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Maoxin Wu, MD, PhD

Maoxin Wu, MD, PhDan image is here
Clinical Professor, Department of Pathology
Chief of Cytopathology

Director of Fine Needle Aspiration (FNA) and Core Biopsy Services 
University Hospital Level 2
Stony Brook Medicine
Stony Brook, NY 11794-7025

Tel: (631) 444-3000
Fax: (631) 444-3424
Email: Maoxin.Wu@stonybrookmedicine.edu

CLINICAL PRACTICE: Board Certified in Anatomic and Clinical Pathology and Cytopathology. Subspecialties in Cytopathology with experties in performance and interpretation of Fine Needle Aspiration Biopsy (FNAB) and Core Biopsy with or without ultrasound guidance; and Surgical Pathology with extensive experience in Head/Neck and Pulmonary Pathology. Strong interest in early Cancer detection and predictive tumor  marker exploration in cytology samples.

RESEARCH SUMMARY:

  • Advanced therapeutic monitoring of head and neck squamous cell carcinoma via FNA and molecular studies
  • Study of lung lesions: correlation between cytomorphology and molecular markers in various types of lung lesions including benign, hyperplasia, atypical adenomatous hyperplasia and carcinomas
  • miRNA detection and analysis in lung cancers
  • Applying molecular studies in routine cytology practice
  • Cytological and molecular classification of lung cancers
  • Pilot Study to Evaluate miRNA in FNA materials from archived thyroid lesions
  • Current Research - Detection of Metastases in Lymph Nodes Using Quantitative-Ultrasound
EDUCATION: 
Institution/ LocationDegreeYear(s)
Shanxi Medical College (P.R. China)M.D.1979-1984
University of Illinois at Urbana-ChampaignM.S.1988-1991
University of Illinois at Urbana-ChampaignPh.D1991-1995

POSTDOCTORAL TRAINING: 

Year(s)Institution/ Location
1984-1987Medical Resident, The First People's Hospital of Luliang District, Shanxi Province, The People's Republic of China
1995-1996Resident in Pathology, St. John's Mercy Medical Center, St. Louis, Missouri
1996-1997
Resident in Pathology, Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY
1997-1998
Chief Resident in Pathology, Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY
1998-1999Resident in Pathology, Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY
1999-2000Fellow in Cytopathology, Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY
2007-2008
Advanced Sonographic Procedures, Western Suffolk BOCES School of Diagnostic Medical Sonography, NY

POSITIONS HELD::

Year(s)Institution/ Location
1987-1990Visiting Scholar & Research Assistant, (EPR) Center, College of Medicine, University of Illinois at Urbana-Champaign
1991-1995Research & Teaching Assistant, Department of Pathology, College of Medicine, University of Illinois at Urbana-Champaign
2005-2014
Assistant Professor, Dept. of Otolaryngology and head and neck surgery, Mount Sinai School of Medicine, NY
2000-2006
Assistant Professor, Department of Pathology, Mount Sinai School of Medicine, NY
2006-2011Associate Professor, Department of Pathology, Mount Sinai School of Medicine, NY
2011-2014Clinical Professor, Department of Pathology, Mount Sinai School of Medicine, NY
2014-presentAdjunct Clinical Professor, Department of Pathology, Mount Sinai School of Medicine, NY
2014-presentClinical Professor, Department of Pathology, Stony Brook Medicine, NY

RECENT PUBLICATIONS:

H. Hu and M. Wu  “Nonlocal effects of chemical substances on the brain produced through quantum entanglement”
Progress in Physics 20-26 (3), 2006.

H. Hu and M. Wu  “ Photon induced non-local effects of general anesthetics on the brain”
Cogprints:ID4783, Neuroquantology March Special Issue,  2006.

M. Wu , D. E. Burstein, S. Yuan , L.A. Nurse, A. H. Szporn, D. Zhang, E. Genden “A comparative study of 200 fine needle aspiration biopsies performed by clinicians and  Cytopathologists” Laryngoscope.  Jul; 116(7):1212-5, 2006.

M. T. Idrees, T. Kalir, M. Wu, D. E. Burstein “Immunohistochemical detection of XIAP in cervical squamous intraepithelial neoplasia and carcinoma” Ann Diagn Pathol. Epub 2007 Oct 18;  Apr;12(2):85-9, 2008.

