Andrea Arreguin 
Education:
B.A. Boston University (2014)
Ph.D. Stony Brook University (2023)
Current Position:
8th Year MSTP
4th Year Medical Student
Advisor:
Holly Colognato
Graduate Program:
Neuroscience
Research Interest:
I am interested in understanding the role of stem cells in the adolescent and adult brain. I joined the lab of Dr. Holly Colognato to study neural stem cells and the extracellular matrix, which I hope to use to answer essential questions about the development of the nervous system. I will be exploring the roles of the dystrophin-glycoprotein complex and other extracellular matrix proteins in the postnatal subventricular zone neural stem cell niche.
In my free time, I enjoy running, cooking, traveling, and watching/playing sports. I am an avid tennis and soccer fan.
Publications:
(MSTP-supported publications indicated with an *)
Arreguin AJ*, Shao Z, Colognato H. Dmdmdx mice have defective oligodendrogenesis, delayed myelin compaction and persistent hypomyelination. Disease Models & Mechanisms. 2024 Apr 1;17(4).
Arreguin AJ*, Colognato H. “Brain dysfunction in LAMA2-related Congenital Muscular Dystrophy: lessons from human case reports and mouse models” Frontiers in Molecular Neuroscience. 13 (2020):18.
Negro A, Seidel J, Houben T, Yu E, Rosen I, Arreguin AJ, Yalcin N, Shorser-Gentile L, Pearlman L, Sadhegian HL, Chamberlin NL, Ayata C, Martelletti P, Moskowitz MA, Eikermann-Haerter K. Sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization. The Journal of Headache and Pain. 21.1 (2020): 1-11.
Palomo GM, Granatiero V, Kawamata H, Konrad C, Kim M, Arreguin AJ, Zhao D, Milner TA, Manfredi G. Parkin is a disease modifier in the mutant SOD1 mouse model of ALS. EMBO molecular medicine. 2018 Oct 1;10(10).
Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, et al. Rewiring of glutamine metabolism is a bioenergetic adaptation of human cells with mitochondrial DNA mutations. Cell metabolism. 2018 May 1;27(5):1007-25.
Konrad C, Kawamata H, Bredvik KG, Arreguin AJ, Cajamarca SA, Hupf JC, et al. Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients. Molecular Neurodegeneration. 2017;12(1):76.
Riar AK, Burstein SR, Palomo GM, Arreguin A, Manfredi G, Germain D. Sex specific activation of the ERalpha axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS. Human Molecular Genetics. 2017;26(7):1318-27.
Eikermann-Haerter, K., Arbel-Ornath, M., Yalcin, N., Yu, E. S., Kuchibhotla, K. V., Yuzawa, I., Hudry, E., Willard, C. R., Climov, M., Keles, F., Belcher, A. M., Sengul, B., Negro, A., Rosen, I. A., Arreguin, A., et al. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Annals of Neurology. 2015;78(2):193-210.
Park, L., Zhou, J., Zhou, P., Pistick, R., El Jamal, S., Younkin, L. Pierce, J., Arreguin, A., et al. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. PNAS 2013;110:3089-94.
