Sherif R. Abdel-Misih, MD — Academic Profile

I am an Associate Professor of Surgery with a clinical focus on complex management of patients with gastrointestinal cancers. I aim to pursue more effective as well as less invasive surgical treatments when appropriate through innovation and research in order to achieve the goals of cancer disease control and potential cure. Additionally, I have focused on surgical education with goals to enhance and improve the surgical education of our future surgeons and physicians. 

• Department of Surgery Faculty Teacher of the Year Award (Bestowed by the Residents and Fellows in Surgery). The Ohio State University Wexner Medical Center. 2018 – 2019 
• Castle Connolly, Top Doctor – Surgery (Columbus, OH) – 2017, 2018, 2019. 
• Columbus Monthly Magazine Top Doctor – Surgery (Columbus, OH) – 2017, 2018. 
• Top Patient Satisfaction (Top 10% of National Providers): 2013 – 2014, 2015 – 2016, 2016 – 2017, and 2017 - 2018
• Department of Surgery Michael J. Walker, M.D. Faculty Teaching Award (Bestowed by the Medical Students). The Ohio State University Wexner Medical Center & College of Medicine. June 14, 2014
• Department of Surgery Fellow Teaching Award (Bestowed by the Residents in Surgery). The Ohio State University Medical Center & College of Medicine. June 12, 2010
• Department of Surgery Fellow Teaching Award ((Bestowed by the Residents in Surgery). The Ohio State University Medical Center & College of Medicine. June 12, 2009 

• Past and current research endeavors directed at clinical/translational research related to gastrointestinal malignancies as well as didactic and skills based scientific inquiry into surgical education and training. The following list includes IRB approved research and clinical trials participated in while at The Ohio State University Wexner Medical Center and Arthur G. James Cancer Hospital. 
• A Multicenter Study with an Open-Label Phase Ib Part Followed by a Randomized, Placebo-Controlled, Double-Blind, Phase II Part to Evaluate Efficacy, Safety, Tolerability, and Pharmacokinetics of the DNA-PK Inhibitor M3814 in Combination with Capecitabine and Radiotherapy in Participants with Locally Advanced Rectal Cancer. Role: Co-Investigator
• Coe J, Abdel-Misih S, Marten E, Hitchcock C, Allen H, O’Neill M, NIH Academic-Industrial R01 Proposal: Fast Infrared Cancer Probe for Metastatic Liver Cancer – Submitted. Co-investigator
• A Single-Arm, Multi-Center, Open-Label Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Melphalan/HDS Treatment in Patients with Hepatic-Dominant Ocular Melanoma. Role: Site Principal Investigator
• A Randomized Controlled Study to Compare the Efficacy, Safety and Pharmacokinetics of Melphalan/HDS Treatment Given Sequentially Following Cisplatin/Gemcitabine versus Cisplatin/Gemcitabine in Patient with Intrahepatic Cholangiocarcinoma. Role: Site Principal Investigator
• Colon Enhanced Recovery After Surgery: The Ohio State University Wexner Medical Center Experience. Role: Principal Investigator
• Preoperative Evaluation, Clinicopathologic Factors, Management Strategies, and Outcomes of Colon and Rectal Cancer: A Multi-Institutional Experience –Role: Site Principal Investigator 
• Phase IIb, Nonrandomized, Open-Label Trial with Mouse Renal Adenocarcinoma (RENCA) Cell Containing Agarose-Agarose Macrobeads Compared with Best Supportive Care in Patients with Treatment-Resistant, Metastatic Colorectal Carcinoma. Sponsor: Rogosin Institute. Role: Site Principal Investigator
• Implementation of a Resident-Designed General Surgical Didactic Curriculum: Implications on Academic Performance and Resident Satisfaction. Role: Principal Investigator
