Santiago Espinosa de los Reyes
B.S. University of Richmond (2017)
2nd Year MSTP
2nd Year Medical Student
Currently, I am interested in understanding the wide variety of regulatory mechanisms that promote cancer development and metastasis. My previous research has focused on identifying mechanosensitive proteins that can potentially alter gene expression by shuttling into the nucleus depending on the stiffness of the cellular environment. Additionally, I worked on elucidating the structural landscape of F-actin under different nucleotide states in order to better understand how interactions between F-actin and actin binding proteins are regulated to transduce mechanical forces into biochemical signaling cascades.
Mei, L., de Los Reyes, S. E., Reynolds, M. J., Leicher, R., Liu, S., & Alushin, G. M. (2020). Molecular mechanism for direct actin force-sensing by α-catenin. Elife, 9, e62514.
Sun, X., Phua, D. Y., Axiotakis Jr, L., Smith, M. A., Blankman, E., Gong, R., de los Reyes, S. E., ... & Alushin, G. M. (2020). Mechanosensing through direct binding of tensed F-actin by LIM domains. Developmental Cell, 55(4), 468-482.
Sarker, M., Lee, H. T., Mei, L., Krokhotin, A., de los Reyes, S. E., Yen, L., ... & Campbell, S. L. (2019). Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies. Journal of molecular biology, 431(8), 1604-1618.
Gilmore, S. P., Gonye, A. L., Li, E. C., de los Reyes, S. E., Gupton, J. T., Quintero, O. A., & Fischer- Stenger, K. (2018). Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264. 7 macrophages. Chemico-biological interactions, 280, 109-116.