Image: Alex TerryAlex Terry

Education:
B.A. University of Chicago (2014)

Ph.D. University of Illinois-Chicago (expected 2021)

Current Position:

3rd Year Medical Student

Advisor:

Dr. Nissim Hay (UIC)

Graduate Program:

Biochemistry and Molecular Genetics (UIC)

Research Interest:

Since college, I have been interested in cancer metabolism, specifically understanding how tumor cells alter their metabolism to promote survival during nutrient deprivation. My undergraduate work focused on BNIP3, a mitophagy-adaptor protein, in hepatocellular carcinoma. In my graduate work, I studied CD36, a membrane protein implicated in the transport and utilization of lipid substrates. We found that CD36 supports lipid homeostasis through selective uptake of mono-unsaturated fatty acids (MUFAs). This function appears to be most important in settings when endogenous production of MUFAs is inhibited, or when exogenous saturated fatty acids are more abundant (e.g. obesity). Beyond cancer biology, I have also spent considerable time thinking about how Cas9 and sequential activation of guide RNAs can control lineage determination during differentiation.

Publications:

Clarke, R., Terry, A. R., Pennington, H., Hasty, C., MacDougall, M. S., Regan, M., & Merrill, B. J. (2021). Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities. Molecular cell, 81(2), 226–238.e5. https://doi.org/10.1016/j.molcel.2020.12.003

Ariss, M. M., Terry, A. R., Islam, A., Hay, N., & Frolov, M. V. (2020). Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain. Journal of cell science, 133(19), jcs250837. https://doi.org/10.1242/jcs.250837

Terry, A. R., & Hay, N. (2019). Fuelling cancer cells. Nature reviews. Endocrinology, 15(2), 71–72. https://doi.org/10.1038/s41574-018-0146-6

Pusec, C. M., De Jesus, A., Khan, M. W., Terry, A. R., Ludvik, A. E., Xu, K., Giancola, N., Pervaiz, H., Daviau Smith, E., Ding, X., Harrison, S., Chandel, N. S., Becker, T. C., Hay, N., Ardehali, H., Cordoba-Chacon, J., & Layden, B. T. (2019). Hepatic HKDC1 Expression Contributes to Liver Metabolism. Endocrinology, 160(2), 313–330. https://doi.org/10.1210/en.2018-0088

DeWaal, D., Nogueira, V., Terry, A. R., Patra, K. C., Jeon, S. M., Guzman, G., Au, J., Long, C. P., Antoniewicz, M. R., & Hay, N. (2018). Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nature communications, 9(1), 446. https://doi.org/10.1038/s41467-017-02733-4