jang, K.K., Bahadur, T., Singh, A., Banerjee, A., Beaupre, M., Chu, T., Wong, H.T., Kim, C.-K., Kempen, C., Axelrad, J., Huang, H, Khalid, S., Shah, Vyom, Eskiocak, O., Parks, O.B., Berisha, A., McAleer, J.P., Good, M., Hoshino, M., Blumberg, R., Bialkowska, A.B., Gaffen, S.L., Kolls, J.K., Yang, V.W., Beyaz, S., Cadwell, K., and Kumar, P. (2022). IL-17RA-signaling in Lgr5+ intestinal epithelial cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity 55(2): 237-253.

Lin, X., Tawch, S., Wong, H.T., Roy, S., Gaudino, S., Castillo, P., Elsegeiny, W., Wakabayashi, N., Oury, T.D., Pociask, S., Chen, Kong, McLinskey, N., Melville, P., Syritsyna, O., Coyle, P., Good, M., Awashthi, A., Kolls, J.K., and Kumar, P. (2021). Nrf2 through aryl hydrocarbon receptor regulates IL-22 response in CD4 T cells. Journal of Immunology 206(7): 1540-1548.

Gaudino, S.J., Beaupre, M., Lin, X., Joshi, P., Rathi, S., McLaughlin, P.A., Kempen, C., Mehta, N., Eskiocak, O., Yueh, B., Blumberg, R.S., van der Velden, A.W.M., Shroyer, K.R., Bialkowska, A.B., Beyaz, S., and Kumar, P. (2020). IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity. Mucosal Immunity, doi: 10.1038/s41385-020-00348-5.

Gaudino, S.J., Huang, H., Jean-Pierre, M., Beaupre, M., Lin, X., and Kumar, P. (2019). Cross-talk between antigen presenting cells and T cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis. Frontiers in Immunology, doi 10.3389/fimmu.2019.00360.

Presentations

Gaudino, S., Huang, H., Jena-Pierre, M., Beaupre, M., Lin, X., and Kumar, P. (2019). Intestinal Interleukin (IL)-22Ra1 Signaling Regulates the Reciprocal Cntrol of IL-22 and Onset of High Fat Diet-induced Metabolic Disorders. 2019 Symposium on Harnessing Immunity to Combat Infection and Disease, April 29, Stony Brook University, Stony Brook, NY.

Gaudino, S.J., Huang, H., Jean-Pierre, M., Beaupre, M., Lin, X., and Kumar, P. (2019). Intestinal Interleukin (IL)-22RA1 Signaling Regulates the Reciprocal Control of IL-22 and Onset of High Fat Diet-induced Metabolic Disorders. Immunology 2019, American Association of Immunologists, May 9-13, San Diego, CA.

Lin, X., Gaudino, S., Kolls, J., and Kumar, P. (2019). Nrf2 Selectively Regulates IL-22 and IL-17A Production in Th17 Cells. Immunology 2019, American Association of Immunologists, May 9-13, San Diego, CA