Jiang Chen, MD

Jiang Chen, MDan image is here
Associate Professor
Department of Dermatology
Basic Sciences Tower, Level 7, Rm 156
Stony Brook Medicine
Stony Brook, NY 11794-8691  

Office:  (631) 444-3199
Lab:  (631) 444-6484
Fax:  (631) 444-3424
Email: Jiang.Chen@stonybrookmedicine.edu      

Research Summary:   
Dr. Chen’s laboratory is interested in using the skin and hair follicles as model systems to understand signaling pathways involved in epithelial development, homeostasis and cancer.  Recently, Dr. Chen’s laboratory discovered that tissue-specific PCP effector genes are essential for the formation of the primary cilium, which is indispensible for processing hedgehog (Hh) signals during follicular keratinocyte differentiation.  The main focus of Dr. Chen‘s current research is to use genetically engineered mutant mouse models to determine how PCP signaling and primary cilia regulate keratinocyte proliferation, migration, differentiation during skin development and skin cancer formation.  Knowledge gained from these studies will provide important insights into hair loss and the development of skin cancers.  Dr. Chen’s laboratory is also involved in the development of keratinocyte stem cells-based therapeutic strategies for genetic skin disorders caused by keratin mutations, such as epidermolytic hyperkeratosis (EHK) and pachyonychia congenita (PC).

Education:  
Institution and Location Degree Year
Henan Medical University, China M.D. 1995
University of Heidelberg M.D. (Ph.D. thesis)  2001

Positions and Employment:
1995-96 Research Associate, Beijing Medical University
1999-01 Research Scientist, University of Tuebingen 
2001-02 Research Associate, University of Heidelberg
2002-07 Postdoctoral Fellow, Baylor College of Medicine
2007-10 Research Instructor, University of Colorado Denver
2010-12 Assistant Professor, University of Colorado Anschutz Medical Campus
2011-12 Member, University of Colorado Comprehensive Cancer Center
2011-12 Graduate Faculty, Graduate Program in Cell Biology, Stem Cells, and Development
2012-present Associate Professor, Stony Brook University, NY
2013 - Member, Graduate Program in Molecular and Cellular Biology
2014 - Member, Graduate Program in Genetics

Honors:
2005 Timberline Symposium Travel Stipend
2007 North American Hair Research Society Travel Scholarships
2007 North American Hair Research Society Mentorship Award
2009 Dermatology Foundation Research Career Development Award
2015 Marvin Kuschner Excellence in Research Award, Department of Pathology, Stony Brook Medicine

Professional Memberships:

International Consortium of Pachyonychia Congenita (IPCC)
Society of Investigative Dermatology (SID)
2012 Chinese Society of Dermatology Foreign Youth Member (inaugural international member)

Peer - Reviewed Publications:

Song Y, Chen X, Zhao Q, Stanic V, Lin Z, Yang S, Chen T, Chen J*, Yang Y* (2021). Hair loss caused by gain-of-function mutant TRPV3 is associated with premature differentiation of follicular keratinocytes. J Invest Dermatol (in press).* Corresponding authors. 

Rostaher A, Bettenay S, Specht L, Silva KA, Bechtold L, Chen J, Majzoub M, Mueller RS, Sundberg JP (2021). Hair follicle dystrophy in a litter of domestic cats resembling lanceolate hair mutant mice. Vet Dermatol. 32:74-e14. 

Liu Y, Chen X, Choi YJ, Yang N, Song Z, Snedecor ER, Liang W, Leung EL, Zhang L, Qin C, Chen J (2020). GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression and mesenchymal cell migration. FASEB J  34:4918-4933. 

Hu Y, Song Z, Chen J, Caulin C (2020). Overexpression of MYB in the skin induces alopecia and epidermal hyperplasia. J Invest Dermatol 140:1204-1213.  

Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J (2019). RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis. PLOS Genet 15:e1007914.

Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. 2017 36:4997-5005.

Toriyama, M. Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelley MR, Kim S, Park TJ, Braun D, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco  B, Al-lami HA, Yeung Y, Choi YJ, University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB (2016). The ciliopathy-associated CPLANE proteins direct basal body recruitment of IFT machinery. Nat Genet 48:648-656.

