Anne Felicia Ambrose, MBBS/MD

Department of Neurology 

Email: Anne.Ambrose@stonybrookmedicine.edu

Location: T12-02 Health Sciences Center, Stony Brook, NY 11794-8121

Area of Research

Dr. Ambrose research interests focuses on the impact of traumatic brain injury on neurodegenerative disorders. She is also interested in the role of exercise in management of cognitive impairments

Education and Training

Education:

St John’s Medical School, Bangalore, India

Kerala-Einstein Aging Study, Nat Institute of Aging, NIH R01 AG 6/1/19-5/31/25
    
Biological underpinnings of Motoric Cognitive Risk Syndrome: multi-center study, National Institute of Aging 1R01AG057548-01A1 06/15/2020 – 03/31/2025
               
Cognitive decline and dementia in older Kerala Americans: Akkare Study
National Institute of Aging 1R01AG084567-01 May 2024-April 2029

Cognitive intervention to improve simple and complex walking National Institute of Aging. 
NIH 1 R01 AG050448-01 9/15/2015-4/30/2020

Home Based COVID-19 Rehabilitation Program: A pilot clinical trial, National Center for Advancing Translational Sciences Title: Clinical and Translational Science Award 5UL1TR002556-04 - New Banner Fund/Index# 31183 8/17/2020- 2/28/2021

Cognitive intervention to improve simple and complex walking, National Institute of Aging. 
NIH 1 R01 AG050448-01 9/15/2015-4/30/2020

Social Dancing Intervention for older adults at high risk of Alzheimer’s disease and other dementia’s: A pilot study, National Institute of Aging. NIH 1R21AG057586, 9/15/2018-8/31/2020
Effects of Modafinil on Post TBI Fatigue H133A020501, NIDRR,4/1/2004-9/30/2007 

Effects of Aerobic Exercise on Cognition, mood, and Fatigue Following Traumatic  Brain Injury. Relationship Between Post TBI Fatigue and Sleep Architecture. Center for Disease Control and NIDRR. H133A070033, 10/1/2007 – 9/30/2012

Kerala-Einstein study: Risk factors for cognitive decline NIH: Fogarty International Center, R21 AGO29799, 7/1/2008-6/30/2010

Kerala-Einstein study: Healthy lifestyle, vascular disease, and cognitive decline.  NIA. 1 R01 AG039330-01. 04/01/2011 to 03/30/2016

Phase III Multi-center, double blind prospective randomized placebo-controlled study assessing the efficacy and safety of dysport used for the treatment of upper and lower limb spasticity in adult subjects with hemiparesis due to stroke or traumatic brain injury. Ipsen Pharmaceuticals. Y-55-52120-140. 01/1/11-10/31/13

Prospective, open label non-randomized, single-arm, multi-center, dose titration study to investigate the safety and efficacy of NT201 in subjects deemed to require total body doses of 800 U of NT201 during the course of the study for the treatment of upper and lower limb spasticity of the same body side due to cerebral causes 15328 CRM:01110388. Merz Pharmaceuticals. 05/31/12 – 05/30/13

Effects of light exposure on sleep during acute rehabilitation after TBI. NIDRR/DOD.  Project ID: IF1530304. 08/1/12-07/31/17. 

Verghese J, Lipton RB, Katz MJ, Hall CB, Derby C, Ambrose AF, Kuslansky G, Sliwinski M, qBuschke H. “Leisure activities and the risk of dementia in the elderly”. N Engl J Med2003; 348: 2508-2516

Ambrose AF, LeValley A, Verghese J.”A Comparison of Parkinsonian and Frontal gaits in the Elderly”. J Neurol Sci, 2006 Oct 25; 248(1-2):215-8. Epub 2006 Jun 9

Verghese J, LeValley A, Hall CB, Katz MJ, Ambrose AF, Lipton RB. “Epidemiology of Gait Disorders in Community Residing Older Adults”. J Am Geriatr Soc 2006, 54: 255-261

Ashman TA, Cantor JB, Gordon WA, Spielman L, Flanagan S, Ginsberg A, Engmann C, Egan M, Ambrose F, Greenwald B. “A randomized controlled trial of sertraline for the treatment of depression in persons with traumatic brain injury”. Arch Phys Med Rehab. 2009 May; 90(5): 733-40

Verghese J, Ambrose AF, Lipton RB, Wang C. “Neurological gait abnormalities and risk of falls in older adults”. J Neurol. 2009 Sep 26. PMID:19784714

Ambrose AF, Verghese J, “Gait Evaluation to assess fall risk:  a neurological perspective”, Annales de Gerontologie, December 2009; 2(4): 219-21

Ambrose AF, Noone ML, Pradeep VG, Johnson B, Salam KA, Verghese J. “Gait and Cognition in Older Adults: insights from the Bronx and Kerala”. Ann Indian Acad Neurol, Dementia Supplement 2010 Dec:13(Suppl 2):S99-S103. doi: 10.4103/0972-2327.74253.