• Assessing Training Disparities in General Surgical Residency: Is there a Difference in Operative Case Volume in Minorities? Role: Principal Investigator
• Retrospective Study of the Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Role: Principal Investigator
• Enhanced Recovery after Surgery in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Role: Principal Investigator
• Multi-institutional HIPEC collaborative. Role: Co-Investigator
• Retrospective Evaluation of Patients Undergoing Pelvic Exenteration. Role: Principal Investigator
• Neoadjuvant GMCI plus modified FOLFIRINOX and chemoradiation for advanced non-metastatic pancreatic adenocarcinoma. Role: Co-Investigator
• A Randomized Prospective Multicenter Trial of Pancreas Resection with and without Routine Intraperitoneal Drainage. Role: Co-Investigator
• A Phase I trial of MEK Inhibitor GSK1120212 (Trametinib) in Combination with Neoadjuvant 5-Fluorouracil Chemoradiation in the Treatment of Rectal Cancers. Role: Co-Investigator
• A Phase III Multicenter Randomized Trial of Sentinel Lymphadenectomy and Complete Lymph Node Dissection Versus Sentinel Lymphadenectomy Alone in Cutaneous Melanoma Patients with Molecular or Histopathological Evidence of Metastases in the Sentinel Node. Role: Co-Investigator
• A Banking Facility for Biological Samples and Clinical Data to Study Neuroendocrine Tumors. Role: Co-Investigator
• ECOG-E1208: A Phase III Randomized, Double-Blind Trial of Chemoembolization With or Without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients With and Without Vascular Invasion. Closed to accrual 11/18/2013. Role: Co-Investigator
• TS-102: A Phase III Clinical Trial Evaluating TheraSphere^® in Patients with Metastatic Colorectal Carcinoma of the Liver who have Failed First Line Chemotherapy. Role: Sub-Investigator
• Retrospective MRI Evaluation of Diffuse Abdominal Metastatic Disease: Value in Pre-Operative Assessment of the Peritoneal Carcinomatosis Index (PCI). Role: Co-Investigator
• RTOG 1102 – A Phase I Study of Induction Ganitumab (IND #113278) and Gemcitabine, Followed by Ganitumab, Capecitabine, and 3D-Conformal Radiation Therapy (3D-CRT) with Subsequent Maintenance Therapy for Locally Advanced Pancreatic Cancer. Role: Co-Investigator
• A Phase 1/2a Dose-escalation Study of JX-594 (Thymidine Kinase-Deactivated Vaccinia Virus plus GM-CSF) Administered by Multiple Intravenous (IV) Infusions Followed by Intratumoral (IT) Boosts Alone and in Combination with Irinotecan. Role: Co-Investigator
• Pilot Study Evaluating a Combined and Integrated Technological Approach of 18F-FDG-Directed Perioperative PET/CT Imaging and Intraoperative Handheld Gamma Probe Detection of Known and occult Disease in Patients Undergoing Surgery for Solid Malignances. Closed accrual 7/2011. Role: Co-Investigator
• Electromagnetic detection and imaging of liver metastases from colorectal cancer. Role: Co-Investigator 

• > Click here to see abstracts/full text of Dr. Abdel-Misih's journal articles on PubMed (National Library of Medicine).

• Kimbrough C, Beal E, Abdel-Misih S, Pawlik T, Cloyd J. Survival Outcomes Among Patients with Gastric Adenocarcinoma who Received Hyperthermic Intraperitoneal Chemotherapy with Cytoreductive Surgery. JAMA Surgery. 2019 Jun 12. PMID: 31188418
• Paredes A, Guzman Pruneda F, Abdel-Misih S, Hays J, Dillhoff M, Pawlik T, Cloyd J. Perioperative Morbidity of Gastrectomy during CRS-HIPEC: An ACS-NSQUIP Analysis. Journal of Surgical Research. 2019 Apr 17; 241:31-39. PMID: 31004870 
• Lyell N, Kitano M, Smith B, Gleisner A, Backes F, Cheng G, McCarter M, Abdel-Misih S,  Jones E. The Effect of Preoperative Nutritional Status on Postoperative Complications and Overall Survival in Patients Undergoing Pelvic Exenteration: A Multi-disciplinary, Multi-Institutional Cohort Study. Am J Surg. 2019 Apr 4. PMID: 30982571
