Michael P. Motley

B.S., 2012, Biological Sciences, Cornell University, Ithaca, NY
Ph.D., 2020, M.D., 2022, Stony Brook University
Advisor: Bettina Fries

Research Interests

Pathogen-host interactions are a constant arms race, and for years humans held the advantage against infectious organisms thanks to drugs that could support our natural defenses. With the recent proliferation of antibiotic-resistant bacteria however, the tide of battle is turning, and new means to combat infection must be found. Monoclonal antibodies against conserved traits are one such weapon. In the Fries Lab, we are designing antibodies against the polysaccharide capsule of carbapenem-resistant Klebsiella pneumoniae strains, and examining their ability to assist the host immune system in clearing infection. We hope that these antibodies will provide protection against those elderly and hospitalized patients these bacteria have become a mortal threat to. In addition to my research, I also enjoy SCUBA Diving, running, playing kickball, and karaoke.

Honors and Awards

Motley, M.P. (2019). National Institutes of Health F30 Pre-doctoral Fellowship, “Studying the Role of the Anti-capsular Antibodies in Mediating Pathogenesis of Carbapenem-resistant Klebsiella pneumoniae”.

Motley, M.P. (2012). Medical Scientist Training Program fellowship.


Banerjee, K., Motley, M.P., Boniche-Alfaro, C., Bhattacharya, S., Shah, R., Ardizzone, A., and Fries, B.C. (2022). Patient-derived antibody data yields development of broadly cross-protective monoclonal antibody against ST258 carbapenem-resistant Klebsiella pneumoniae. Microbial Spectrum, in press.

Banerjee, K., Motley, M.P., Diago-Navarro, E., and Fries, B.C. (2021). Serum antibody responses against carbapenem-resistant Klebsiella pneumonieae in infected patients. mSphere 6(2):e01335.

Motley, M.P., Diago-Navarro, E., Banerjee, K., Inserillo, S., and Fries, B.C. (2020). The role of IgG subclass in antibody-mediated protection against carbapenem-resistant Klebsiella pneumoniae. mBio 11(5):e02059-20.

Motley, M.P., Bennett-Guerrero, E., Fries, B.C., and Spitzer, E.D. (2020). Review of viral testing (polymerase chain reaction) and antibody/serology testing for severe acute respiratory syndrome-coronovirus-2 for the intensivist. Critical Care Explorations 2(6): e0154.

Motley, M.P., Banerjee, K., and Fries, B.C. (2019). Monoclonal antibody-based therapies for bacterial infections. Current Opinions in Infectious Diseases 32(3): 210-216.

Diago-Navarro, E., Motley, M.P., Ruiz-Perez, G., Yu, W., Austin, J., Seco, B.M.S., Xiao, G., Chikhalya, A., Seeberger, P.H., and Fries, B.C. (2018). Novel, broadly reactive anticapsular antibodies against carbapenem-resistant Klebsiella pneumoniae protect from infection. MBio 9(2): e00091.

Motley, M.P., and Fries, B.C. (2017). A new take on an old remedy: generating antibodies against multidrug-resistant Gram-negative bacteria in a postantibiotic world. mSpere 2(4): e00397.

Motley, M.P.§, Madsen, D.H.§, Jürgensen, H.J., Spencer, D.E., Szabo, R., Holmbeck, K., Flick, M.J., Lawrence, D.A., Castellino, F.J., Weigert, R., and Bugge, T.H. (2016). A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood 127(9):1085-96. PMCID: 4778161. §Equal contribution

Hagarman, J.A., Motley, M.P., Kristjansdottir, K., and Soloway, P.D. (2013). Coordinate Regulation of DNA Methylation and H3K27me3 in Mouse Embryonic Stem Cells. PLoS One 8(1) e53880. PMCID: 3543269.


Motley, M.P., Diago-Navarro, E., Yu, W., Ruiz-Perez, G., Chikhalya, A.Y., and Fries, B.C. Characterizating Monoclonal Antibodies Generated Against the Capsular Polysaccharide of ST258 Carbapenem-Resistant Klebsiella pneumoniae. June 1-5, 2017. ASM Microbe, New Orleans, LA.