Leon C. Moore
Professor
PhD, University of Southern California, 1976
Email: Leon.Moore@stonybrook.edu
Address: Basic Science Tower, T-5, Room 151Stony Brook University
Stony Brook, NY, 11794-8661
Research:
The Mechanism of Tear Secretion by the Lacrimal Glands
The goal of this project is to define the mechanism of ion and water transport in acinar cells in lacrimal gland. We conduct studies in mice and in isolated cells to determine the effects of ion transport inhibitors on tear fluid secretion. Using these data, we are constructed mathematical models of acinar and duct cell ion transport. These studies are important in understanding dry-eye disease.
Nonlinear Dynamics of the Renal Tubuloglomerular Feedback System
Tubuloglomerular feedback (TGF) regulates renal hemodynamics and sodium excretion. The research goal is to elucidate the function of the TGF system in healthy and hypertensive rats. Experimental studies are done to assess the regulation of cortical blood flow and to estimate TGF system parameters using time-varying spectral analysis and mathematical models. Models of epithelial ion transport are also used to study TGF signal generation in the thick ascending limb of Henles loop (TAL).
- 2006: Thomas SR, Layton AT, Layton HE, Moore LC. Kidney Modeling: Status and Perspectives. Proceedings of the IEEE, 94:740-752.
- 2006: Feng L, Siu K, Moore LC, Marsh DJ, Chon KH. A Robust Method for Detection of Linear and Nonlinear Interactions: Application to Renal Blood Flow Dynamics. Annals of Biomedical Engineering, 34:339-353.
- 2006: Layton AT, Moore LC, Layton HE. Multistability in Tubuloglomerular Feedback and Spectral Complexity in Spontaneously Hypertensive Rats. American Journal of Physiology Renal Physiology, 291:F79-F97.
- 2007: Grajdeanu PB, Moore LC, Layton HE. Effect of Tubular Inhomogeneities on Filter Properties of Thick Ascending Limb. Mathematical Biosciences, 209:564-592.
- 2008: Cordovez JM, Clausen C, Moore LC, Solomon IC. A Mathematical Model of pHi Regulation in Central CO₂-Chemoreception. Advances in Experimental Medicine and Biology, 605:306-311.
- 2008: Chon KH, Zhong Y, Moore LC, Holstein-Rathlou NH, Cupples WA. Analysis of Nonstationarity in Renal Autoregulation Mechanisms Using Time-Varying Transfer and Coherence Functions. American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 295:821-828.
- 2008: Nguyen LT, Rebecchi MJ, Moore LC, Glass PS, Brink PR, Liu L. Attenuation of Isoflurane-Induced Preconditioning and Reactive Oxygen Species Production in the Senescent Rat Heart. Anesthesia and Analgesia, 107:776-782.
- 2009: Layton AT, Moore LC, Layton HE. Multistable Dynamics Mediated by Tubuloglomerular Feedback in a Model of Coupled Nephrons. Bulletin of Mathematical Biology, 71:515-555.
- 2009: Marcano M, Yang HM, Nieves-Gonzalez A, Clausen C, Moore LC. Parameter Estimation for Models of NKCC2 Cotransporter Isoforms. American Journal of Physiology Renal Physiology, 296:F369-F381.
- 2009: Siu KL, Sung B, Cupples WA, Moore LC, Chon KH. Detection of Low-Frequency Oscillations in Renal Blood Flow. American Journal of Physiology Renal Physiology, 297:F155-F162.
- 2011: Chen J, Moore LC, Layton HE, Layton AT. A Mathematical Model of the Myogenic Response to Systolic Pressure in the Afferent Arteriole. American Journal of Physiology Renal Physiology, 300:F669-F681.
- 2011: Gao J, Sun X, Moore LC, White TW, Brink PR, Mathias RT. Lens Intracellular Hydrostatic Pressure is Generated by the Circulation of Sodium and Modulated by Gap Junction Coupling. Journal of General Physiology, 136:507-520.