Erica Nebet
Education:
A.A. Bard College (2016)
B.S. New York University (2020)
Current Position:
3rd Year MSTP
1st Year Graduate Student
Advisor:
Lonnie Wollmuth
Graduate Program:
Neuroscience
Research Interest:
I have long been interested in the development of innovative treatments that target the underlying causes of neurological disorders, with a particular emphasis on epilepsy. As an undergraduate in the Tsien Lab, I investigated the balance of excitatory and inhibitory activity in the hippocampus, a common seizure focus in the brain, as well as the mechanism via which cannabidiol (CBD) produces an anti-seizure effect; excitingly, CBD is now offered as a treatment for patients with refractory epilepsy. Currently, for my thesis work in the Wollmuth Lab, I am studying the role of the NMDA receptor subunits in neurodevelopment and seizure pathogenesis, hoping to uncover novel targets to treat seizures due to developmental dysregulation.
Publications:
Chamberland S., Grant G., Machold R., Nebet E.R., Tian G., and Tsien R.W. Functional specialization of hippocampal somatostatin-expressing interneurons. Proceedings of the National Academy of Sciences. 2024 Apr; 121(17):e2306382121. (PMCID: PMC11047068)
Chamberland S., Nebet E.R., Valero M., and Tsien R.W. Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons. Neuron. 2023 Feb; S0896-6273(23)00065-X. (PMCID: PMC10121938)
Rosenberg E., Chamberland S., Bazelot M., Nebet E.R., Wang X., and Tsien R.W. Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity. Neuron. 2023 Feb; S0896-6273(23)00066-1.
