Leon C. Moore

Research

The Mechanism of Tear Secretion by the Lacrimal Glands

The goal of this project is to define the mechanism of ion and water transport in acinar cells in lacrimal gland. We conduct studies in mice and in isolated cells to determine the effects of ion transport inhibitors on tear fluid secretion. Using these data, we are constructed mathematical models of acinar and duct cell ion transport. These studies are important in understanding dry-eye disease.

Nonlinear Dynamics of the Renal Tubuloglomerular Feedback System

Tubuloglomerular feedback (TGF) regulates renal hemodynamics and sodium excretion. The research goal is to elucidate the function of the TGF system in healthy and hypertensive rats. Experimental studies are done to assess the regulation of cortical blood flow and to estimate TGF system parameters using time-varying spectral analysis and mathematical models. Models of epithelial ion transport are also used to study TGF signal generation in the thick ascending limb of Henles loop (TAL).

Recent Publications

1. Thomas, SR, AT Layton, HE Layton, and LC Moore.  Kidney Modeling:  Status and Perspectives. Proc IEEE 94: 740-752, 2006.
2. Feng, L, K Siu, LC Moore, DJ Marsh, KH Chon.  A robust method for detection of linear and nonlinear interactions:  Application to renal blood flow dynamics.  Ann Biomed Eng 34: 339-353, 2006.
3. Layton AT, Moore LC, and Layton HE. Multistability in tubuloglomerular feedback and spectral complexity in spontaneously hypertensive rats. Am J Physiol Renal Physiol 291: F79-F97, 2006.
4. Grajdeanu, PB, Moore, LC and Layton HE.  Effect of tubular inhomogeneities on filter properties of thick ascending limb. Math Biosciences, 209: 564–592, 2007.
5. Cordovez, J.M., C. Clausen, L.C. Moore, and I.C. Solomon.  A mathematical model of pHi regulation in central CO2-chemoreception.  Adv. Exp. Med. Biol. 605:306-311, 2008.
6. Chon KH, Y Zhong, LC Moore, N-H Holstein-Rathlou, and WA Cupples. Analysis of nonstationarity in renal autoregulation mechanisms using time-varying transfer and coherence functions.  Am J Physiol Regulatory Integrative Comp Physiol 295:821-828, 2008.
7. Nguyen LT, Rebecchi MJ, Moore LC, Glass PS, Brink PR, and Liu L. Attenuation of isoflurane-induced preconditioning and reactive oxygen species production in the senescent rat heart. Anesthesia and analgesia 107: 776-782, 2008.
8. Layton AT, LC Moore, HE Layton.  Multistable dynamics mediated by tubuloglomerular feedback in a model of coupled nephrons.  In press:  Bull Math Biol 71: 515-555, 2009.
9. Marcano, M., H.-M. Yang, A. Nieves-Gonzalez, C. Clausen, and L.C. Moore. Parameter estimation for models of NKCC2 cotransporter isoforms. Am J Physiol Renal Physiol 296:F369-81, 2009.
10. Siu KL, Sung B, Cupples WA, Moore LC, Chon KH. Detection of low-frequency oscillations in renal blood flow. Am J Physiol Renal Physiol 297: F155–F162, 2009.
11. Chen J, Moore LC, Layton HE, Layton AT.  A Mathematical Model of the Myogenic Response to Systolic Pressure in the Afferent Arteriole.  Am J Physiol Renal Physiol 300:F669- F681, 2011.
12. Gao J, Sun X, Moore LC, White TW, Brink PR, Mathias RT. Lens intracellular hydrostatic pressure  is generated by the circulation of sodium and modulated by gap junction coupling.  J. Gen. Physiol. 136:507-520, 2011.