Nancy C. Reich Marshall


Professor, Department of Microbiology and Immunology
President, International Cytokine & Interferon Society (ICIS)
Fellow of The American Association for the Advancement of Science (AAAS)


(631) 632-8650
(631) 632-9797


Lab Members



Cytokine Signaling

Cytokines are essential mediators that regulate multiple cellular responses including immune defense, differentiation, programmed cell death, proliferation and malignancy. They are secreted proteins and bind to cell surface receptors to stimulate diverse signal transduction pathways that control gene expression, and in turn, the biological activities of the cell. Many cytokines activate latent tyrosine kinases of the Janus family (JAKs) that phosphorylate and activate signaling molecules such as the signal transducers and activators of transcription (STATs). This flow of information is known as a JAK-STAT pathway and rapidly transduces signals from outside of the cell to the nucleus.

Our research has centered on the diverse functions of STAT factors. Cytokines activate specific STAT factors that control targeted gene expression and biological effects. Interferons confer resistance to viral infections, and the STAT1 and STAT2 factors are critical for this defense response. Inflammatory cytokines and oncogenic tyrosine kinases regulate cell survival and proliferation, and STAT3 and STAT5 factors that are linked to these responses. Our objectives are to understand the mechanisms that regulate STAT factors and the function of STAT-regulated genes.