Erica Nebet
Education:
A.A. Bard College (2016)
B.S. New York University (2020)
Advisor:
Lonnie Wollmuth
Graduate Program:
Neuroscience
Research Interest:
I have long been interested in the development of innovative treatments that target the underlying causes of neurological disorders, with a particular emphasis on epilepsy. As an undergraduate in the Tsien Lab, I investigated the balance of excitatory and inhibitory activity in the hippocampus, a common seizure focus in the brain, as well as the mechanism via which cannabidiol (CBD) produces an anti-seizure effect; excitingly, CBD is now offered as a treatment for patients with refractory epilepsy. Currently, for my thesis work in the Wollmuth Lab, I am studying the role of the NMDA receptor subunits in neurodevelopment and seizure pathogenesis, hoping to uncover novel targets to treat seizures due to developmental dysregulation.
Publications:
Kysilov, B., Prasad, R., Nebet, E. R., Bennett, J., Amin, J. B., Zhou, H-X. and Wollmuth, L.P. Subconductance states in NMDA receptor variants are Ca2+ impermeable and act at the M2 loop. Nature Communications, In Review.
Nebet, E.R., Aprea, C., Zoodsma, J.D., Raab, W.J., Sirotkin, H.I., and Wollmuth, L.P. Conservation of human NMDA receptor subunits and disease variants in zebrafish. BMC Genomics. 2025 Nov; 13;26(1):1042.
Chamberland S., Grant G., Machold R., Nebet E.R., Tian G., and Tsien R.W. Functional specialization of hippocampal somatostatin-expressing interneurons. Proceedings of the National Academy of Sciences. 2024 Apr; 121(17):e2306382121. (PMCID: PMC11047068)
Chamberland S., Nebet E.R., Valero M., and Tsien R.W. Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons. Neuron. 2023 Feb; S0896-6273(23)00065-X. (PMCID: PMC10121938)
Rosenberg E., Chamberland S., Bazelot M., Nebet E.R., Wang X., and Tsien R.W. Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity. Neuron. 2023 Feb; S0896-6273(23)00066-1.
Conference Posters/Presentations:
NMDA receptors in neurodevelopment and seizure pathogenesis.
Invited presentation, Curing the Epilepsies 2026: New Horizons, National
Institutes of Health in Bethesda, Maryland. June 2026.
NMDA receptors in neurodevelopment and seizure pathogenesis.
Invited presentation, Society for Neuroscience, San Diego, California. November
2025.
NMDA receptors in neurodevelopment and seizure pathogenesis.
Invited talk, GRICON25, Orlando, Florida. July 2025.
Characterization of disease-associated variants in the NMDA receptor M3 segment.
Invited presentation, 38th Annual MD-PhD National Student Conference, Copper
Mountain, CO. July 2023.
Mechanisms constraining the recruitment of perisomatic and dendritic innervating
interneurons in hippocampal CA1.
Invited presentation, Society for Neuroscience, Chicago, Illinois. October 2019.