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CUBIT: PET Research Core

The Center for Understanding Biology using Imaging Technology

CUBIT is a team of image analysts, programmers and engineers, focused on extracting the most accurate quantitative information from medical images.

CUBIT facilitates image acquisition and analysis from Magnetic Resonance Imaging sequences including:

  • structural MRI
  • functional MRI (task and task-free)
  • diffusion MRI (DTI and DSI)
  • Arterial Spin Labeling (ASL, blood flow)
  • Spectroscopy

We also aid in the acquisition and analysis of Positron Emission Tomography (PET) including:

  • Drug Occupancy Studies
  • Longitudinal Analysis
  • Test-retest (stability) Analysis

In conjunction with the Facility for Experimental Radiopharmaceutical Manufacturing (FERM) and PET Ex Vivo Radiometabolite Laboratory (PERL), we will assist with imaging studies for any discipline (e.g. neurology, cardiology, oncology, etc.) or target (e.g. brain, heart, lung, liver, etc.) in humans, baboons or rodents.

The Center is directed by Christine DeLorenzo, PhD, who holds a PhD in Biomedical Engineering and has 10+ years experience in medical imaging analysis.

The PET Research Core is directed by Professor Ramin Parsey, MD, PhD, Della Pietra Family Chair of Biomedical Imaging and Director of PET Research at Stony Brook University.


Services

  • Assistance preparing applications for internal pilot funding, government and private foundation groups
  • Assistance developing imaging protocols
  • Quality Assurance of PET and MRI images
  • HIPAA compliant storage of demographic, clinical and image data that is backed up daily
  • Raw image data files
  • Transparent image analysis pipeline with web-based interface for viewing results
  • Write-up of methodology for manuscripts
  • Full PET quantification including
    • Fitting of plasma and metabolite data
    • Time activity curve generation
    • Kinetic/Graphical modeling
  • Regional and voxel analysis on a group level

Imaging Facilities

The SCAN Center

The Social, Cognitive and Affective Neuroscience Center is funded by an NSF instrumentation grant (#0722874)

  • Siemens MAGNETOM Trio Tim (Total imaging matrix technology) 3 Tesla system scanner
  • Short (198 cm) whole-body superconductive 3T magnet

 

Simultaneous PET/MRI

  • MR-compatible LSO PET detectors inserted into the bore of the 3T MRI scanner, allowing simultaneous acquisition of MRI and list-mode PET data
  • Full radiosysnthesis, metabolite and plasma analysis through FERM and PERL

Unique Equipment

Unique Stony Brook equipment, developed by Drs. Paul Vaska and Daniela Schultz

Rat Conscious Animal Scanner (RatCAP)

  • allows for PET imaging of the rat brain while the rat is conscious and behaving
  • field of view covering the whole rat brain (38 mm transaxial, 18 mm axial)
  • spatial resolution of 1.5 mm FWHM

MR-Compatable RatCAP

An MR-compatible version of the RatCAP has been developed that can be installed within SBU's Bruker 9.4 T small-animal scanner

  • custom-built head holder and bed with capabilities for gas anesthesia and physiological monitoring
  • The PET system has similar performance as the RatCAP but also has inputs for respiratory and cardiac gating as necessary

Who We Are

We are a team of image analysts, programmers and engineers, focused on extracting the most accurate quantitative information from medical images. The facility is directed by Dr. Christine DeLorenzo, who holds a PhD in Biomedical Engineering and has 10+ years experience in medical image analysis.

Our infrastructure includes:

  • A 192-core, 384GB RAM cluster comprised of eight HP BL2x220c blade servers in an HP C7000 chassis is used for image processing and analysis
  • Over 10TB of data storage and servers
  • Repository of >1,500 PET and MRI images for hypothesis generation

Our Experience

We have extensive experience in the analysis of PET and MRI images including:

  • External funding (NIH and private foundations) for PET and MRI imaging
  • Presentation of methodolgy and results at international conferences
  • > 100 imaging publications
  • Development and validation of novel algorithms for image analysis
  • Implementation of standard techniques

Fees

Analysis Basic With Blood Analysis
PET & MRI
structural and diffusion only
$1,420 $1,545
PET & MRI
3 or more MRI sequences
$1,635 $1,883
MRI only $1,580
Dosimetry Study $26,500