Verghese J, Mahoney J, Ambrose AF; Wang C, Holtzer R. “Effect of Cognitive Remediation on Gait in Sedentary Seniors”. J Gerontol Series A: Biological Sciences and Medical Sciences 2010; doi: 10.1093/gerona/glq127

Verghese J, Noone ML, Johnson B, Ambrose AF, Wang C, Buschke H, Pradeep VG, Abdul Salam K, Shaji KS, Mathuranath PS. “Picture-based memory impairment screen for dementia”. J Am Geriatr Soc. 2012 Nov; 60(11): 2116-20. Doi:10.1111/j.1532-5415.2012.04191.x.Epub 2012 Oct 5

Verghese J, Noone ML, Johnson B, Ambrose AF, Wang C, Buschke H, Pradeep VG, Abdul Salam K, Shaji KS, Mathuranath PS “Picture-based memory impairment screen for dementia” .J Am Geriatr Soc. 2012 Nov;60(11):2116-20. doi: 10.1111/j.1532-5415.2012.04191.x. Epub 2012 Oct 5.

Ambrose AF, Paul G, Hausdorff J. “Risk factors for falls among older adults: A review of the literature”. Maturitas. (Official Journal of the European Menopause and Andropause Society) 2013 Mar 21. doi:pii: S0378-5122(13)00054-6. 10.1016/j.maturitas.2013.02.009.

Hirschson CI, Gordon WA, Singh A, Ambrose A, Spielman L, Dams O’Connor K, Cantor J,  Dijkers M. “Mortality of elderly individuals with TBI in the first 5 years following injury”; NeuroRehabilitation. 2013;32(2):225-32. doi: 10.3233/NRE-130840. 

Lu W, Cantor J, Aurora RN, Nguyen M, Ashman T, Spielman L, Ambrose A, Krellman JW, Gordon W.“Variability of respiration and sleep during polysomnography in individuals with TBI.” NeuroRehabilitation 2014 Jan 1;35(2):245-51. doi: 10.3233/NRE-141117.PMID:24990025

Lu W, Cantor JB, Aurora RN, Gordon WA, Krellman JW, Nguyen M, Ashman TA, Spielman L, Ambrose AF “The relationship between self-reported sleep disturbance and polysomnography in individuals with traumatic brain injury”. Brain Inj 2015;29(11):1342-50. doi: 10.3109/02699052.2015.1043947. Epub 2015 Jul 23.

Anne Ambrose, Lisanne Cruz, Geet Paul “Falls and Fractures: A systematic approach to screening and prevention”, Maturitas. (Official Journal of the European Menopause and Andropause Society). 2015,September 2015 Volume 82, Issue 1, Pages 85–93

Verghese J, Ayers E, Mahoney J, Ambrose A, Wang C, Holtzer R “Cognitive remediation to enhance mobility in older adults: The CREM Study” Neurodegener Dis Manag 2016 Dec;6(6):457-466. Epub 2016 Nov 4.

Raman Sharma MD, Marie Spencer PhD RN CRRN, Barry Jordan MD MPH, Karen M. Pechman MD, Anne F. Ambrose MD.” Improving Fall Rates Below the National Average in an Acute Rehabilitation Hospital Using Modified Screening Tools: A retrospective analysis.”  PM&R Journal of AAPM&R. September 2017 Volume 9, Issue 9, Supplement 1, Pages S181–S182 (DOI: http://dx.doi.org/10.1016/j.pmrj.2017.08.095 )

Ambrose Anne Felicia, Bartels Matthew Norbert, Verghese Tanya Cecilia, Verghese Joe. “Patient and caregiver guide to managing COVID-19 patients at home” Journal of the International Society of Physical and Rehabilitation Medicine (epub ahead of print: April 15, 2020)

Blumen HM, Ayers E, Wang C, Ambrose AF, Verghese J. “A social dancing pilot intervention for older adults at high risk for Alzheimer's disease and related dementias”. Neurodegener Dis Manag. 2020;10(4):183-194. PubMed PMID: 32741240; PubMed Central PMCID: PMCPMC7426754.

Savitzky J, Rothfus T, Wong S, Ambrose AF Tuck and Turn: A Protocol for Prone Positioning of Critically Ill Patients with COVID-19 on Mechanical Ventilation. Arch Phys Med Rehabil. 2020;101(12):e153. doi:10.1016/j.apmr.2020.10.084

Ambrose AF, Gulley E, Verghese T, Verghese J. “Home-based exercise program for older adults with Motoric Cognitive Risk syndrome: feasibility study” Neurodegenerative Disease Management.  J.Neurodegener Dis Manag. 2021 May 20. doi: 10.2217/nmt-2020-0064. Online ahead of print. PMID: 34011161

Joe Verghese, Janet Mahoney, Emmeline Ayers, Anne Ambrose, Cuiling Wang, Roee Holtzer “Computerized cognitive remediation to enhance mobility in sedentary older adults: randomized  controlled trial” The Lancet Healthy Longevity Vol 2, Issue 9, September 2021, Pages e571-e579, https://doi.org/10.1016/ S2666-7568(21)00173-2  https://doi.org/10.1016/S2666-7568(21)00173-2

Shreya Dunddumalla  Surendra Barshikar , William N. Niehaus, Anne F. Ambrose, Soo Y Kim , Benjamin A. Abramoff “A Survey of Dedicated PASC Clinics: Characteristics, Barriers and Spirit of Collaboration” PM R. 2022 Jan 17. doi: 10.1002/pmrj.12766. Epub ahead of print. PMID: 35038230.