• Woelfel I, Strosberg D, Abdel-Misih S, Harzman A. Growth in Monthly Case Volume in the First Year of Post-Graduate Surgical Training. Am Surg. 2019 Jan 1; 85(1). PMID: 30764914
• Xourafas D, Pawlik T, Ejaz A, Dillhoff M, Abdel-Misih S, Tsung A, Cloyd J. Impact of Concomitant Ablation on the Perioperative Outcomes of Patients with Colorectal Liver Metastases Undergoing Hepatectomy: A Propensity Score Matched Nationwide Analysis. HPB. 2019 Feb 2. [Epub ahead of print]. PMID: 30718184
• Paredes A, Abdel-Misih S, Schmidt C, Dillhoff M, Pawlik T, Cloyd J. Predictors of Readmission after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Journal of Surgical Research. 2019 Feb; 234: 103 – 109. PMID: 30527460 
• Chakedis J, Beal E, Sun S, Galo J, Chafitz A, Dillhoff M, Reardon J, Dillhoff M, Pawlik T, Abdel-Misih S, Bloomston M, Schmidt C. Implementation and Early Outcomes for a Surgeon-Directed Hepatic Arterial Infusion Pump Program for Colorectal Liver Metastases. Journal of Surgical Oncology. 2018 Dec; 118 (7): 1065 – 1073. PMID: 30376157
• Abdel-Misih S, Musindi W, Strafford K, Walker C, Verbeck-Osterhour N, Tartaglia K, Harman A. Early Experience with an Integrated Surgical and Obstetrics/Gynecology Clerkship: We Do Get Along. Am Journal of Surgery. 2018 Nov; 216(5):1016-1021. PMID: 29471965
• Burkhart J, Owen D, Shah MH, Abdel-Misih S, Roychowdhury S, Wesolowski R, Haraldsdottir S, Reeser JW, Samorodnitsky E. Smith A, Konda B. Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon. Journal of the National Comprehensive Cancer Network. 2018 Sep; 16(9): 1035-1040. PMID: 30181415
• Hughes TM, Palmer EN, Capers Q, Abdel-Misih S, Harzman A, Beal E, Woelfel I, Noria S, Agnese D, Dillhoff M, Grignol V, Howard JH, Shirley LA, Terando A, Schmidt C, Cloyd J, Pawlik T. Practices and Perceptions Among Surgical Oncologists in the Perioperative Care of Obese Cancer Patients. Ann Surg Oncol. 2018 Sep; 16 (9): 1035 – 1040. PMID: 29987611
• Beal E, Tumin D, Chakedis J, Porter E, Moris D, Zhang X, Abdel-Misih S, Dillhoff M, Manilchuk A, Cloyd J, Schmidt C, Pawlik T. Identification of Patients at High Risk for Post-Discharge Venous Thromboembolism after Hepato-Pancreatico-Biliary Surgery: Which Patients Benefit from Extended Thromboprophylaxis? HPB 2018 Jul; 20 (7):621-630. PMID: 29472105
• Cloyd J, Abdel-Misih S, Hays J, Dillhoff M, Pawlik T, Schmidt C. Impact of Synchronous Liver Resection on the Perioperative Outcomes of Patients Undergoing CRS-HIPEC. Journal of Gastrointestinal Surgery. 2018 Apr 30. PMID: 29713875
• Strosberg D, Quinn K, Abdel-Misih S, Harzman A. Redefining the Surgical Council of Resident Education (SCORE) Curriculum: A Comparison to the Operative Experiences of Graduated General Surgical Residents. American Surgeon. 2018 Apr 1;84(4):526-530. PMID:29712600
• Brathwaite SA, Smith S, Frankel W, Hays J, Yearsley MM, Abdel-Misih S. Mixed Adenoneuroendocrine Carcinoma: A Review of Pathologic Characteristics. Human Pathology. 2018 Mar; 73: 184-191. PMID: 29288693
• Nguyen P, Wuthrick E, Chablani P, Robinson A, Simmons L, Wu C, Arnold M, Harzman AE, Husain S, Schmidt C, Abdel-Misih S, Bekaii-Saab T, Chakravarti A, Williams TM. Does Delaying Surgical Resection after Neoadjuvant Chemoradiation Impact Clinical Outcomes in Locally Advanced Rectal Adenocarcinomas? A Single-Institution Experience. Am J Clin Oncol. 2018 Feb; 41(2):140-146. PMID: 26535992
• Ahn DH, Wu C, Wei L, Williams TM, Wuthrick E, Abdel-Misih S, Harzman A, Husain S, Schmidt C, Goldberg RM, Bekaii-Saab T. The Efficacy of Adjuvant Chemotherapy in Patients with Stage II/III Resected Rectal Cancer Treated with Neoadjuvant Chemoradiation Therapy. Am J Clin Onocol. 2017 Dec;40(6):531-534. PMID: 25723741
