The central theme of our research program is to identify and understand the molecular mechanisms and pathways in podocytes and neighboring cells that can be targeted to develop novel therapies for glomerular disease and chronic kidney disease. The additional translational focus is to correlate the basic research findings in patients, and to identify biomarkers for glomerular disease diagnosis and prognosis.
Targeted Research Areas of Focus:
- Mechanisms and selective modulation of nuclear receptor PPARy in podocyte biology and glomerular disease
- RNA-mediated mechanisms, such as roles of mRNA alternative splicing and polyadenylation and microRNA functions in podocyte biology and glomerular disease
- Mechanistic role of nucleoside transporter in mediating cardiotoxicity and nephrotoxicity imparted by cancer-treatment drugs
