Madaleine Niznikiewicz
Education:
B.S. University of Massachusetts, Amherst (2019)
Current Position:
3rd Year MSTP
1st Year Graduate Student
Advisor:
Brian Sheridan
Graduate Program:
Microbiology & Immunology
Research Interests:
I am interested in neurodegeneration and the role of the immune system in this process. My most recent research sought to elucidate, through application of genetic and biochemical techniques in Saccharomyces cerevisiae, the mechanisms by which prion formation is prevented, and controlled, by the eukaryotic cell. Specifically, I identified genetic relationships between a novel component of the yeast anti-prion system and other known and unknown actors found in previous research. In my earlier research I helped examine the role of inflammation in sleep.
Publications:
Wickner RB, Edskes HK, Son M, Wu S, Niznikiewicz M. Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip. Curr Genet. 2021 Jul 28. doi: 10.1007/s00294-021-01203-1. Epub ahead of print. PMID: 34319422.
Wickner RB, Edskes HK, Son M, Wu S, Niznikiewicz M. How Do Yeast Cells Contend with Prions? International Journal of Molecular Sciences. 2020; 21(13):4742. https://doi.org/10.3390/
Zielinski, M. R., Gerashchenko, D., Basheer, R., Strecker, R. E., Niznikiewicz, M. M., & Johnston, A. M. (2018). 0033 Sleep Loss-induced Anxiety- And Depressive-like Behaviors Are Attenuated In Mice Lacking Nlrp3 Inflammasomes. Sleep, 41(suppl_1), A13–A14. https://doi.org/10.1093/sleep/
Gerashchenko, D., Niznikiewicz, M. M., Johnston, A. M., Basheer, R., Strecker, R. E., & Zielinski, M. R. (2018). 0032 Absence Of Nlrp3 Inflammasomes Reduces Cognitive Performance Impairments Induced By Sleep Loss. Sleep, 41(suppl_1), A13–A13. https://doi.org/10.1093/sleep/
Johnston, A. M., Niznikiewicz, M. M., Gerashchenko, D., Strecker, R. E., Basheer, R., & Zielinski, M. R. (2018). 0031 Nlrp3 Inflammasome Mediates Il-18 And Il-18 Receptor Responses To Sleep Loss. Sleep, 41(suppl_1), A13–A13. https://doi.org/10.1093/sleep/
Niznikiewicz, M. M., Gerashchenko, D., McKenna, J. T., Basheer, R., Strecker, R. E., McCarley, R. W., & Zielinski, M. R. (2017). 0021 SLEEP DEPRIVATION ACTIVATES NLRP3 INFLAMMASOMES IN NEURONS AND GLIA. Sleep, 40(suppl_1), A8–A8. https://doi.org/10.1093/
