Publications

For the most current list, see this PubMed search.

Trainee co-authors are in bold.

We thank Stony Brook University, SUNY, Stony-Wold Herbert Fund, America Lung Association, Burroughs Wellcome Fund, NSF, NIGMS, and NIAID for supporting our work and trainees over the years.

• Jaisinghani, N., Previti, M.L., Andrade, J., Askenazi, M., Ueberheide, B., Seeliger, J.C. (2024) Cell wall proteomics in live Mycobacterium tuberculosis uncovers exposure of ESX substrates to the periplasm. Cell Chem Biol, PMCID: PMC1110675 (available 2025-03-21), doi: 10.1016/j.chembiol.2023.10.013
• Nisbett, L-M.*, Previti, M.L., Seeliger, J.C*. (2023) Loss of function in LprG-Rv1410c attenuates growth in biofilm formation in Mycobacterium smegmatis. Pathogens, 12, 1375. PMCID: PMC10745849 (* co-corresponding authors)

         Special Issue "Biology of Mycobacterial Pathogens", eds. D. Chatterjee, D. Crick, L. Quadri

• Hegelmeyer N.K., Parkin, L.A., Previti M.L., Andrade J., Utama R., Sejour R.J., Gardin J., Muller S., Ketchum S., Yurovsky A., Futcher B., Goodwin S., Ueberheide B., Seeliger J.C. (2023) Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria. mBio, e00841-23. PMCID: PMC10653884 
• Ahamed, M., Jaisinghani, N., Li, M., Winkeler, I., Silva, W.S., Previti, M.L., Seeliger, J.C. (2022) Optimized APEX2 peroxidase-mediated proximity labeling in fast- and slow-growing mycobacteria, Meth Enzymol 664, 267-289. PMID: 35331378
• Baskin, J., Seeliger, J.C. (2021) A look at the lives of lipids, Curr Topics Chem Biol 65:A4-A6. PMID: 34742653, doi: 10.1016/j.cbpa.2021.102094
• Jaisinghani, N., Seeliger, J.C. (2021) Recent advances in the mass spectrometric profiling of bacterial lipids, Curr Topics Chem Biol 65:145-153. PMID: 34600165, doi: 10.1016/j.cbpa.2021.08.003
• Li, M., Patel, H. V., Cognetta III, A. B., Mallick, I., Cavalier, J. F., Canaan, S., Aldridge, B. B., Cravatt, B. F., Seeliger, J. C. (2021) Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling, Cell Chem Biol, 29, 883-896. PMCID: PMC8964833 (* authors contributed equally to this work)
• Bai, L.*, Parkin, L.A.*, Zhang, H., Shum, R., Previti, M.L., Seeliger, J.C. (2020) Dimethylaminophenyl hydrazides as inhibitors of the lipid transport protein LprG in mycobacteria. ACS Infect Dis, 10, 637-648. PMCID: PMC7436943 (* authors contributed equally to this work)
• Van Vlack, E. R., Seeliger, J.C. (2018) Acid Trip: Zika Virus Goes Off-Pathway during pH-Triggered Membrane Fusion, ACS Cent Sci, doi:10.1021/acscentsci.8b00706

• Patel, H. V., Li, M., Seeliger, J.C. (2018) Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria, Curr Topics Microbiol Immunol doi: 10.1007/82_2018_125

• Ganapathy, U.S., Bai, L., Wei, L., Eckartt, K.A., Lett, C.M., Previti, M.L., Carrico, I.S., Seeliger, J.C. (2018) Compartment-Specific Labeling of Bacterial Periplasmic Proteins by Peroxidase-Mediated Biotinylation, ACS Infect Dis. 4, 918-925.
   
• Touchette, M. H., Van Vlack, E., Bai, L., Kim, J., Cognetta, A. B., Previti, M. L., Backus, K. M., Martin, D. W., Cravatt, B. F., and Seeliger, J. C. (2017) A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link Between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A, ACS Infect Dis. 5, 336-348.

• Touchette, M. H.,  Seeliger, J. C. (2017) Transport of Outer Membrane Lipids in Mycobacteria, BBA Mol Cel Biol Lipids, 1862, 1340-1354.

