Ke Jian “Jim” Liu, PhD
Associate Director for Basic Science
Stony Brook Cancer Center
Professor
Department of Pathology
MART Level 7, Room 0830
Lauterbur Drive
Stony Brook, NY 11794-7263
Phone: (631) 216-2823
e-mail: kejian.liu@stonybrookmedicine.edu
Dr. “Jim” Liu is a well-established investigator with primary research interest in investigating the molecular mechanisms of metal toxicity and carcinogenesis, particularly arsenic co-carcinogenesis in enhancing UV-induced DNA damage, inhibition of DNA repair, and formation of mutational signatures assessed by whole genome sequencing. His research interests also include developing technology and approaches to study oxidative stress in disease development and alteration of tissue oxygenation, such as hypoxia is tumor tissue. A particular strength of their research is the utilization of multidisciplinary approaches, using techniques ranging from chemical to biochemical to biophysical, and from molecular and cellular level to animal models, to answer the specific biological questions. Their research efforts have been continuously supported by numerous NIH grants since 1997, leading to the publications of over 240 peer-reviewed papers.
During his long research career, over 30 graduate students, postdoctoral fellows, and junior research faculty have been trained and mentored in his lab, with many of them now being independent PIs in academic institutions and government agencies. Most notably, from 2004 to 2018, he served as the associate director, and then director/PI, of the NIH-funded Center of Biomedical Research Excellent (COBRE) program (P30GM103400). A major goal of the program is to train and mentor junior faculty so that they can successfully compete for NIH R01 funding. He also had served as the Associate Dean for Research at the University of New Mexico College of Pharmacy and was responsible for developing research programs and mentoring faculty. He is passionate about training next generation of researchers and enthusiastic about helping junior investigators in developing their academic career.
| Education: | |||
| Institution and Location | Degree | Year | Field of Study |
| Peking University, Beijing, China | BSc | 1982 | Chemistry |
| The University of Leeds, England | PhD | 1988 | Radiation Biochemistry |
Postdoctoral Training |
|
| 1988-1989 |
Biophysical Chemistry, Radiation Laboratory, University of Notre Dame, Indiana |
| 1990-1993 | Biophysics/Physiology, Department of Biophysics & Physiology, University of Illinois at Urbana-Champaign, Illinois |
Major Research Interests |
| Molecular mechanism of environmental arsenic and chromium-induced toxicology and carcinogenesis |
| Interaction of metals with zinc-containing proteins, and zinc supplement as a chemoprevention strategy for reducing arsenic toxicity and carcinogenesis |
| Arsenic co-carcinogenesis in enhancing UV-induced DNA damage, inhibition of DNA repair, and formation of mutational signatures assessed by whole genome sequencing |
| Molecular mechanism of brain injury and neuroprotection in stroke |
| In vivo imaging of oxidative stress and tissue oxygenation |
| Current and Previous Appointments | |
| 2022-present | Professor, Department of Pathology, Stony Brook Renaissance School of Medicine, Stony Brook, NY |
| 2022-present | Associate Director for Basic Research, Stony Brook Cancer Center, Stony Brook, NY. |
| 2017-2022 | Distinguished Professor, University of New Mexico, Albuquerque, NM |
| 2013-2022 | Associate Dean for Research, Coll. of Pharmacy, University of New Mexico, Albuquerque, NM |
| 2009-2017 | Director, Brain Imaging Center, University of New Mexico, Albuquerque, NM |
| 2008-2013 | Assistant Dean for Research, Coll. of Pharmacy, University of New Mexico, Albuquerque, NM |
| 2006-2022 | Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM |
| 2004-2009 | Associate Director, Brain Imaging Center, University of New Mexico, Albuquerque, NM |
| 2003-present | Adjunct Professor, Dept. of Neurology, Univ. of New Mexico, Albuquerque, NM |
| 2002-2006 | Associate Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM |
| 1999-2002 | Assistant Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM |
| 1993-1999 | Research Assistant Professor and Lab Manager, EPR Center for the Study of Viable Biological Systems, Department of Radiology, Dartmouth Medical School, NH |
