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Jun Chung, PhD

Jun Chung, PhD
Associate Professor, Department of Pathology

Basic Sciences Tower, Level 9

Stony Brook Medicine

Stony Brook, NY 11794-8691
 

Tel: (631) 444-3000
Fax: (631) 444-3424
Email: Jun.Chung@stonybrookmedicine.edu 

Research Interests: Dr. Chung’s research is focused on understanding the mechanism of cancer invasion and metastasis. Specific emphasis is on the molecular signature that makes Triple Negative Breast Cancer (TNBC) aggressive so that TNBC specific biomarker and therapeutic intervention can be developed. Dr. Chung's laboratory is particularly interested in the molecule named "integrin beta4 (ITG b4)" whose expression correlates significantly with TNBC, but there is no targeted therapy against this molecule. Dr. Chung's laboratory have made substantive contributions in the area of ITG b4 signaling in breast cancer invasion and metastasis. The current focus is on the development of targeted therapies and biomarkers in TNBC model by targeting ITG b4 signaling. Multiple projects in these subjects are currently available for Ph.D. thesis and post-doctoral training.

Education:

Institution and LocationDegreeYearField of Study
Yonsei University, Seoul, KoreaB.S.1991Biochemistry
University of Minnesota, Minneapolis, MNM.S.1994Genetics and Cell Biology
Washington University School of Medicine, St. Louis, MOPh.D.1999Molecular Cell Biology

Positions and Employment:

1994-1999Research Assistant, Molecular Cell Biology Program, Washington University School of Medicine, St. Louis, MO
2000-2005Research Associate, Department of Pathology, Harvard Medical School, Boston, MA
2005Postdoc, Department of Pathology, Harvard Medical School, Boston, MA
2007-presentConsultant, Tumor Biology, Biogen IDEC, Inc., San Diego, CA
2005-2013Member, Graduate Faculty (Biochemistry & Molecular Biology), Louisiana State University, Shreveport, LA
2006-2013Member, Breast Cancer Focus Group, Louisiana State University Health Sciences Center, Shreveport, LA
2005-2013Member, Invasion and Metastasis Group, Louisiana State University Health Sciences Center, Shreveport, LA
2005-2013Member, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA
2005-2011Assistant Professor, Department of Biochemistry, Louisiana State University Health Sciences Center, Shreveport, LA
2011-2013Associate Professor w/tenure, Dept. of Biochemistry, Louisiana State University Health Sciences Center, Shreveport, LA
2012-2013Director of Breast Cancer Focus Group in Feist Weiler Cancer Center, Shreveport, LA
2013-2015Oklahoma TSET Cancer Research Scholar, Stephen Cancer Center, University of Oklahoma Health Sciences Center
2013-2015Associate Professor, Department of Physiology, University of Oklahoma Health Sciences Center
2015-presentAssociate Professor, Department of Pathology, Stony Brook Medicine

Selected Publications:

Chung J, Gao AG, Frazier WA.  Thrombospondin acts via integrin associated protein to activate the platelet integrin aIIbb3. J Biol Chem 1997;272:14740-46
Chung J, Wang XQ, Lindberg FP, Frazier WA. Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in a2b1-mediated platelet activation. Blood 1999;94:642-48
Green JM, Zhelesnyak A, Chung J, Lindberg FP, Sarfati M, Frazier WA, Brown EJ. Role of Cholesterol in formation and function of a signaling complex involving avb3, integrin associated protein (CD47), and heterotrimeric G proteins. J Cell Biol 1999 146: 673-82
Bachelder RE, Crago A, Chung J, Wendt M, Shaw L, Robinson G, and Mercurio AM. VEGF is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res 2001, 61: 5736-40
Chung J, Bachelder RE, Lipscomb E, Shaw LM, and Mercurio AM. Integrin (a6b4) regulation of eIF-4E  activity and VEGF translation. J Cell Biol 2002, 158:165-174
Mercurio AM, Bachelder RE, Bates, RC and Chung J. Autocrine Signaling in Carcinoma: VEGF and the a6b4 Integrin. Semin Cancer Biol 2004, 14: 115-122
Chung J* and Mercurio AM. Contribution of the a6 Integrins to Breast Carcinoma Cell Survival and Progression. Mol Cells 2004, 17 (2): 203-209
Chung J, Yoon S, Datta K, Bachelder RE and Mercurio AM. Hypoxia induced VEGF transcription and survival is dependent on a6 integrin expression in breast carcinoma cells. Cancer Res 2004, 64: 4711-4716
Chung J, Yoon S, Lipscomb E and Mercurio AM. Met and the a6b4 integrin can function independently to promote carcinoma invasion. J Biol Chem 2004, 279: 32287-32293
Lui L, Chen L, Chung J and Huang S. Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene 2008 May, 27:4998-5010
Kim HI, Huang H, Cheepala S, Huang S and Chung J*. Curcumin inhibition of integrin (a6b4) dependent breast cancer cell motility and invasion. Cancer Prevention Research 2008, Oct, 1 (5):385-391
Kim TH, Kim HI, Soung YH, Shaw LM and Chung J*.Integrin (a6b4) Signal through Src to increase a Metastasis Promoting Factor, S100A4 Expression: Implications to Cancer Cell Invasion. Molecular Cancer Research 2009, Oct 6 7(10)
Korneeva NL, Soung YH, Kim HI, Cheng B, Giordano A, Rhoads RE, Gram H, and Chung J*. Mnk kinase regulates integrin (a6b4) dependent translation initiation via alteration of eIF4F integrity Molecular Cancer Research 2010 Oct 21 Vol 8, Issue 12: 1571-1578 (selected as a highlighted article by editors)
Soung YH and Chung J*. Curcumin inhibition of functional interaction between integrin a6b4 and epidermal growth factor receptor. Molecular Cancer Therapeutics 2011 May;10(5):883-91
Soung YH, Pruitt K, Chung J*. Epigenetic silencing of ARRDC3 expression in basal-like breast cancer cells. Scientific Reports. 2014 Jan 24: 4:3846
Chen L, Xu B, Liu L, Liu C, Luo Y, Chen X, Barzegar M, Chung J, and Huang S. Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. Oncotarget 2015 Jan 23: 1-15
Soung YH, Coleman D, Cardelli JA, and Chung J*. Curcumin inhibits DHHC3 activity and palmitoylation of integrin beta4 in breast cancer cells. Plos One 2015 May 4: 10 (5): e0125399
Soung YH, Nguyen T, Cao H, Lee J and Chung J*. Emerging roles of exosomes in cancer invasion and metastasis. BMB Reports 2015 Nov 20 (Epub ahead of print)

*Corresponding author