Dillon M. Voss
Education:
B.S. California University of Pennsylvania (2013)
M.S. Case Western Reserve University (2017)
Current Position:
6th Year MSTP
4th Year Graduate Student
Advisor:
Adrian Krainer, CSHL
Graduate Program:
Genetics
Research Interest:
My broad research interests include studying how the tumor microenvironment alters and maintains cancer stem cell (CSC) signaling pathways, as well as integrating omics-driven research with bioinformatics to improve how tumors are characterized and treated. My previous work mainly involved studying the hypoxic tumor microenvironment of high-grade gliomas, and identifying small molecule compounds that disrupted various signaling nodes of common CSC maintenance pathways. I look forward to developing a more translational approach to my research, with hopes to both assist cancer patients as they navigate clinical trials, as well as use these experiences to guide my search for new therapies.
Publications:
# Wan, L., Kral, A. J., Voss, D.M, Krainer, A. R. (2023) Preclinical Screening of Splice-Switching Antisense Oligonucleotides in PDAC Organoids. bioRxiv, 2023.2003.2031.535161.
# Ma, W.K., Voss, D.M., Scharner, J., Costa, A.S.H., Lin, K.-T., Jeon, H.Y., Wilkinson, J.E., Jackson, M., Rigo, F., Bennett, C.F., Krainer, A.R. (2022). ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth. Cancer Res. 82, 900-915.
# Kim, Y.J., Sivetz, N., Layne, J., Voss, D.M., Yang, L., Zhang, Q., and Krainer, A.R. (2022). Exon-skipping antisense oligonucleotides for cystic fibrosis therapy. PNAS. 119, e2114858118.
Voss, D.M.*, Sloan, A.*, Spina, R., Ames, H.M., and Bar, E.E. (2020). The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness. Cancer Res. 80, 4681-4692.
Spina, R., Voss, D.M., Yang, X., Sohn, J.W., Vinkler, R., Schraner, J., Sloan, A., Welford, S.M., Avril, N., Ames, H.M., Woodworth, G.F., Bar, E.E. (2020). MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner. Neurooncol Adv. 2, vdz062.
Spina, R., Voss, D.M., Asnaghi, L., Sloan, A., and Bar, E.E. (2018). Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells. J Vis Exp.
Voss, D.M., Spina, R., Carter, D.L., Lim, K.S., Jeffery, C.J., and Bar, E.E. (2017). Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 7, 4292.
Spina, R., Voss, D.M., Asnaghi, L., Sloan, A., and Bar, E.E. (2016). Atracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells. Oncotarget. 7, 459-472.
* Both authors contributed equally to this work.
# Indicates publication during MSTP training.
