Yu Sun, M.D., Ph.D.

Yu Sun, Ph.D. 
Research Assistant Professor 
e-mail: Yu.Sun@stonybrookmedicine.edu 

Dr. Sun received her Ph.D. in 2006 from the National University of Singapore and the Karolinska Institute in Sweden. For her thesis, Dr. Sun worked on the chemotherapeutic resistance in B lymphoma cells, focusing on the apoptotic signaling pathway.  Dr. Sun is currently working on the role of reactive oxygen and nitrogen species (RONS) in cancer control with emphasis on the thioredoxin system.  She is also studying in depth a novel anitcancer peptide, of which she is a co-inventor.

Selected publications

1. Rigas B, Sun Y. Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer. Br J Cancer, 2008 Apr 8; 98(7):1157-60.
2. Sun Y. Rigas B. The thioredoxin system mediates redox-induced cell death in human colon cancer cells: Implications for the mechanism of action of anticancer agents. Cancer Res, 2008; 68:8269-77
3. Zhou H, Huang L, Sun Y, Rigas B. Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling. Cancer Lett, 2009 Jan 18; 273(2): 292-9. Epub 2008 Sep. 20
4. Sun Y, Chen J. Rigas B. Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. Carcinogenesis, 2009 Jan;30(1);93-100. Epub 2008 Oct 24
5. Sun Y, Ottosson A, Pervaiz S, Fadeel B. Smac-mediated potentiation of apoptosis of B lymphoma cells requires cytosolic Apaf-1 expression. Leukaemia, 2007 May; 21(5):1035-43
6. Sun Y, Orrenius S, Pervaiz, S, Fadeel B. Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B lymphoma cells: a novel mechanism of chemoresistance. Blood, 2005, 105: 4070