Research Histology Core Laboratory

The Stony Brook Research Histology Core Lab (RHCL) provides clinical and basic science investigators with access to a wide range of histological procedures. The facility is managed by the Department of Pathology and offers gross processing of research tissue and cellular specimens, including fixation, paraffin embedding, sectioning and staining. Both routine hematoxylin and eosin (H&E) and advanced immunohistochemical (IHC) staining methods are offered. The Core staff and scientific director are available to assist in the development of research protocols that depend on the processing of tissue or other cellular specimens. The core is directed by Kenneth R. Shroyer, MD, PhD.

Dr. Kenneth Shroyer is a board certified surgical pathologist and cytopathologist and has been engaged in the development of advanced methods in immunohistochemistry, in situ hybridization, and the molecular analysis of tissues for more than 30 years. Additionally, he is an expert in tissue biobanking, microdissection, and in the use of tissue microarrays.

The laboratory is equipped with an embedding station, microtomes, and automated immunostainers. Additional specialized stains may be available upon request. Additional advanced services, including preparation of research tissue microarrays, laser capture microdissection, and other methods to support tissue-based research may be arranged following consultation with the Core Lab Director. Please contact the Core Lab in advance of submitting specimens to discuss methods for sample collection and tissue fixation.


Gross Prep$2 per sample$3 per sample
Gross Prep + cassette$3 per sample$4 per sample
Frozen tissue prep$2 per sample$3 per sample
Automated Processing$4 per sample$5 per sample
Embedding$2 per sample$2.50 per sample
Complex Embedding$4 per sample$5 per sample
FFPE sectioning 1st section$4 per section$5 per section
FFPE sectioning additional sections$2 per section$2.50 per section
Frozen sectioning 1st section$8 per section$9 per section
Frozen additional section$6 per section$7 per section
Decalcification$5 per sample$6 per sample
Bone FFPE 1st section$6 per section$7 per section
Bone FFPE additional section$4 per section$5 per section
H&E staining (30 or more)$3 per slide$4 per slide
H&E staining (<30)$4 per slide$5 per slide
H&E staining frozen$8 per slide$9 per slide
Masson’s Trichrome$7 per slide$8 per slide
Luxol Fast Blue$7 per slide$8 per slide
IHC Development/Optimization$460/antibody$541/antibody
IHC standard (autostainer)$35 per slide$41 per slide
IHC manual$51 per slide$60 per slide
Digital Pathology$20 per slide$24 per slide

*Immunohistochemistry/Immunofluorescence (IHC/IF) initial workup required for antibodies that are not already on line in the lab and for any antibodies that have not been previously optimized for immunohistochemical staining on FFPE sections.

Internal Stony Brook Users: Register with iLab
1. To place orders, request that your Principal Investigator log in to E-RAS and provide you with iLab User or iLab Approver authorization.
2. Click
here and select “Login” in the upper right-hand corner.

3. Follow the prompts to click on an additional Login link then enter your Stony Brook Net ID and password (to request a Net ID and password, log onto SOLAR and select "NetID Maintenance" under the "Security and Personal Data" link).

External Stony Brook Users: Sign up for iLab Account

1. Complete the account sign-up form here.
You will receive an email with login account information and basic instructions to get started using the system once your account has been approved.

The Histology Core Lab appreciates acknowledgement of services provided in publications that may arise from your research. Sample wording: We would like to acknowledge the technical support provided by the Research Histology Core Laboratory, Department of Pathology, Stony Brook Medicine.