Yunyoung Kim
Education:
B.A. Vassar College (2018)
Current Position:
5th Year MSTP
3rd Year Graduate Student
Advisor:
Todd Miller
Graduate Program:
Molecular & Cellular Pharmacology
Research Interest:
Tyrosine kinases are important regulators of growth and differentiation in normal mammalian cells. Inappropriate activation of tyrosine kinase signaling by mutation, overexpression, or chromosomal rearrangement often occurs in human cancers. Our major research goals are to understand how tyrosine kinases recognize their target proteins in cells, to determine the regulatory mechanisms that control tyrosine kinase activity, and to develop strategies to block the action of oncogenic tyrosine kinases.
Publications:
Kim, Y., Ahmed, S., & Miller, W. T. (2023). Colorectal cancer-associated mutations impair EphB1 kinase function. The Journal of biological chemistry (in press).
Kan, Y., Paung, Y., Kim, Y., Seeliger, M. A., & Miller, W. T. (2023). Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry, 62(6), 1124–1137.
Crooks, D. R., Maio, N., Lang, M., Ricketts, C. J., Vocke, C. D., Gurram, S., Turan, S., Kim, Y. Y., Cawthon, G. M., Sohelian, F., De Val, N., Pfeiffer, R. M., Jailwala, P., Tandon, M., Tran, B., Fan, T. W., Lane, A. N., Ried, T., Wangsa, D., Malayeri, A. A., … Linehan, W. M. (2021). Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer. Science signaling, 14(664), eabc4436.
Kim, Y. Y., & Tanski, J. M. (2017). Crystal structure of a rare trigonal bipyramidal titanium(IV) coordination complex: tri-chlorido-(3,3'-di-tert-butyl-2'-hy-droxy-5,5',6,6'-tetra-methyl-1,1'-biphenyl-2-olato-κO2)(tetra-hydro-furan-κO)-titanium(IV). Acta crystallographica. Section E, Crystallographic communications, 73(Pt 1), 88–91.
