Hong Lin, PhD

Hong Lin, PhD (aka Smith-Jones)
Head of Immunology/Flow CytometryAssistant Professor
Stony Brook University Hospital
Department of Pathology
Hospital L3
Stony Brook, NY 11794

Phone: (631) 444-2240
Email: Hong.Smith-Jones@stonybrookmedicine.edu

1990 B.Sc., Beijing University of Agriculture, Beijing, China
1998 Ph.D., Peking Union Medical College, Beijing, China.

2018 - present  Head of Immunology/Flow CytometryAssistant Professor, Stony Brook University Hospital, Stony Brook, NY 

1995 Outstanding Graduate Student Award, Peking Union Medical College. Beijing, China
2006 NIH NCI R25 Fellowship: Collaborative Program in Nutrition and Cancer Prevention
2007 NIH NCCAM Travel

1999- 2011 American Association for Cancer Research (AACR).
2002-2004 American Society of Hematology (ASH), Associate Member.
2005-2013 American Society of Hematology (ASH), Active Member
2011-present American Society for Clinical Pathology (ASCP)
2011-present International Clinical Cytometry Society (ICCS)
2013 American Association of Bioanalysts (AAB)
2014-2016 American Association of Clinical Chemistry (AACC)

Lin H, Li Y, Ni CY, Lai CN, Shen BF, et al. The Expression and Role of IL-6 and its Receptor in Peripheral Blood Mononuclear Cell of Multiple Myeloma Patient. National Medical Journal of China. 1998;78(8): 52-53

Li Y, Lai CN, Lin H, Ni CY, He YH, Shen BF. Involvement of STAT3/APRF in IL-6 signal transduction pathway. Chin J Microbiol Immunol. 1999;19(5): 422-4263. Lin H, He YH, Li Y, Lu YL, Shen BF. Rheumatoid arthritis model in rat induced by type II

Lin H, He YH, Li Y, Lu YL, Shen BF. Rheumatoid arthritis model in rat induced by type II collagen and Freund’s complete Adjuvant. Acta Laboratorium Animals Scientia Sinica. 1999;7(1): 1-6

Zhang XM, Lin H, Chen C, Chen BD. Inhibition of ubiquitin-proteasome pathway activates a caspase-3- like protease and induces Bcl-2 cleavage in human Mo7e leukaemic cells. Biochemical Journal. 1999;340:127-33PubMed - NCBI5.

Chen C, Lin H, Chen BD. Bcl-2 antibodies induce hemoglobin release by red blood cells loaded with in vitro translated Bcl-2 and its cleavage fragment. Biochemical Biophysical Research Communications. 2000; 270(3): 816-20PubMed - NCBI6.

Chen C, Lin H, Karanes C, Pettit GR, Chen BD. Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitors-induced cytochrome c-dependent apoptosis. Cancer Research. 2000;60(16): 4377-85PubMed - NCBI7.

Lin H, Zhang XM, Chen C, Chen BD. Apoptosis of Mo7e leukemia cells is associated with the cleavage of Bcl-2 into a shortened fragment that is not functional for heterodimerization with Bcl-2 and Bax. Experimental Cell Research 2000; 261(1): 180-6PubMed - NCBI8.

Lin H, Chen C, Chen BD. Resistance of bone marrow-derived macrophages to apoptosis is associated with the expression of X-linked inhibitor of apoptosis protein (XIAP) in primary cultures of bone marrow cells. Biochemical Journal 2001; 353(Pt 2): 299-306.PubMed - NCBI9.

Chu AJ, Chen BD, Lin H, Beydoun S. Antimicrobial peptide buformin I inhibits tissue factor-initiated coagulation. Archives of Biochemistry and Biophysics 2001; 392(1):3-7PubMed - NCBI

Xiong Y, Lin H, Chen BD, Peterson PL, Lee CP. Appearance of shortened Bcl-2 and Bax proteins in rat forebrain after severe experimental traumatic brain injury. Biochemical Biophysical Research Communications 2001; 286:401-5PubMed - NCBI11.

