Neil A. Nadkarni MD

Assistant Professor,
Department of Neurology 

Email: neil.nadkarni@stonybrookmedicine.edu

Location: Stony Brook University
BST 6-159E
Stony Brook NY 11794

Area of Research

Preclinical & translational stroke, neuroinflammation, innate immunity, live-animal imaging, the effect of demographics on innate immunity in stroke.

Education and Training

Education:

Postgraduate Training/Fellowships:

Cornell University

Internal Medicine
Adult Neurology Residency

R25 NINDS Research Education Program      

Neurocritical Care Fellowship                 

2018

2019

2021

NVITe, or Neurovascular Inflammation Team, is a newly established laboratory at Stony Brook University focusing on translational stroke, inflammation, physiology and behavior. We seek to understand relationships between various components of innate immunity and cerebrovascular dynamics in both preclinical and clinical stroke.

The lab, located at the Basic Sciences Tower (BST) 6-160 in a shared space under the Department of Neurology, incorporates animal surgery, live-animal imaging, advanced histopathology, flow cytometry and animal behavior metrics. We are also developing capabilities for RNA sequencing. NVITe collaborates with multiple groups at SBU, including Bioengineering, Pharmacology, Biomedical Informatics, Pathology, Physiology, Neurosurgery and the PET-CT imaging core. We are funded through the National Institutes of Health (NIH), the SBU Center for Healthy Aging, the Feldstein Medical Foundation, the American Heart Association, the Office of the Vice President for Research Seed Grant, and the Stony Brook University Research Foundation.

NVITe also works in partnership with other institutions, including Northwestern University, Washington University in St Louis, UT Houston, and University of Massachusetts. Eventually, we hope to apply our findings to improving outcomes in ischemia-reperfusion injury as well as other diseases of the central nervous system.

NIH/NINDS 5K08NS121597-03 (PI)
Defining the Spatiotemporal Underpinnings of Neutrophil Recruitment, Microvascular Flow, and Oxygenation in Ischemic Stroke

SBU Center for Healthy Aging Pilot Grant  (PI)                                               Determining how Risk Factors Modify Day 1 Stroke Inflammation and Clot to Affect 90-Day Clinical Outcome in Stroke

Feldstein Medical Foundation Translational Seed Grant  (PI)                       Determining how Risk Factors Modify Day 1 Stroke Inflammation and Clot to Affect 90-Day 

SBU Office of the Vice President for Research Spring 2024 Seed Grant  (mPI) Multi-Scale Imaging Informatics to Define Inflammatory Dynamics in Stroke Throughout Aging

American Heart Association Predoctoral Fellowship (Mentor)
Defining Key Features of Neutrophils Subject to Microglial Phagocytosis in Stroke Ischemia/Reperfusion Injury

Madeira MM, Hage Z, Kokkosis AG, Nnah K, Guzman R, Schappell LE, Koliatsis D, Resutov E, Nadkarni NA, Rahme GJ, Tsirka SE. Oligodendroglia Are Primed for Antigen Presentation in Response to Chronic Stress-Induced Microglial-Derived Inflammation. Glia. 2024 Dec 24. doi: 10.1002/glia.24661. Epub ahead of print. PMID: 39719686.

Li Y, Schappell LE, Polizu C, DiPersio J, Tsirka SE, Halterman MW, Nadkarni NA. Evolving Clinical-Translational Investigations of Cerebroprotectants in Ischemic Stroke. J Clin Med. 2023 Oct 24;12(21). doi: 10.3390/jcm12216715. Review. PubMed PMID: 37959180; PubMed Central PMCID: PMC10649331.

Nadkarni NA, Arias E, Fang R, Haynes ME, Zhang HF, Muller WA, Batra A, Sullivan DP. Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke. Am J Pathol. 2022 Nov;192(11):1619-1632. doi: 10.1016/j.ajpath.2022.07.008. Epub 2022 Aug 8. PMID: 35952762; PMCID: PMC9667712.

Nadkarni NA, Maas MB, Batra A, Kim M, Manno EM, Sorond FA, Prabhakaran S, Naidech AM, Liotta EM. Elevated Cerebrospinal Fluid Protein Is Associated with Unfavorable Functional Outcome in Spontaneous Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104605. doi: 10.1016/j.jstrokecerebrovasdis.2019.104605. Epub 2020 Jan 11. PMID: 31932209; PMCID: PMC7066873.

Complete List of Published Work available in SciENcv

https://www.ncbi.nlm.nih.gov/myncbi/1HqBfBPfSDBw_8/bibliography/public