Nancy C. Reich Marshall


Professor, Department of Microbiology and Immunology
Past President, International Cytokine & Interferon Society (ICIS)
Fellow of The American Association for the Advancement of Science (AAAS)


(631) 632-8650
(631) 632-9797


Lab Members



Cytokine Signaling, Gene Expression, Immune Defense, Cancer

Immune defense, differentiation, programmed cell death, and malignancy are all influenced by extracellular cytokines. Our research centers on the action of a subset of cytokines that stimulate Janus tyrosine kinases (JAKs) and signal transducers and activators of transcription (STATs). Activated JAK-STAT pathways rapidly transduce signals from outside the cell into the nucleus to regulate gene expression. Although the JAK-STAT cytokines use similar signal transduction pathways, their biological effects are quite diverse. For example, interferons confer resistance to viral infections, whereas interleukin-6 promotes inflammation and malignancy. We are currently exploring mouse models of viral infection and pancreatic cancer to identify molecular mechanisms that can be used to combat these diseases.