Lin H, Chen C, Li XH, Chen BD. Activation of MEK/MAPK pathway is involved in bryostatin 1-induced monocytic differentiation and up-regulation of X-linked inhibitor of apoptosis protein (XIAP). Experimental Cell Research 2002;272: 192-8PubMed - NCBI12.

Lin H, Liu XY, Subramanian B, Nakeff A, Valeriote F, Chen BD. Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 uiquitination. International Journal of Cancer 2002;97: 121-8PubMed - NCBI13.

Lin H, Subramanian B, Nakeff A, Chen BD. XK469, a novel antitumor agent, inhibits signaling by the MEK/MAPK signaling pathway. Cancer Chemotherapy and Pharmacology 2002;49: 281-6PubMed - NCBI14.

Lin H, She YH, Cassileth BR, Sirotnak FM, Cunningham-Rundles S. Mushroom beta glucan enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro. International Immunopharmcology 2004;4(1):91-99PubMed - NCBI15.

Lin H, Cheung S, Nesin M, Cassileth BR, Cunningham-Rundles S. Enhancement of umbilical cord blood cell hematopoiesis by Maitake beta-glucan is mediated by granulocyte colony-stimulating factor production. Clinical Vaccine Immunology 2007;14(1):21-7 (Epub 2006 Nov.8).PubMed - NCBI16.

Tatad F, Nesin M, Peoples J, Cheung S, Lin H, Sison C, Perlman J, Cunningham-rundles S. Cytokine expression in response to bacterial antigens in preterm and term infant cord blood monoytes. Neonatology 2008; 94:8-15(adv. e. pub 12.19.2007)PubMed - NCBI17.

Lin H, De Stanchina E, Zhou XK, She YH, Hoang D, Cheung S, Cassileth B, Cunningham-Rundles S. Maitake Beta-Glucan Enhances Umbilical Cord Blood Stem Cell Transplantation in NOD/SCID Mouse Exp.Biol.Med . 2009; 234:342-353PubMed - NCBI18.

Deng G, Lin H, Seidman A, Fornier M, D’Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth BR. A phaseI/II trial of a polysaccharide extract from Grifola frondosa (Maitake medicinal mushroom) in breast cancer patients: immunological effects. J. Cancer Res Clin. 2009; 135(9):1215-1221. Epub 2009 Mar 1PubMed - NCBI19.

Peoples J, Cheung S, Nesin M, Tatad F, Lin H, Hoang D, Perlman J, Cunningham-Rundles S. Neonatal Cord Blood Subset and Cytokine Response to Bacterial Antigens Am J. Perinatol. 2009; 26(9):647-657. Epub 2009 Apr 23.20.

Lin H., De Stanchina E, X.K Zhou, Hong F, Seidman A, Fornier M, Wesa K, Cassileth BR, Cunningham-Rundles S. Maitake Beta-Glucan Promotes Recovery of Leukocytes and Myeloid Cell Function in Peripheral Blood from Paclitaxel Hematotoxicity. Cancer Immunol Immunother. 2010; 59(6):885-897. Epub 2010 Feb 6.

Tsay J, Yang ZW, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty S, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG. Bone Loss Due To Iron Overload in aHong Lin, PhDPage 7 of 9Murine Model: Importance of Oxidative Stress. Blood 2010;116(14):2582-9 Epub 2010 June 16.PubMed - NCBI22.

Fonseca FN, Papanicolaou G, Lin H, Lau C, Kennelly EJ, Cassileth BR, Cunningham-Rundles S. Echinacea purpurea (L.) Moench Modulates Human T-cell Cytokine Response. International Immunopharmacology. 2014; 19:94-102PubMed - NCBI23.

Wesa KM, Cunningham-Rundles S, Klimek VM, Vertosick E, Coleton MI, Yeung KS, Lin H, Nimer S, Cassileth BR. Maitake Mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunology Immunotherapy 2014; 64(2): 237-47 Epub Oct 29.PubMed - NCBI24.

Espiritu MM, Lin H, Foley E, Tsang V, Rhee E, Perlman J, Cunningham-Rundles S. Omega-3 Fatty Acids Modulate Neonatal Cytokine Response to Endotoxin. J. Perinat Med 2016 44(6): 711-21PubMed-NCBI