Ian Outhwaite
Education:
B.A. Williams College (2017)
Advisor:
Markus Seeliger
Biochemistry & Structural Biology
Our work investigates mechanisms of resistance to small-molecule drugs used in the treatment of human cancers, and approaches to overcome resistance using combinations of small-molecule inhibitors or through new chemical designs.
Additional Research Support:
2024 NIH-NCI NRSA F30 Research Fellowship (NIH 1F30CA281272-01A1)
2022 Chemical Biology Research Fellowship (NIH T32-GM136572)
Publications:
* co-equal contribution
# co-corresponding author
(2026) Stevenson JW, Lou KJ, Reynolds JA, Outhwaite IR, Huang K, Sokirniy I, Peterson SKY, Munir AZ, Wang CD, Inam H, Gebauer EL, Leyte-Vidal A, Rees MG, Ronan MM, Salangsang F, Zeng Y, Steri V, Roth JA, Shah NP, Echeverria I, Sali A, Zhang Z, Moslehi JJ, Seeliger MA, Pritchard JR, Shokat KM. A design approach to bitopic kinase inhibitors. Nature. Accepted August 2026.
(2025) Outhwaite IR*, Kwan I*, Leyte-Vidal A, Shah NP, Bahar I, Seeliger MA. Resistance to Allosteric Inhibitors. J Mol Biol. 2025 Apr 10:169133. doi: 10.1016/j.jmb.2025.169133
(2025) Jennings RB*, Outhwaite IR*, Granek I, Haq F. The Effects of the Physical and Professional Workplace Environments on the Well-Being of Nursing Staff. Am J Nurs. doi: https://doi.org/10.1097/AJN.0000000000000033
(2024) Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP. (2024). Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia. doi: https://doi.org/10.1038/s41375-024-02353-0
(2024) Radin, DP, Shifman, S, Outhwaite, IR, Sharma, A, Bases, R, Seeliger, MA, Tsirka, SE. Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. JPET. https://doi.org/10.1124/jpet.123.002021
(2023) Outhwaite IR, Singh S, Berger B.-T., Knapp S, Chodera JD, Seeliger MA. Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. eLife. doi: https://doi.org/10.7554/eLife.86189
(2023) Outhwaite IR, Seeliger MA. Kinase Activity: Probing conformational dynamics to understand kinase inhibition. eLife. doi: https://doi.org/10.7554/eLife.92753 [Insight article]
(2023) Mingione VR*, Paung Y*, Outhwaite IR*#, Seeliger MA. Allosteric regulation and inhibition of protein kinases. Biochem Soc Trans. 27 February 2023; 51 (1): 373–385. doi: https://doi.org/10.1042/BST20220940
(2022) Peterson AA, Rangwala AM, Thakur MK, Ward PS, Hung C, Outhwaite IR et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. https://doi.org/10.1038/s41589-022-01116-1
(2022) Phillips HE, Jennings RB, Outhwaite IR et al. Motivation to Impact: Medical Student Volunteerism in the COVID 19 Pandemic. Med Sci Educ. doi: https://doi.org/10.1007/s40670-022-01639-1
(2020) Hou X*, Outhwaite IR*, Pedi L, Long SB. Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. eLife. doi: https://doi.org/10.7554/eLife.62772