• Van Vlack, E. R., Topp S., Seeliger, J.C. (2017) Characterization of engineered preQ1 riboswitches for inducible gene regulation in mycobacteria, J Bacteriol 199, e00656-16.

• Seeliger, J. C. and Moody, D. B. (2016) Monstrous Mycobacterial Lipids, Cell Chem Biol. 23, 207.

• Martinot, A. J., Farrow, M. F., Bai, L., Layre, E., Cheng, T. Y., Tsai, J. H. C., Iqbal, J., Annand, J. W., Sulllivan, Z., Hussain, M. M., Sacchettini, J. C., Moody, D. B., Seeliger, J. C.*, and Rubin, E. J*. (2016) Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis, PLoS Pathog. 12, e1005351. (* co-corresponding author)

• Touchette M. H., Bommineni G. R., Delle Bovi R. J., Gadbery J. E., Nicora C. D., Shukla A. K., Kyle, J. E., Metz, T. O., Martin, D. W., Sampson, N. S., Miller, W. T., Tonge, P. J., Seeliger, J. C. (2015) Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl Beta-Diol Lipids. Biochemistry 54, 5457–5468.

• Van Vlack, E. R., Seeliger, J. C. (2015) Using riboswitches to regulate gene expression and define gene function in mycobacteria. Meth. Enzymol. 550, 251-265.

• Touchette, M. H., Holsclaw C. M., Previti, M. L., Solomon, V. C., Leary, J. A., Bertozzi, C. R., Seeliger, J. C. (2015) The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J. Bacteriol. 197, 201-210.

• Seeliger, J. C. (2012) Scientists must be taught to manage. Nature 483, 511. doi: 10.1038/483511

Prior to Stony Brook University (also under maiden name)

• Seeliger, J. C., Holsclaw, C. M., Schelle, M. W., Botyzanszki, Z., Gilmore, S. A., Tully, S. E., Niederweis, M., Cravatt, B. F., Leary, J. A., Bertozzi, C. R. (2012)  Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 287, 7990-8000.
• Seeliger, J. C., Topp, S., Sogi, K. M., Previti, M. L., Gallivan, J. P., Bertozzi, C. R. (2012) A Riboswitch-Based Inducible Gene Expression System for Mycobacteria.  PLoS One. 7, e29266.
• Topp, S., Reynoso, C. M. K., Seeliger, J. C., Goldlust, I. S., Desai, S. K., Murat, D., Shen, A., Puri, A. W., Komeili, A., Bertozzi, C. R., Scott, J. R., Gallivan, J. P.  (2010) Synthetic Riboswitches that Induce Gene Expression in Diverse Bacterial Species.  Appl. Environ. Microbiol.  76, 7881-7884.
• Chuang, J. I., Boxer, S. G., Holten, D., Kirmaier, C.  (2008) Temperature Dependence of Electron Transfer to the M-side Bacteriopheophytin in Rhodobacter capsulatus Reaction Centers.  J. Phys. Chem. B.  112, 5487-5499.
• Fafarman, A., Webb, L. J., Chuang J. I., Boxer S. G.  (2006) Site-Specific Conversion of Cysteine Thiols into Thiocyanate Creates an IR Probe for Electric Fields in Proteins.  J. Amer. Chem. Soc. 128, 13356-13357.
• Chuang, J. I., Boxer, S. G., Holten, D., Kirmaier, C.  (2006) High Yield of M-side Electron Transfer in Mutants of Rhodobacter capsulatus Reaction Centers Lacking the Initial Electron Acceptor Bacteriopheophytin.  Biochemistry 45, 3845-3851.
  • Featured in “Science & Technology: Photosynthesis Mystery Cracked,” Chem. Eng. News (2006) 84(15), 54.
• Khan, F., Chuang, J. I., Gianni, S., Fersht, A. R.  (2003)  The kinetic pathway of folding of barnase.  J. Mol. Biol. 333, 169-86
• Craig, N.C., Chuang, J. I., Nwofor, C. C., Oertel, C. M.  (2000)  Synthesis and vibrational spectroscopy of 1,1,2,2-tetrafluoroethane and its ¹³C₂- and d₂- isotopomers.  J. Phys. Chem. A 104, 10092-103.