Alex Larkin

Education:Image: Alex Larkin

B.S. University of California, Santa Cruz (2011)

Current Position:

6th Year MSTP

4th Year Grad Student

Advisor:

Benjamin Martin, PhD

Graduate Program:

Pharmacology

Research Interest:

My current research interests include the mechanisms of cancer metastasis and the role of the immune system in extravasation and secondary tumor formation. In the Martin Lab I am looking at the role of cell cycle on the ability of cancer cells to invade the basement membrane as well the influences that macrophages have on the cancer cells. Previously I attended University of California, Santa Cruz and received my B.S. in Molecular, Cell, and Developmental Biology. At UCSC I did research in Dr. Bin Chen’s lab on the development of the neocortex. After graduation I worked at the UCSF Memory and Aging Center doing neuro autopsies and looking at the role of fork cells in Frontal Temporal Dementia. To pursue other research interests I began work at Stanford in the lab of Dr. Calvin Kuo on the development and regulation of intestinal stem cells.

Outside of the lab I enjoy playing with my dog, going on hikes, and reading.

Publications:

Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L,  Henning SJ, Wong MH, Kuo CJ. (2017) Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell, 21(1):78-90.e6.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ. (2017) Non-equivalence of Wnt and R-spondin ligands during Lgr5(+) intestinal stem-cell  self-renewal. Nature, 545(7653):238-242.

Eckler, M. J., Larkin, Kathryn A., McKenna, W. L., Katzman, S., Guo, C., Roque, R.,  Axel ViselJohn L R Rubenstein and Chen, B. (2014). Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. Neural Development9, 6.doi:10.1186/1749-8104-9-6.

McKenna, William L., Betancourt, Jennifer, Larkin, Kathryn A., Abrams, Benjamin, Guo, Chao, Rubenstein, John L. R., Chen, Bin. (2011) Tbr1 and Fezf2 Regulate Alternate Corticofugal Neuronal Identities during Neocortical Development. The Journal of Neuroscience 31(2):549-564.