Lillian Talbot
Education:
B.S. University of Connecticut (2014)
Current Position:
8th Year MSTP
4th Year Medical Student
Advisor:
Joshua Dubnau, PhD
Graduate Program:
Neuroscience
Research Interest:
Amyotrophic lateral sclerosis (ALS) is a progressive, presently incurable neurodegenerative
disorder primarily affecting upper and lower motor neurons. The clinical, pathological and genetic diversity associated with ALS has led to the idea that ALS is a complex syndrome caused by alterations in multiple molecular processes. Early diagnosis is complicated by an inability to distinguish initial ALS symptoms from other neurological disorders. Patients undergo a battery of laboratory tests and physical examinations only to be given a probable diagnosis with no definitive etiology. With this in mind, we undertook a clinical study to identify novel RNA biomarkers in the cerebrospinal fluid (CSF) of ALS patients that may lead to improvements in diagnosis, treatment, and a clearer understanding of the disease’s pathophysiology. Outside of medicine and science, I love a good adventure. You’ll find me exploring nature, traveling, listening to live music, and cooking for my friends and family.
Publications:
Talbot LR, Romeiser JL, Spitzer ED, et al. Prevalence of IgM and IgG antibodies to SARS-CoV-2 in health care workers at a tertiary care New York hospital during the Spring COVID-19 surge. Perioper Med (Lond). 2021;10(1):7. Published 2021 Mar 2. doi:10.1186/s13741-021-00177-5
Keegan RM, Talbot LR, Chang YH, Metzger MJ, Dubnau J. Intercellular viral spread and intracellular transposition of Drosophila gypsy. PLoS Genet. 2021;17(4):e1009535. Published 2021 Apr 22. doi:10.1371/journal.pgen.1009535
Bennett-Guerrero E, Romeiser JL, Talbot LR, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial. Crit Care Med. 2021;49(7):1015-1025.
Carter JA, Freedenberg AT, Romeiser JL, Talbot LR et al. Impact of serological and PCR testing requirements on the selection of COVID-19 convalescent plasma donors. Transfusion. 2021;61(5):1461-1470. doi:10.1111/trf.16293
Duffy EI, Garry J, Talbot L, et al. A pilot study assessing the spiritual, emotional, physical/environmental, and physiological needs of mechanically ventilated surgical intensive care unit patients via eye tracking devices, head nodding, and communication boards. Trauma Surg Acute Care Open. 2018;3(1):e000180. Published 2018 Sep 19. doi:10.1136/tsaco-2018-000180
Curran SA, Shyer JA, St Angelo ET, Talbot LR, et al. Human Dendritic Cells Mitigate NK-Cell Dysfunction Mediated by Nonselective JAK1/2 Blockade. Cancer Immunol Res. 2017;5(1):52-60. doi:10.1158/2326-6066.CIR-16-0233
Acabchuk R, Briggs DI, Angoa-Pérez M, Powers M, Wolferz R Jr, Soloway M, Stern M, Talbot LR, et al. Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus. Concussion. 2016;1(3):CNC13. doi:10.2217/cnc-2015-0001
