Richard Lin

FACULTY


Richard Lin

 

Richard Lin
Professor

M.D., University of California, San Francisco, 1988
Biology of Phosphoinositide 3-Kinases

Basic Science Tower, T-6, Room 180
Stony Brook University
Stony Brook, NY, 11794-8661

Phone: (631) 444-1638
Email: Richard.Lin@sunysb.edu
Lab Member

 

Ya-Ping Jiang MD
Han Han (Biomedical Engineering PhD student)
Chuankai Chen (Genetics PhD student)
Giuseppe Caso, MD
Barbara Rosati, PhD
Richard Efem, MD
Research

 

 

 

 

 

 

 

 

Biology of Phosphoinositide 3-Kinases (PI3Ks)

My laboratory studies the physiological functions and pathological roles of PI3Ks. This family of lipid kinases produces the intracellular second messenger phosphatidylinositol 3,4,5-trisphosphate that regulates diverse cellular functions. We are currently investigating two research aims: 1) the role of PI3K in the development and progression of pancreatic cancer, and 2) the role of PI3K in regulating the function of cardiac ion channels. 

Abnormal upregulation of PI3K signaling is one of the most common oncogenic contributors in the development of human cancers.  We discovered that the p110α isoform of PI3K is essential for the initiation of pancreatic cancer caused by oncogenic Kras (Wu, et al. Gastroenterology 2014).  We are now investigating the role of p110α in the maintenance and progression of pancreatic cancer.

We reported that downregulation of p110α signaling due to drug inhibition or diabetic conditions changes multiple ion currents in cardiac myocytes that result in prolongation of the QT interval on the ECG (Lu et al., Science Translation al Medicine, 2012). QT prolongation in humans can increase the risk of fatal ventricular arrhythmias.  We are now studying the mechanisms by which PI3K signaling regulate cardiac ion channel function. 

 

 

 

Selected Publications

 

Dr. Lin's publications may be found at the following NCBI link:

http://www.ncbi.nlm.nih.gov/sites/myncbi/richard.lin.1/bibliography/41160594/public/?sort=date&direction=descending

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