B.S. UCLA (2019)
1 st Year MSTP
In general, I am interested in the integration of large multi-omic datasets with clinical data points to inform the development of personalized, targeted therapeutics, preventative treatments, and improved diagnostic tools. During my undergraduate years, my research focused on the influence of epigenetics on pre-mRNA splicing. Most recently, I have been involved in the development of cancer immunotheraputics that target cancer-specific alternative splicing events.
Leung, C. S., Douglass, S. M., Morselli, M., Obusan, M. B., Pavlyukov, M. S., Pellegrini, M., & Johnson, T. L. (2019). H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome Assembly. Cell Reports, 27(13), 3760 3769.e4. https://doi.org/10.1016/j.celrep.2019.05.100
Nesterenko, P. A., McLaughlin, J., Cheng, D., Bangayan, N. J., Sojo, G. B., Seet, C. S., Qin, Y., Mao, Z., Obusan, M. B., Phillips, J. W., & Witte, O. N. (2021). Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2021190118
Wang, L., Smith, B. A., Balanis, N. G., Tsai, B. L., Nguyen, K., Cheng, M. W., Obusan, M. B., Esedebe, F. N., Patel, S. J., Zhang, H., Clark, P. M., Sisk, A. E., Said, J. W., Huang, J., Graeber, T. G., Witte, O. N., Chin, A. I., & Park, J. W. (2020). A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proceedings of the National Academy of Sciences, 117(1), 563–572.