Anne Felicia Ambrose, MD, Anupuma Kurra, MD, Lana Tsirakidis, DPT, Kate Collins Hunt, DPT, Emmeline Ayers, MPH, Andrew Gitkind, MD, Sandeep Yerra, MD, Yungtai Lo, PhD, Nicole Ortiz, MD, Faraz Jamal, BS, Vikram Madan, MPH, Matthew N Bartels, MD, Joe Verghese, MBBS, Rehabilitation and In-Hospital Mortality in COVID-19 patients, The Journals of Gerontology: Series A, 2021;, glab321, https://doi.org/10.1093/gerona/glab321

Maltser S, Trovato E, Fusco HN, Sison CP, Ambrose AF, Herrera J, Murphy S, Kirshblum S, Bartels MN, Bagay L, Oh-Park M, Stein AB, Cuccurullo S, Nori P, Donovan J, Dams-O'Connor K, Amorapanth P, Barbuto SA, Bloom O, Escalon MX. Challenges and Lessons Learned for Acute Inpatient Rehabilitation of Persons With COVID-19: Clinical Presentation, Assessment, Needs, and Services Utilization. Am J Phys Med Rehabil. 2021 Dec 1;100(12):1115-1123. doi: 10.1097/PHM.0000000000001887. PMID: 34793372; PMCID: PMC8594401

Fine, Jeffrey, Ambrose, Anne, Didehbani, Nyaz, Fleming, Talya, Glashan, Lissette, Longo, Michele, Merlino, Alexandra, Ng, Rowena, Nora, Gerald, Rolin, Summer, Silver, Julie, Terzic, Carmen, Verduzco-Gutierrez, Monica, Sampsel, Sarah, ”Multi-Disciplinary Collaborative Consensus Guidance Statement on the Assessment and Treatment of Cognitive Impairment in Post-Acute Sequelae of SARS-CoV-2 infection (PASC) Patients” PM&R: The journal of injury, function and rehabilitation PM R. 2022 Jan;14(1):96-111. doi: 10.1002/pmrj.12745. Epub 2022 Jan 12. PMID: 34902226.

Blumen, Helena M., Ayers, Emmeline, Wang, Cuiling, Ambrose, Anne F., Jayakody, Oshadi, & Verghese. Joe. (2022). Randomized Controlled Trial of Social Ballroom Dancing and Treadmill Walking: Preliminary Findings on Executive Function and Neuroplasticity From Dementia-at-Risk Older Adults. Journal of Aging and Physical Activity. Advance online publication.  https://doi.org/10.1123/japa.2022-0176.

Jeffrey S Fine, Anne Felicia Ambrose, Nyaz Didehbani, Talya K Fleming, Lissette Glashan, Michele Longo, Alexandra Merlino, Rowena Ng, Gerald J Nora, Summer Rolin, Julie K Silver, Carmen M Terzic, Monica Verduzco-Gutierrez, Sarah Sampsel "Multi-Disciplinary collaborative consensus guidance statement on the assessment and treatment of neurologic sequelae in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)" in its current form for publication in PM&R: The journal of injury, function and rehabilitation. R 2022 Jan;14(1):96-111. doi: 10.1002/pmrj.12745. Epub 2022 Jan 12.

Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of neurologic sequelae in patients with post-acute sequelae of SARS-CoV-2 infection (PASC) Melamed E, Rydberg L, Ambrose AF, Bhavaraju-Sanka R, Fine JS, Fleming TK,  erman E, Phipps Johnson JL, Kucera JR, Longo M, Niehaus W, Oleson CV, Sampsel S, Silver JK, Smith MM, Verduzco-Gutierrez M.PM R. 2023 May;15(5):640-662. doi: 10.1002/pmrj.12976. Epub 2023 May 9. PMID: 36989078 

Sathyan S, Ayers E, Blumen H, Weiss EF, Adhikari D, Stimmel M, Abdulsalam K, Noone M, George RK, Ceide M, Ambrose AF, Wang C, Narayanan P, Sureshbabu S, Shaji KS, Sigamani A, Mathuranath PS, Pradeep VG, Verghese J. Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study. JMIR Res Protoc. 2023 Aug 17;12:e49933. doi: 10.2196/49933. PMID: 37590054.