Wound healing pathophysiology and engineering new drugs.
Research interests include:
Fibronectin and the translational value of peptides derived from fibronectin for preventing burn injury progression and healing chronic wounds.
Representative Publications
Requirement of vascular integrin αvβ3 for angiogenesis.
PC Brooks, RAF Clark, DA Cheresh (1994). Science. 264:569-571
Cutaneous wound healing.
AJ Singer, RAF Clark (1999). N Engl J Med. 341:738-746.
Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties.
K Ghosh, Z Pan, E Guan, S Ge, Y Liu, T Nakamura, XD Ren, M Rafailovich, RAF Clark (2007).
Biomaterials. 28:671-679.
A fibronectin peptide redirects PDGF-BB/PDGFR complexes to a macropinocytosis-like pathway and augments PDGF-BB survival signals.
Zhu J, Lin, F, Brown D, and Clark RAF (2014). J Invest Dermatol. 134:921-929.
Wound repair: basic biology of tissue engineering.
RAF Clark, M Musillo, T Stransky (2020). Principles of Tissue Engineering (Fifth Edition). pp 1309-1329.
Engineered fibronectin peptide is resistant to elastase digestion, speeds healing and attenuates scarring in porcine burns.
Lin F, Prasad A, Weber-Fishkin S, Clark RA (2020). J Invest Dermatol. 140:1480-1483.