• Smith B, Jones EL, Kitano M, Gleisner A, Lyell N, Cheng G, McCarter M, Abdel-Misih S, Backes F. Influence of Tumor Size on Outcomes Following Pelvic Exenteration. Gynecology Oncology. 2017 Nov; 147(2):345-350. PMID: 28822555
• Dwight Owen, Andrew Alexander, Bhavana Konda, Lai Wei, Jessica Hemminger, Carl R Schmidt, Sherif Abdel-Misih, Mary Dillhoff, Jennifer Sipos, Lawrence Kirschner. Combination Therapy with Capecitabine and Temozolomide in Patients with Low and High Grade Neuroendocrine Tumors, with an Exploratory Analysis of O⁶-Methylguanine DNA Methyltransferase as a Biomarker for Response. Oncotarget. 2017 Oct 24;8(61):104046 – 104056. PMID: 29262620
• Abdel-Misih S, Bekaii-Saab T. Confusion Solved; Sort Of. Journal of National Comprehensive Cancer Network(JNCCN). 2017 Aug; 15:975-976
• Abdel-Misih S, Wei L, Benson III A et al. Neoadjuvant Therapy for Rectal Cancer Affects Lymph Node Yield and Status Without Clear Implications on Outcome: The Case for Eliminating a Metric and Utilizing Preoperative Staging to Guide Therapy. Journal of National Comprehensive Cancer Network (JNCCN). 2016 Dec; 14(12):1528-1534. PMID: 27956537
• Wuthrick EJ, Williams TM, Wei L, Umar H, Savysan A, Mikhail S, Ciombor K, Noonan A, Roychowdhury S, El-Dika S, Krishna S, Upchurch B, Arnold M, Harzman A, Abdel-MisihS, Cirocco W, Bekaii-Saab T, Wu C. Phase 1 Study of Trametinib and Neoadjuvant Chemoradiation (CRT) in Locally Advanced Rectal Cancer (LARC) with KRAS, BRAF, or NRAS Mutations. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96 (2S):S107-108. PMID:27675540
• Strosberg D, Quinn K, Abdel-Misih S, Harzman A. An Analysis of Operative Experiences of Junior General Surgical Residents and Correlation with the SCORE Curriculum. Journal of Surgical Education. 2016 Aug 8. PMID: 27515032
• Brathwaite S, Yearsley M, Bekaii-Saab T, Wei L, Frankel W, Wu C, Abdel-Misih S. Mixed Adeno-Neuroendocrine Carcinoma (MANEC): An Aggressive Clinical Entity. Ann Surg Oncol. 2016 Jul;23(7):2281-6. PMID: 26965701
• Hornor M, Abdel-Misih S. Surgical Treatment for Hypoglycemia: A Case Report. Arch Surg Oncol. 2016 July 20. 2:115. doi:10.4172/2471-2671.1000115
• Brathwaite S, Yearsley M, Bekaii-Saab T, Wei L, Schmidt C, Dillhoff M, Frankel W, Hays J, Wu C, Abdel-Misih S. Appendiceal Mixed Adeno-Neuroendocrine Carcinoma (MANEC): A Population-Based Study of the Surveillance, Epidemiology, and End Results (SEER) Registry. Frontiers of Oncology. 13 June 2016; 6:148. PMID: 27379210 
• Shaib WL, Martin LK, Choi M, Chen Z, Krishna K, Kim S, Brutcher E, Staley C 3rd, Maithel SK, Philip P, Abdel-MisihS, Bekaii-Saab TS, El-Rayes BF..Hyperthermic Intraperitoneal Chemotherapy Following Cytoreductive Surgery Improves Outcome in Patients With Primary Appendiceal Mucinous Adenocarcinoma: A Pooled Analysis From Three Tertiary Care Centers.Oncologist. 2015 Aug; 20(8): 907-14. PMID: 26070916
• Ahn DH, Wu C, Wei L, Williams TM, Wuthrick E, Abdel-MisihS, Harzman A, Husain S, Schmidt C, Goldberg RM, Bekaii-Saab T. The Efficacy of Adjuvant Chemotherapy in Patients With Stage II/III Resected Rectal Cancer Treated With Neoadjuvant Chemoradiation Therapy. Am J Clin Oncol.  2015 Feb 25. PMID: 25723741
• Prakash S, Karnes MP, Sequin EK, West JD, Hitchcock CL, Nichols SD, Bloomston M, Abdel-Misih SR, Schmidt CR, Martin EW jr, Povoski S, Subramaniam VV. Ex Vivo Electrical Impedance Measurements on Excised Hepatic Tissue from Human Patients with Metastatic Colorectal Cancer. Physiol Meas. 2015 Feb; 36(2):315-28. PMID: 25597963
