Philip Moresco
Education:
B.A. Mount Saint Mary College (2016)
Current Position:
7th Year MSTP
5th Year Grad Student
Advisor:
Douglas Fearon
Graduate Program:
Genetics
Research Interest:
My primary research interests reside in the complex interaction between the immune system and cancer. The body has evolved an incredible repertoire of mechanisms to fight cancer, but clinically presenting cases are those that have escaped immune control. I am interested in identifying ways in which cancer bypasses the immune system, and then trying to target them therapeutically. My previous research experience includes work in modulating tumor immunobiology through cell depletion in the attempt to identify the mechanism of pancreatic ductal adenocarcinoma immune evasion.
Awards:
2022 NIH NRSA F30; National Cancer Institute, Bethesda, MD
Publications:
Humann J, Mann B, Gao G, Moresco P, Ramahi J, Loh LN, Farr A, Hu Y, Durick-Eder K, Fillon SA, Smeyne RJ, Tuomanen EI. (2016) Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host Microbe. 19(3):388-99
Wang Z, Moresco P, Yan R, Li J, Gao Y, Biasci D, Yao M, Pearson J, Hechtman JF, Janowitz T, Zaidi RM, Weiss MJ, Fearon DT. Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2119463119.
Yan R*, Moresco P*, Gegenhuber B, Fearon DT. T cell-mediated development of stromal fibroblasts with an immune-enhancing chemokine profile. Cancer Immunol Res. 2023 May 22:CIR-22-0593. *Contributed equally
