Wang Lab: Publications

Wang, HY., and Malbon, C.C. (2011)
      Probing the Physical Nature and Composition of Signalsomes J. Mol. Signal. 6: 1-10.
Wang, HY., and Malbon, C.C. (2011)
      Dishevelled C-terminus: Structural Insights Acta Physiolog. 195, Mar 29. [Epub ahead of print]
Goa, S., Wang, HY., and Malbon, C.C. (2011)
      AKAP5 and AKAP12 Form Homo-oligomers. J. Mol. Signaling 6 (1): 3.
Ma, L., Wang, Y., Malbon, C.C., and Wang, HY. (2010)
      Dishevelled-3 C-terminal His Single Amino Acid Repeats are Obligate for Wnt5a Activation of Non-canonical Signaling  J. Mol. Signal. 5: 19-29.
Yokoyama, N., Golebiewska, U., Wang, HY., and Malbon, C.C. (2010)
      Wnt-dependent Assembly of Supermolecular Dishevelled 3-based Complexes      J. Cell Science 123: 3693-3702. (see “In This Issue” for highlights)
Tao, J., Wang, HY., and Malbon, C. (2010)
      AKAR2-AKAP12 Fusion Protein “Biosenses” Dynamic Phosphorylation and Localization of a GPCR-based Scaffold  J. Mol. Signaling 5: 17-39.
Okoye, U.C. and Wang, HY. (2008)
      Wnt and Frizzled RNA expression in human Mesenchymal and embryonic (H7) stem cells. J. Mol. Signal. 3:16-25.
Lee, Y.-N., Gao, Y. and Wang, HY. (2008)
      Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.  Cell. Signal. 20:443-452.
Ma, L., and Wang, HY. (2007)
      Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non- canonical pathway.  J. Biol. Chem. 282:28980-28990.
Gao, Y. and Wang, HY. (2007)
      Inositol pentakisphosphate mediates Wnt/b-catenin signaling. J. Biol. Chem. 282:26490-26502.
Ma L., Wang HY. (2006)
      Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway. J Biol Chem. 281:30990-1001.
Gao, Y. and Wang, HY. (2006)
      Casein kinase 2 is activated and essential for Wnt/b-catenin signaling.  J. Biol. Chem. 281:18394-18400.
Gavi, S., Shumay, E., Wang, HY, and Malbon, C.C. (2006)
      G-Protein-Coupled Receptors as Substrates for Tyrosine Kinases. Trends Endocrinol. Metabo. 17: 48-54.
Wang, HY., Liu, T. and Malbon, C.C. (2006)
      Structure-Function Analysis of Frizzleds. Cell Signal. 18: 934-41
Wang, HY., Tao, J., Shumay, E., and Malbon, C. C. (2006)
      G-Protein-coupled receptor-associated A-Kinase anchoring proteins:AKAP79 and AKAP250 (gravin). Eur. J. Cell Biol. 85: 643-50
Malbon, C.C. and Wang, HY. (2005)
      Dishevelled: A mobile scaffold catalyzing development. Curr. Top. Dev. Biol. 72:153-166
Yin, D., Gavi, S., Shumay, E., Duell, K., Konopka, J.B. Malbon, C.C. and Wang, HY. (2005)
       Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells. Biochem. Biophys. Res. Commun. 329:281-7.
Gavi, S., Yin, D., Shumay, E., Wang, HY, and Malbon, C.C. (2005)
       The cytoplasmic C-terminus of the b2 adrenergic receptor harboring an SH2 domain and Akt phosphorylation sites is sufficient to confer insulin-stimulated counterregulation to the b1-adrenergic receptor  Endocrinology. 146:450-7
Lee, YN., Malbon, C.C. and Wang, NY. (2004)
      Ga13 Signals via p115RhoGEF Cascades Regulating JNK1 and Primitive Endoderm Formation. J. Biol. Chem. 279: 54896-54904
Yin, D., Gavi, S., Wang, HY., and Malbon C.C. (2004)
      Probing receptor  structure/function with chimeric G-protein-coupled receptors.  Mol. Pharmacol. 65:1323-32

Wang, HY. (2004)
      Wnt-frizzled signaling via cyclic GMP. Front Biosci. 9:1043-7.
