Obstetrics
HOPE (Heart Outcomes in Pregnancy Expectations) (Co-PI: Cecila Avila)
Where:
Recruiting outpatient pregnant women with heart conditions
Inclusion criteria:
1. 18 years or older
2. Any pregnant person at any point in gestation (with singleton or multiple gestation) prior to delivery.
3. English and/or Spanish speaking
4. Attends at least one cardio obstetrics clinic visit
5. Must have one or more of the conditions within the following 6 categories
a. Congenital or structural heart disease
b. Aortopathies
c. Arrhythmia
d. Cardiomyopathies and heart failure
e. Coronary disease
f. Other
Exclusion criteria:
1. Previously enrolled in HOPE (current study).
2. Unable to participate in follow-up
a. Incarcerated or current prisoner
b. Current diagnosis of dementia
c. Subjects without a way to contact for follow-up
3. Refused participation in the study
4. Unable to consent for self
5. Traumatic aortic disease
6. Perpartum cardiomyopathy diagnosed in the current pregnancy (new diagnosis)
Contact: alessa.ramosvargas@stonybrookmedicine.edu
IMPAACT 2041 (PI: Sharon Nachman)
Where:
Recruiting pregnant patient with hepatitis C virus (HCV) to describe pharmacokinetics (PK) and safety of glecaprevir/pibrentasvir (GLE/PIB).
Inclusion criteria:
Age: 16-45 years of age (inclusive)
GA: 14-32 weeks gestation, SINGLETON (no known anomalies, no growth restriction)
HCV status: At screening, detectable HCV RNA test result based on testing of a specimen collected within 30 days prior to enrollment.
Other labs within 30 days prior to enrollment:
• Hepatitis B surface antigen negative
• AST/ALT (<10.0 x ULN)
• Hemoglobin (≥8.5 g/dL)
• Creatinine (≤1.8 x ULN)
• INR (<1.5 x ULN)
• Platelet count (≥100,000 cells/mm3)
• Total bilirubin (<1.6 x ULN)
• HIV status
Exclusion criteria:
- Previous treatment for hepatitis C with a DAA regimen
- History of spontaneous preterm delivery at less than 34 weeks
- Shortened cervix less than 20 mm if noted on ultrasound
- Clinical diagnosis of acute hepatitis not otherwise attributable to hepatitis C with AST or ALT ≥2.5 x ULN, evidence of decompensated cirrhosis including history of or present variceal hemorrhage, ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatocellular carcinoma, hepatorenal syndrome, or hepatopulmonary syndrome
- Any medical condition that the site investigator that participation in the study would be unsafe
- Receipt of any prohibited medication within 14 days prior to entry:
• ARVs and pharmacoenhancers: (Atazanavir, Cobicistat, Darunavir, Efavirenz, Etravirine, Lopinavir, Ritonavir)
• HMG-CoA reductase inhibitors: (Atorvastatin, Lovastatin, Simvastatin)
• Other
• Carbamazepine
• Medications containing more than 20 mcg ethinyl estradiol (e.g., combined oral contraceptives)
• Proton pump inhibitors
• Rifampin, rifapentine, rifabutin
• Nirmatrelvir/ritonavir
• St. John’s wort (hypericum perforatum)
Contact: David.Garry@stonybrookmedicine.edu & sharon.nachman@stonybrookmedicine.edu
Effect of Metformin on Vitamin B12 Levels in Pregnancy (PI: Jennifer Choi)
Recruiting pregnant patient who failed GTT in outpatient clinics.
Contact: samantha.gobioff@stonybrookmedicine.edu
ERCT on Single (oxytocin) vs Double (oxytocin + misoprostol) Uterotonic Agents to Prevent PPH (PI: James Bernasko)
Recruiting patients prior to delivery on L&D.
Contact: obgyn.sbresearch@stonybrookmedicine.edu
Perceived Agency in Decision Making for Cesarean Section (PI: Joseph Chappelle)
Recruiting post cesarean patients in the postpartum unit.
Contact: angelina.mozier@stonybrookmedicine.edu
Circulating mRNAs from placental exosomes in pregnant women with substance use exposure (PI: David Garry)
Recruiting patients in the third trimester that are on medications for OUD and a healthy control group.
Contact: Rachel.lee@stonybrookmrdicine.edu
Brain Imaging of Mothers (BIOM) (PI: James Swain)
Pregnant or up to five year postpartum including those with OUD, mental health illness, or healthy controls.
Contact: elle.eggers@stonybrookmedicine.edu.
Gynecology
Educational video to reduce anxiety before colposcopy (PI: Dorota Kowalska)
Recruiting outpatient clinics patient with abnormal PAP prior to colposcopy
Contact: Dorota.kowalska@stonybrookmedicine.edu
ERAS Educational Video to Reduce Anxiety and ED Visits (PI: Sara Kim)
Recruiting patients undergoing hysterectomy and myomectomy.
Contact: sara.kim@stonybrookmedicine.edu & megan.wood@stonybrookmedicine.edu
Gynecologic Oncology
Ovarian Cancer Organoid Study (PI: William Burke & Medhi Damaghi)
Recruiting gynecological oncology patients prior to biopsy or surgery.
Contact: mehdi.damaghi@stonybrookmedicine.edu & elayna.kirsch@stonybrookmedicine.edu
Salpingectomy vs. Salpingo-oophorectomy to reduce ovarian cancer risk in BRCA1 carriers (PI: William Burke)
Recruiting patients with BRCA1 that did not have ovarian cancer risk reduction surgery.
Contact: Catherine.Izzo@stonybrookmedicine.edu
Randomized phase 3 trial on use of immunochemotherapy (Olvi-Vec) for ovarian cancer treatment (PI: William Burke)
Patients with platinum-resistant/ refractory ovarian cancer.