Liu Y, Snedecor ER, Choi YJ, Yang N, Zhang X, Xu Y, Han Y, Jones EC, Shroyer KR, Clark RA, Zhang L, Qin C and Chen J (2016). Gorab is required for dermal condensate cells to respond to hedgehog signals during hair follicle morphogenesis. J Investig Dermatol 136:378-86.

Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C and Chen J (2016). Correction of hair shaft defects through allele-specific silencing of mutant Krt75. J Invest Dermatol 136:45-51.

Yang N, Li L, Thibaut Eguether, Sundberg JP, Pazour GJ and Chen J (2015). Intraflagellar transport 27 (IFT27) is essential for Hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development 142:2194-202.

Snedecor ER, Sung C, Moncayo A, Rothstein BE, Mockler DC, Tonnesen MG, Jones EC, Fujita M, Clark RA, Shroyer KR and Chen J (2015). Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression. J Invest Dermatol 135:1456-8.

Chen J, Laclef C, Moncayo A, Yang N, Li L, Takemaru KI, Paus R, Schneider-Maunoury S and Clark RA (2015). Ciliopathy gene Rpgrip1l is essential for hair follicle development. J Invest Dermatol 135:701-9.

Dai D, Li L, Guevara E, Zeng H, Huebner A, Claypool D, Liu A and Chen J (2013). Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ 20:130-8.

Chen J and Roop DR (2012). Mimicking hair disorders by genetic manipulation of organ cultured human hair follicles. J Invest Dermatol 132:2312-4.

Li Li, Zeng Y, Fang K, Xiao Y, Jin H, Ray H and Chen J (2012). Anetodermic pilomatricoma: Molecular characteristics and trauma in the development of its bullous appearance. Am J Dermatopathol 34:e41-5.

Chen J and Chuong CM (2012). Patterning skin by planar cell polarity: the multi-talented hair designer. Exp Dermatol 21:81-5.

Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Roop DR, Leavitt AD and Li Y (2011). Keratin 6 marks bipotential mammary progenitor cells that can give rise to unique tumors resembling human normal-like breast cancer. Oncogene 30:4399-409.

Bilousova G, Chen J and  Roop DR (2011). Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage. J Investig Dermatol 131:857-64 (Cover story with commentary).

Dai D, Zhu H, Wlodarczyk B, Zhang L, Li AG, Finnell RH, Roop DR and Chen J (2011). Fuz is a PCP effector gene that controls the morphogenesis and differentiation of hair follicles. J Invest Dermatol. 131:302-10.

Li F, Huang Q, Chen J, Peng Y, Roop DR, Bedford JS, Li CY (2010). Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal. 23:ra13 (Cover story).

Chen J, Roop DR (2008). Genetically engineered mouse models for skin research: taking the next step. J Dermatol Sci. 52:1-12 (Review).

Chen J, Jaeger K, Den Z, Koch PJ, Sundberg JP and Roop DR (2008). Mice expressing a mutant Krt75 (K6hf) allele develope hair and nail defects resembling pachyonychia congenita. J Invest Dermatol. 128:270-9 (Cover story).

Chen J, Roop DR (2005) Mouse models in preclinical studies for pachyonychia congenita. J Invest Dermatol Symp Proc. 10:37-46 (Review).

Chen J, Kasper M, Heck T, Nakagawa K, Humpert PM, Bai L, Wu G, Zhang Y, Luther T, Andrassy M, Schiekofer S, Hamann A, Morcos M, Chen B, Stern DM, Nawroth PP, Bierhaus A (2005). Tissue factor as a link between wounding and tissue repair. Diabetes. 54:2143-54. 

Chen J, Bierhaus A, Schiekofer S, Andrassy M, Chen B, Stern D, Nawroth P (2001). Tissue factor--a receptor involved in the control of cellular properties, including angiogenesis. Thromb Haemost. 86:334-45 (Review).

Abe K, Shoji M, Chen J, Bierhaus A, Danave I, Micko C, Casper K, Dillehay D, Nawroth P, Rickles F (1999). Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. Proc Natl Acad Sci U S A. 96:8663-8.

Zhang Y, Weiler-Guettler H, Chen J, Wilhelm O, Deng Y, Qiu F, Nakagawa K, Klevesath M, Wilhelm S, Bohrer H, Nakagawa M, Graeff H, Martin E, Stern D, Rosenberg R, Ziegler R, Nawroth P (1998). Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity. J Clin Invest 101:1301-9.