Li, H., Malbon, C.C., and Wang, HY. (2004)
      Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells. Mol. Pharmacol. 65:45-55
Malbon, C.C., Tao, J. and Wang, HY. (2004)
       AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes.
Biochem. J. 379:1-9.Shumay, E., Gavi, S.,Wang, HY., and Malbon, C.C. (2004)
      Trafficking of b2-adrenergic   receptors: insulin and b-agonists regulate internalization by distinct cytoskeletal pathways.  J. Cell Sci. 117:593-600
Wang, HY. and Malbon, C.C. (2004)
      Wnt-frizzled signaling to G-protein-coupled  effectors. Cell Mol. Life Sci. 61:69-75.
Tao, J., Wang, HY., and Malbon, C.C. (2003)
      Protein kinase A regulates AKAP250 (gravin) scaffold binding to the b2-adrenergic receptor. EMBO J. 22:6419-29.
Wang, HY. And Malbon, C.C. (2003)
Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions. Science 300:1529-30.
Wang, HY., Chzng, Z. and Malbon, C.C. (2003)
       Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Cancer Lett. 191:229-37.
Ahumada, A., Slusarski, D.C., Liu, X., Moon, R.T., Malbon, C.C. and Wang, HY. (2002)
      Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science. 298:2006-10
Shumay, E., Song, X., Wang, HY. and Malbon, C.C. (2002)
      pp60Src mediates insulin-stimulated sequestration of the b2-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation. Mol. Biol. Cell 13:3943-54
Huang, XP., Song, X., Wang, HY. And Malbon, C.C. (2002)
      Targeted expression of activated Q227
L Gas in vivo. Am. J. Physio.l Cell Physiol. 283:C386-95.Liu, T., Lee, YN., Malbon, C.C. and Wang, HY. (2002)
      Activation of the b-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid. J Biol. Chem. 277:30887-91.
DeCostanzo, A.J., Huang, XP., Wang, HY. And Malbon, C.C. (2002)
      The Frizzled-1/b2-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor. Naunyn Schmiedebergs Arch Pharmacol. 365:341-8.
Doronin, S., Shumay, E., Wang, HY. And Malbon, C.C. (2002)
      Akt mediates sequestration of the b2-adrenergic receptor in response to insulin. J. Biol. Chem. 277:15124-31.
Doronin, S., Wang, HY. And Malbon, C.C. (2002)
      Insulin stimulates phosphorylation of the b2-adrenergic receptor by the insulin receptor, creating a potent feedback inhibitor of its tyrosine kinase. J. Biol. Chem. 277:10698-703.
Huang, XP., Rosenquest, T.A., Wang, HY. And Malbon, C.C. (2002)
      Inducible, tissue-specific suppression of heterotrimeric G protein alpha subunits in vivo. Methods Enzymol. 344:318-27.
Song, X., Tao, J., Huang, XP., Rosenquest, T.A., Malbon, C.C. and Wang, HY. (2002)
      Targeted, regulatable expression of activated heterotrimeric G protein alpha subunits in transgenic mice. Methods Enzymol. 344:309-18.
Wang, HY., Kanungo, J. and Malbon, C.C. (2002)
      Expression of Ga13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4.  J. Biol. Chem. 277:3530-6.
Doronin,S., Shumay, E., Wang, HY. and Malbon, C.C. (2002)
      Lithium suppresses signaling and induces rapid sequestration of b2-adrenergic receptors. Biochem. Biophys. Res. Commun. 288:151-5.
Malbon, C.C., Wang, HY., and Moon, R.T. (2001)
      Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?  Biochem. Biophys. Res. Commun. 287:589-93.
Tao, J., Malbon, C.C. and Wang, HY. (2001)
      Gai2 enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. J. Biol. Chem. 276:39705-12.
Song, X., Zheng, X., Malbon, C.C. and Wang, HY. (2001)
      Gai2 enhances in vivo activation of and insulin signaling to GLUT4. J. Biol. Chem. 276:34651-8.
Tao, J., Malbon, C.C. and Wang, HY. (2001)
      Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo. J. Biol. Chem. 276:29520-5.
Liu, T., DeCostanzo, A.J., Liu, X., Wang, HY., Hallagan, S., Moon, R.T. and Malbon, C.C. (2001)
      G protein signaling from activated rat frizzled-1 to the b-catenin-Lef-Tcf pathway. Science 292:1718-22.