Rohini Guin
Education:
B.S. Emory University (2020)
Current Position:
3rd Year MSTP
1st Year Graduate Student
Advisor:
Tobias Janowitz
Graduate Program:
Genetics
Research Interests:
I am primarily interested in applying immunomodulatory approaches to cancers, transplants, and infectious diseases. My prior research evaluated the role of mTOR complexes in cancers and graft-versus-host disease using CRISPR-knockout cells and mouse models. My undergraduate research involved developing personalized therapeutic vaccines with metastatic tumor-specificity using a murine breast cancer model. I aim to synergize these experiences in my dissertation work, using preventive and treatment interventions to tune the immune system across disease contexts.
Publications:
Munoz LE, Huang L, Bommireddy R, Sharma R, Monterroza L, Guin RN, Samaranayake SG, Pack CD, Ramachandiran S, Reddy SJC, Shanmugam M and Selvaraj P. Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy. Journal for ImmunoTherapy of Cancer. 2021. 9(11).
Huang L, Bommireddy R, Munoz LE, Guin RN, Wei C, Ruggieri A, Menon AP, Li X, Shanmugam M, Owonikoko TK, Ramalingam SS, Selvaraj P. Expression of tdTomato and
luciferase in a murine lung cancer alters the growth and immune microenvironment of the tumor. PLOS ONE. 2021. 16(8).