A. H. Szporn, S Yuan, M. Wu, D.E. Burstein “Cellular Swirls in fine-Needle Aspirates of Papillary thyroid Carcinoma: A New Diagnostic Criterion” Modern Pathology (19) 1470-1473, 2006.

M. Wu, Y. X. Sun, G. Desman, L. Gan, J. Gil and D. E. Burstein “XIAP Immunostaining distinguishes malignant mesothelioma from benign mesothelial hyperplasia” Am J Clin Pathol. Nov; 128(5):783-7, 2007.

M. Wu, L. Orta, J. Gil, L. Gan, A. Hu, D. E. Burstein “Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalvelolar carcinoma and well-differentiated adenocarcinoma”
Modern Pathology 21, 553-558, 2008.  

L. Zhang, Z. Chen, M. Fukuma, L. Y. Lee, M. Wu “Prognostic significance of race and tumor size in carcinosarcoma of gallbladder: a meta-analysis of 68 cases” International Journal of Clinical and Experimental Pathology,  Int J Clin Exp Pathol 1, 75-83, 2008.

D. G. Nicastri , M. Wu , J. Yun , S. J. Swanson “Evaluation of efficacy of an ultrasonic scalpel for pulmonary vascular ligation in an animal model.” J  Thorac Cardiovasc Surg.  Jul ;134 (1):160-4, 2007.

M. Wu, M. Padilla, J, Moline, R. Herbert, D. Mendelson, V. Litle, W. Travis, J. Gil “Brondiolitis and Peribronchiolar Interstitial disease in 4 Patients Exposed to World Trade Center smoke and Dust”
Archives of Pathology & Laboratory Medicine Vol 132, 289, Feb 2008. 

V. Shtilbans, M.Wu and D. E. Burstein "Current Overview of the Role of Akt in Cancer Studies via Applied Immunohistochemistry" Annals of Diagnostic Pathology 12 (2008) 153-160. Review.

V.K Gupta, A. Feber , L. Xi , A. Pennathur, M. Wu, J. D. Luketich, T. E. Godfrey "Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma”.
Clin Cancer Res. Dec 1;14 (23):7804-12, 2008. 

D. E. Burstein, M. T. Idrees , L. Gan, M. Wu, T. Kalir  “Immunohistochemical detection of the X-linked inhibitor of apoptosis protein (XIAP) in cervical squamous intraepithelial neoplasia and squamous carcinoma”
Ann Diagn Pathol. Epub 2007 Oct 18. Apr;12(2):85-9, 2008. 

M. Wu, A. Kafanas, L. Gan, D. S. Kohtz, L. Zhang, E. Genden, D. E. Burstein "Feasibility of Immunocytochemical Detection of XIAP, p-histone H1 and p63 in FNA Samples from HNSCC" Diagn Cytopathol. Oct 1;36(11):797-800, 2008.

B. L. Hoch , M. Wu , M. Lewis, L. Gan, D.E Burstein “An immunohistochemical study of   XIAP expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma”
J Oral Pathol Med. Epub 2008 Jul 29. Nov;37(10):634-8, 2008.

J. Wu, W. Zhang, B. Xie, M. Wu, X. Tong, J. Kalpoe and D. Zhang "Detection and Toxin Typing of Clostridium perfringens in Formalin-Fixed, Paraffin-Embedded Tissue Samples by PCR".
J.of Clinical Microbiology, March; 807–810 Vol. 47, No. 3, 2009. 

M. Wu , K. Sun, J. Gil, L.Gan, D. E. Burstein “Immunohistochemical detection of p63 and XIAP in thymic hyperplasia and thymomas”Am J Clin Pathol. May; 131(5):689-93, 2009. 

L. Xi , A. Feber, V. Gupta, M. Wu, A.D Bergemann, R. J. Landreneau RJ, V. R. Litle, A. Pennathur, J.D. Luketich, T. E. Godfrey  “Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer”
Nucleic Acids Res. Epub 2008 Oct 16. Nov;36 (20):6535-47, 2008.

A. Feber , L. Xi, J. D. Luketich, A. Pennathur, R. J. Landreneau, M. Wu, S. J. Swanson, T. E. Godfrey, V. R. Litle  “MicroRNA expression profiles of esophageal cancer”J Thorac Cardiovasc Surg.  Epub 2007 Dec 26. Feb;135 (2):255-60, 2008.

