Xixi Zhou, PhD
Research Assistant Professor
Stony Brook Cancer Center
Department of Pathology
Email: xixi.zhou@stonybrookmedicine.edu
Research Interests:
Toxicity and carcinogenesis mechanisms of environmental metal exposure.
Mass-spectrometry based proteomics on metal-protein interactions.
Lung carcinogenesis of particulates.
Cancer genomics analysis of environmental mutagens.
Education:
2003 – 2009: Ph.D. in Biophysics, Institute of Biophysics, Chinese Academy of Science, Beijing, China; Dissertation: Quantitative Analysis of Endogenous S-nitrosylated Proteome
1999 – 2003: B.S. in Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Positions and Employment:
2024 – Present: Senior Research Scientist, Stony Brook University Cancer Center, Stony Brook University, NY
2015 – 2024: Research Assistant Professor, Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, NM
2010 – 2015: Postdoctoral Fellow, Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, NM
Publications (selected):
Speer RM, Yu H, Zhou X, Nandi S, Alexandrov L, Guo Y, Hudson LG, Liu KJ. Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms. Toxicol Appl Pharmacol. 2024 Jan; 482:116773. doi: 10.1016/j.taap.2023.116773. Epub 2023 Nov 28. PMID: 38036231
Speer RM, Nandi SP, Cooper KL, Zhou X, Yu H, Guo Y, Hudson LG, Alexandrov LB, Liu KJ. Arsenic is a potent co-mutagen of ultraviolet light. Commun Biol. 2023 Dec 16;6(1):1273. doi: 10.1038/s42003-023-05659-4. PMID: 38104187
Qi Z, Zhou X, Dong W, Timmins GS, Pan R, Shi W, Yuan S, Zhao Y, Ji X, Liu KJ. Neuronal Zinc Transporter ZnT3 Modulates Cerebral Ischemia-Induced Blood-Brain Barrier Disruption. Aging Dis. 2023 Oct 18. doi: 10.14336/AD.2023.1011. Online ahead of print. PMID: 37962463
Erdei E, Zhou X, Shuey C, Ass'ad N, Page K, Gore B, Zhu C, Kanda D, Luo L, Sood A, Zychowski KE. Serum autoantibodies and exploratory molecular pathways in rural miners: A pilot study. J Transl Autoimmun. 2023 Mar 9;6:100197. doi: 10.1016/j.jtauto.2023.100197. eCollection 2023. PMID: 36942097
Medina S, Zhang H, Santos-Medina LV, Yee ZA, Martin KJ, Wan G, Bolt AM, Zhou X, Stýblo M, Liu KJ. Arsenite Methyltransferase Is an Important Mediator of Hematotoxicity Induced by Arsenic in Drinking Water. Water (Basel). 2023 Feb 22;15(3):448. doi: 10.3390/w15030448. Epub 2023 Jan 22. PMID: 36936034
Speer RM, Zhou X, Volk LB, Liu KJ, Hudson LG. Arsenic and cancer: Evidence and mechanisms. Adv Pharmacol. 2023;96:151-202. doi: 10.1016/bs.apha.2022.08.001. Epub 2022 Sep 27. PMID: 36858772
Cooper KL, Liu R, Zhou X*. Particulate arsenic trioxide induces higher DNA damage and reactive oxygen species than soluble arsenite in lung epithelial cells. Toxicol Appl Pharmacol. 2022 Dec 15;457:116320. doi: 10.1016/j.taap.2022.116320. Epub 2022 Nov 17. PMID: 36403797
Medina S, Zhang H, Santos-Medina LV, Wan G, Bolt AM, Zhou X, Burchiel SW, Liu KJ. Arsenic impairs the lineage commitment of hematopoietic progenitor cells through the attenuation of GATA-2 DNA binding activity. Toxicol Appl Pharmacol. 2022 Aug 9;452:116193. doi: 10.1016/j.taap.2022.116193. PMID: 35961411
Wan G, Medina S, Zhang H, Pan R, Zhou X, Bolt AM, Luo L, Burchiel SW, Liu KJ. Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34+ cells and causes decreased levels of hemoglobin. Sci Rep. 2021 Nov 11;11(1):22121. doi: 10.1038/s41598-021-01643-2. PMID: 34764389
Qi Z, Yuan S, Zhou X, Ji X, Liu KJ. Isobaric Tags for Relative and Absolute Quantitation-Based Quantitative Serum Proteomics Analysis in Ischemic Stroke Patients With Hemorrhagic Transformation. Front Cell Neurosci. 2021 Aug 25;15:710129. doi: 10.3389/fncel.2021.710129. eCollection 2021. PMID: 34512266
Medina S, Bolt AM, Zhou X, Wan G, Xu H, Lauer FT, Liu KJ, Burchiel SW. Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors. Toxicol Lett. 2021 Oct 10;350:111-120. doi: 10.1016/j.toxlet.2021.07.008. Epub 2021 Jul 15. PMID: 34274428
Pan R, Yu S, Zhang H, Timmins GS, Weaver J, Yang Y, Zhou X, Liu KJ. Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage. J Cereb Blood Flow Metab. 2021 Dec;41(12):3232-3247. doi: 10.1177/0271678X211028475. Epub 2021 Jun 29. PMID: 34187233
Zhou X, Speer RM, Volk L, Hudson LG, Liu KJ. Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins. Semin Cancer Biol. 2021 Nov;76:86-98. doi: 10.1016/j.semcancer.2021.05.009. Epub 2021 May 10. PMID: 33984503
Zhou X, Xue B, Medina S, Burchiel SW, Liu KJ. Uranium directly interacts with the DNA repair protein poly (ADP-ribose) polymerase 1. Toxicol Appl Pharmacol. 2021 Jan 1;410:115360. doi: 10.1016/j.taap.2020.115360. Epub 2020 Dec 3. PMID: 33279515
Medina S, Zhou X, Lauer FT, Zhang H, Liu KJ, Lewis J, Burchiel SW. Modulation of PARP activity by Monomethylarsonous (MMA+3) acid and uranium in mouse thymus. Toxicol Appl Pharmacol. 2021 Jan 15;411:115362. doi: 10.1016/j.taap.2020.115362. Epub 2020 Dec 3. PMID: 33279514
Zhou X, Medina S, Bolt AM, Zhang H, Wan G, Xu H, Lauer FT, Wang SC, Burchiel SW, Liu KJ. Inhibition of red blood cell development by arsenic-induced disruption of GATA-1. Sci Rep. 2020 Nov 4;10(1):19055. doi: 10.1038/s41598-020-76118-x. PMID: 33149232
Sanchez B, Zhou X, Gardiner AS, Herbert G, Lucas S, Morishita M, Wagner JG, Lewandowski R, Harkema JR, Shuey C, Campen MJ, Zychowski KE. Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation. Part Fibre Toxicol. 2020 Jul 1;17(1):29. doi: 10.1186/s12989-020-00361-3. PubMed PMID: 32611356
More complete list of publications can be found here.