B.A. Vassar College (2018)
3rd Year MSTP
1st Year Graduate Student
Molecular & Cellular Pharmacology
Tyrosine kinases are important regulators of growth and differentiation in normal mammalian cells. They are normally under tight control and have low basal activity and activated transiently in response to specific stimuli. Inappropriate activation of tyrosine kinase signaling by mutation, overexpression, or chromosomal rearrangement often occurs in human cancers. The major research goals of our laboratory are to understand how tyrosine kinases recognize their target proteins in cells, determine the regulatory mechanisms that control tyrosine kinase activity, and develop strategies to block the action of oncogenic tyrosine kinases.
Crooks DR, Maio N, Lang M, Ricketts CJ, Vocke CD, Gurram S, Turan S, Kim YY, Cawthon GM, Sohelian F, De Val N, Pfeiffer RM, Jailwala P, Tandon M, Tran B, Fan TW, Lane AN, Ried T, Wangsa D, Malayeri AA, Merino MJ, Yang Y, Meier JL, Ball MW, Rouault TA, Srinivasan R, Linehan WM. Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer. Sci Signal. 2021 Jan 5;14(664):eabc4436.
Kim YY, Tanski JM. Crystal structure of a rare trigonal bipyramidal titanium(IV) coordination complex: tri-chlorido-(3,3'-di-tert-butyl-2'-hy-droxy-5,5',6,6'-tetra-methyl-1,1'-biphenyl-2-olato-κO2)(tetra-hydro-furan-κO)-titanium(IV). Acta Crystallogr E Crystallogr Commun. 2017 Jan 1;73(Pt 1):88-91.