Danielle Xie
Education:
B.A. Bryn Mawr College (2019)
Advisor:
Charles Vorkas
Graduate Program:
Microbiology & Immunology
Research Interest:
I would like to develop expertise in the field of immune therapeutics and gain a better understanding of how we can guide the immune system toward desired responses. At the NIH, I studied how broadly neutralizing antibody responses develop in HIV infection, aiming to apply that knowledge towards vaccines or improved immunologic therapies for HIV. Building on this immunology background, I joined the Vorkas laboratory, where my graduate work is focused on identifying and characterizing novel MR1-restricted T cell repertoires and understanding how they respond in clinically relevant contexts, including infection, autoinflammation, and cancer.
Publications:
(8) Choi W, Li D, McLaughlin CT, Peroumal D, Shiomitsu KP, Moschetta GA, Rahimi H, Wang S, Biswas K, Xie D, Vorkas CK, Biswas PS*. Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues. Cell Host & Microbe. In press (2026).
(7) Wu, D., Matsuda, T., Xie, D. et al. NOD2-Related Multisystem Inflammatory Disorders and Recent Advances. Curr Rheumatol Rep 28, 5 (2026). https://doi.org/10.1007/s11926-026-01212-4
(6) Kaur R, Xie D, Pradhan A, Mehanna N, Li K, Aubé J, Rosati B, Carlson D, Lee CY, Vorkas CK. CD4⁺ mucosal-associated invariant T cells express highly diverse T cell receptors. Journal of Immunology. 2025;214(12):3260–3272. doi:10.1093/jimmun/vkaf260.
(5) Cale EM, Shen CH, Olia AS, Radakovich NA, Rawi R, Yang Y, Ambrozak DR, Bennici AK, Chuang GY, Crooks ED, Driscoll JI, Lin BC, Louder MK, Madden PJ, Messina MA, Osawa K, Stewart-Jones GBE, Verardi R, Vrakas Z, Xie D, Zhang B, Binley JM, Connors M, Koup RA, Pierson TC, Doria-Rose NA, Kwong PD, Mascola JR, Gorman J. A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies. Cell Rep. 2024 Dec 24; 43(12):115010.
(4) Ware, M., J. Kaar, C. Diniz Behn, K. Bartlette, A.-M. Carreau, D. Lopez‐Paniagua, A. Scherzinger, Xie D, H. Rahat, Y. Garcia‐Reyes, K. Nadeau and M. Cree‐Green (2022). & "Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity." Obesity 30: 191-200.
(3) Bartlette, K., A.-M. Carreau, Xie D, Y. Garcia-Reyes, H. Rahat, L. Pyle, K. Nadeau, M. Cree-Green and C. Diniz Behn (2021). "Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration." Metabolism Open 9: 100078.
(2) Carreau, A.-M., Xie D, Y. Garcia‐Reyes, H. Rahat, K. Bartlette, C. Diniz Behn, L. Pyle, K. Nadeau and M. Cree‐Green (2020). "Good agreement between hyperinsulinemic‐euglycemic clamp and 2h oral minimal model assessed insulin sensitivity in adolescents." Pediatric Diabetes 21.
(1) Cree-Green, M., Xie D, H. Rahat, Y. Garcia-Reyes, B. Bergman, A. Scherzinger, C. Diniz Behn, C. Chan, M. Kelsey, L. Pyle and K. Nadeau (2018). "Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls." Journal of the Endocrine Society 2.
Conference Posters/Presentations:
(14) Talk, “MR1 restricted immunity in hematologic malignancy.” Stony Brook Cancer Center Retreat. Port Jefferson, NY. July 2025.
(13) Poster, “Premature Immune Aging in Survivors of Childhood Hematologic Malignancies.” ASH annual meeting. San Diego, CA. December 2024.
(12) Poster, “Inflammatory T Cell Expansion in Yao Syndrome.” American College of Rheumatology Annual Convergence Meeting. Washington, DC. November 2024.
(11) Poster, “The Role of MR1 Restricted T Cell Immunity in Blood Cancers.” NYC-Wide MD-PhD Conference. New York City, NY. November 2024.
(10) Poster, “MR1 Restricted T cell Subsets in Blood Cancers.” Department of Medicine Research Symposium. Stony Brook, NY. September 2024.
(9) Poster, “The Role of Folate Derived Metabolites in Modulating MR1-Restricted T Cell Immunity.” Stony Brook Cancer Center Research Symposium. Port Jefferson, NY. June 2024.
(8) Poster, “MR1 Restricted Immunity in Hematologic Cancers.” Department of Medicine Research Symposium. Stony Brook, NY. September 2023.
(7) Poster, “Designing Glycan-Modified Immunogens to Engage Precursors of the 35O22 Class of HIV Broadly Neutralizing Antibodies.” Postbaccalaureate Poster Day. (*virtual, via WebEx), Bethesda, MD. April 2021.
(6) Poster, “HIV-1 trimer-interface antibodies 35O22 and VRC44 are members of a reproducible class.” Postbaccalaureate Poster Day (*virtual, via WebEx), Bethesda, MD. April 2020.
(5) Oral Abstract, “Validation of Surrogate Models to Assess Tissue and Whole-Body Insulin Resistance in High-Risk Adolescent Girls.” American Federation of Medical Research Eastern Regional Meeting, Philadelphia, PA. March 2019.
(4) Oral Abstract, “Validation of Surrogate Models to Assess Tissue and Whole-Body Insulin Resistance in High-Risk Adolescent Girls.” Endocrine Society Annual Meeting + AEPCOS Meeting, New Orleans, LA. March 2019.
(3) Poster, “Validation of Surrogate Models to Assess Tissue and Whole-Body Insulin Resistance in High-Risk Adolescent Girls.” Undergraduate Research Symposium, Icahn School of Medicine at Mount Sinai, New York, NY. October 2018.
(2) Poster, “In Adolescent Girls, an Oral Minimal Model Provides a Good Surrogate Measure of Hepatic and Muscle Insulin Sensitivity.” Pediatric Endocrinology Research Symposium, Children’s Hospital Colorado, Aurora, CO. July 2018.
(1) Presentation, “Glucose Peak Time during OGTT is Most Predictive of Prediabetes and MetS Risk in Obese Girls.” Endocrinology Department Meeting, Children’s Hospital Colorado, Aurora, CO. July 2017.