• Nichols SD, Albert S, Shirley L, Schmidt C, Abdel-Misih S, El-Dika , Groce JR, Wu C, Goldberg RM, Bekaii-Saab T, Bloomston M. Outcomes in Patients with Obstructive Jaundice from Metastatic Colorectal Cancer and Implications for Management. J Gastrointest Surg. 2014 Dec; 18(12):2186-91. PMID: 25300799
• Van Buren G 2nd, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WE. A Randomized Prospective Multicenter Trial of Pancreaticoduodenectomy with and without Routine Intraperitoneal Drainage. Ann Surg. Apr 2014. 259(4):605-612. PMID: 24374513 (Cited 232 times as of 7/10/19) 
• Henry JC, Pouly S, Sullivan R, Sharif S, Klemanski D, Abdel-Misih S, Arradaza N, Jarjoura D, Schmidt C, Bloomston M. A Scoring System for the Prognosis and Treatment of Malignant Bowel Obstruction. Surgery. Oct 2012. 152(4): 747-57. PMID: 22929404
• Rose JS, Serna DS, Martin LK, Li X, Weatherby LM, Abdel-Misih S, Zhao W, Bekaii-Saab T.   Influence of KRAS Mutation Status in Metachronous and Synchronous Metastatic Colorectal Adenocarcinoma. Cancer. Jun 6 2012 [Epub]. PMID: 22674181
• NB Jones, ME McNally, L Malhotra, S Abdel-Misih, EW Martin, M Bloomston, CR Schmidt. Repeat Hepatectomy for Colorectal Cancer is Safe but Marginally Effective. Annals of Surgical Oncology. July 2012; 19(7):2224-9. PMID: 22207046
• S Abdel-Misih, I Hatzaras, P Muscarella, S Melvin, E Ellison, S Schmidt, M Bloomston.  Failure of Normalization of CA19-9 Following Resection for Pancreatic Cancer is Tantamount to Metastatic Disease. Annals of Surgical Oncology. April 2011. 18(4); 1116-1121. PMID: 21042945 (Cited 26 times as of 7/10/19)
• S Abdel-Misih. A Scientific Look at Isolated Limb Perfusion: The Mechanisms and Pathologic Effects of Regional Perfusion in Extremity Soft Tissue Sarcoma. Journal of Surgical Oncology. April 2011. 103(5), 369-370. PMID: 21400517
• S Abdel-Misih, J Broome, X Li, D Arrese, EP Chambers, J Kenneth Jacobs, JE Phay.  Changing Intraoperative Parathyroid Hormone Collection Sites from Peripheral to Central Does Not Affect Predictive Accuracy During Parathyroidectomy. Annals of Surgical Oncology. March 2011. 18(3); 771-776. PMID: 20949324
• S Abdel-Misih, M Bloomston. Liver Anatomy. Surgical Clinics of North America. August 2010. 90(4); 643-53. PMID: 20637938 (cited 154 as of 7/10/19)
• D Murrey, E Bahnson, N Hall, S Povoski, C Mojzisik, D Young, S Sharif, M Johnson, S Abdel-Misih, E Martin jr., M Knopp. Perioperative 18F-FDG Imaging Using the Becquerel as a Quantitative Measure for Optimizing Surgical Resection in Patients with Advanced Malignancy. The American Journal of Surgery 12/2009; 198(6), 834-840. PMID: 19969138
• R Chokshi, S Abdel-Misih, M Bloomston. Surgical Management of Colorectal Cancer: A Review of the Literature. Indian Journal of Surgery. 12/1/2009, 71(6), 350-355. PMID: 23133190
• S Abdel-Misih, C Schmidt, M Bloomston. Update & Review of the Multidisciplinary Management of Stage IV Colorectal Cancer with Liver Metastases; World Journal of Surgical Oncology. September 2009, 7:72. PMID: 19788748
• Schaner P, Rosato FE Jr, Tarola NA, Eisenberg J, Abdel-Misih S, Tamburrino J, Popowich DA, Torino PJ, DiMuzio P. Acellular Scaffolding for Vascular Tissue Engineering in a Canine Model. J Surg Res. 2003:114:297. 







 
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• Fellow, American College of Surgeons (FACS)
• Memberships
• American Hepato-Pancreato-Biliary Association
• American College of Surgeons
• American College of Surgeons, Ohio Chapter
• Association for Academic Surgery
• American Society of Peritoneal Surface Malignancies
• Society of American Gastrointestinal and Endoscopic Surgeons
• Columbus Surgical Society
• Society for Surgery of the Alimentary Tract
• Society of Surgical Oncology
• Zollinger urgical Society
• Editorial Board
• World Journal of Surgical Oncology
• Reviewer
• Journal of Gastrointestinal Surgery