 J. Wu, W. Zhang , B. Xie , M. Wu , X. Tong, J. Kalpoe, D. Zhang “Detection and toxin typing of Clostridium perfringens in formalin-fixed, paraffin-embedded tissue samples by PCR”
J Clin Microbiol. Epub 2008 Dec 24; Mar;47(3):807-10, 2009. 

V. A. Fitzhugh, S. A. Kim, A. Borcich, H. Zhu, M. Wu, A. H. Szporn, H. Chen  “Metastatic hepatocellular carcinoma presenting as a pancreatic mass by computed tomography scan and mimicking a primary neuroendocrine tumor: A potential pitfall in aspiration cytology”
Diagn Cytopathol. Dec;37(12):915-9, 2009.

V. A. Fitzhugh, K. P. Maniar, V. V. Gurudutt , M. Rivera, H. Chen, Wu M. “Fine-needle aspiration biopsy of granular cell tumor of the tongue: a technique for the aspiration of oral lesions”.
Diagn Cytopathol.  Nov;37(11):839-42, 2009.

M. Wu , R. E. Gordon, R. Herbert, M. Padilla, J. Moline, D. Mendialson, V. E. Litle, W. E. Travis, J. Gil “Lung Disease in World Trade Center Responders Exposed to Dust and Smoke - Carbon nanotubes found in the lungs of WTC patients and dust samples”.
Environ Health Perspect doi:10.1289/ehp.0901159, 2009; 118(4) April, 2010.

V. Shtilbans, M. Wu, D. E. Burstein "Evaluation of Apoptosis in Cytologic Specimens" Diagn. Cytopathol., Mar 12. Epub, 2010.

M. Wu,  M. Idrees, Zhengbin Zhang, Eric Genden, David E Burstein “Papanicolaou Stain may Not be Necessary in Majority of Head and Neck FNAs-Evidence from a Correlation Study between Diff Quik-based Onsite Diagnosis and Final Diagnosis in 287 Head and Neck FNAs” Diagn. Cytopathol. 2010 Mar 18, 2010

M. Wu "A Comparative Study of 200 Head and Neck FNAs Performed by a Cytopathologist with or without Ultrasound Guidance-Evidence for improved diagnostic value with ultrasound guidance"
Diagn Cytopathol., 2010 Oct 14. [Epub ahead of print]PMID: 20949470.

Jang DW, Khan A, Genden EM, Wu M “Syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy.” Diagn Cytopathol. 2011 Aug;39(8):603-5. doi: 10.1002/dc.21503. Epub 2010 Nov 2.

Urrego PA, Smethurst M, Fowkes M, Peterson B, Strauchen J, Wu M, Szporn AH, Chen H. "Primary CNS plasmablastic lymphoma: Report of a case with CSF cytology, flow cytometry, radiology, histological correlation, and review of the literature".
Diagn Cytopathol. 2010 Oct 14.

Maoxin Wu, Hua Chen, XiaoYong Zheng, David Burstein "Testing a Scoring System for Predicting Lymph Node Malignancy in Ultrasound Guided FNA Practice" Diagn Cytopathol. 2011 Jun 10. doi: 10.1002/dc.21745. [Epub ahead of print]

Feber A, Xi L, Pennathur A, Gooding WE, Bandla S, Wu M, Luketich JD, Godfrey TE, Litle VR. "MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma."
Ann Thorac Surg. 2011 May; 91(5):1523-30. Epub 2011 Mar 21.

Zhonghua Li, Jing-Jing Yang, Maoxin Wu "Collision tumor of primary merkel cell carcinoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, diagnosed on ultrasound-guided fine-needle aspiration biopsy: A unique case report and review of literature."
Diagn Cytopathol. 2014 Mar 8. doi: 10.1002/dc.23127. 2014.

Dianne Grunes, MD, David Yankelevitz, MD, Arnold H. Szporn, MD, Mary Beth Beasley, David Y. Zhang, MD, PhD,  Ye Fei, PhD, Qiusheng Si, MD, PhD, David E. Burstein, MD, Fadi Salem, MD, Zesong Zhang, MD, MS, MD, Maoxin Wu, MD, PhD.
Fine Needle Aspiration of Small Pulmonary Nodules Yields Reliable Material for Molecular Analysis of Adenocarcinomas,
Accepted with minor revision on Journal of the American Society of Cytopathology 2014.