B.S. University of California, Berkeley (2017)
4th Year MSTP
2nd Year Grad Student
Shaoyu Ge, PhD, Neurobiology & Behavior
In general, I am interested in using stem cells as a therapeutic approach to disease models, especially using mice. My previous research experience has had a diverse range of subjects. During my undergraduate years, I focused on the bi-directional cell fate potential in pluripotent stem cells, identifying that the deficiency of microRNA-34a expanded cell fate potential. After graduation, I also conducted research on investigating the inhibitory interneuronal dysfunction in Alzheimer’s disease by targeting interneurons as a therapeutic approach using cell therapy, genetics, drugs, and optogenetic applications. I hope to further my studies in both neuroscience and stem cells in mouse disease models during my time at Stony Brook.
Chen, A.P., Chen, L., Kim, T. A., Xiong, Q. Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease. Biomedicines, 9(6), 647 (2021). Doi: 10.3390/biomedicines9060647
Kim, T. A., Chen, L., Ge, S. The Interplay of Neurovasculature and Adult Hippocampal Neurogenesis. Neuroscience letters, 136071. (2021) doi: 10.1016/j.neulet.2021.136071; PMID: 34147540.
Hanson, J. E.*, Ma, K.*, Elstrott, J.*, Weber, M.*, Saillet, S.*, Khan, A. S., Simms, J., Liu, B., Kim, T. A., Yu, G. Q., Chen, Y., Wang, T. M., Jiang, Z., Lieder, B. M., Deshmukh, G., Solanoy, H., Chan, C., Sellers, B. D., Volgraf, M., Schwarz, J. B., Hackos, D. H., Weimer, R. M., Sheng, M., Gill, T. M., Scearce-Levie, K., Palop, J. J. GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models. Cell Report. doi: 10.1016/j.celrep.2019.12.030.
Choi, Y. J.*, Lin, C. P.*, Risso, D.*, Chen, S., Kim, T. A., Than, M. H., Li, J. G., Wu, Y., Chen, C., Xuan, Z., Macfarlan, T., Peng, W., Lloyd, K. K., Kim, S. Y., Speed, T. P., He, L. Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Science355, 596 (2017). doi: 10.1126/science.aag1927; pmid:22020437 (*equal contribution)